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Mycosis Fungoides

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Atlas of Cutaneous Lymphomas

Abstract

Mycosis fungoides (MF) is a CD4+ primary cutaneous T-cell lymphoma with a good prognosis. Patients with MF classicly present with pink-to-erythematous patches, well-demarcated plaques, and/or tumors on sun-protected areas, including the flanks, breasts, inner thighs, groin, and buttocks. Cutaneous biopsies of classic MF demonstrate characteristic epidermotropism, “tagging” of atypical T cells along the dermoepidermal junction, and Pautrier microabscesses. There are a number of subtypes of MF with varied presentations, including folliculotropic MF, pagetoid reticulosis, granulomatous slack skin, poikilodermatous MF, and hypopigmented MF. This chapter will discuss the clinical presentation, prognosis, treatment, histopathology, immunohistochemistry, and molecular biology of several of the subtypes of MF. It closes with five clinical cases, each representing a different subtype of MF.

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Author information

Authors and Affiliations

  1. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA

    Amrita Goyal M.D.

  2. Drexel University College of Medicine, Philadelphia, PA, USA

    Kavita Goyal B.S.

  3. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Joi B. Carter M.D.

  4. Comprehensive Cutaneous Lymphoma Program, Massachusetts General Hospital Cancer Center, Boston, MA, USA

    Jeffrey A. Barnes M.D., Ph.D.

  5. Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Rosalynn M. Nazarian M.D.

  6. Dermatopathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Mai P. Hoang M.D. & Lyn McDivitt Duncan M.D.

  7. Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Adriano Piris M.D. & Thomas Kupper M.D.

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  1. Amrita Goyal M.D.
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  3. Joi B. Carter M.D.
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  4. Jeffrey A. Barnes M.D., Ph.D.
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  9. Lyn McDivitt Duncan M.D.
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Correspondence to Lyn McDivitt Duncan M.D. .

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Editors and Affiliations

  1. Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA

    Joi B. Carter

  2. Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA

    Amrita Goyal

  3. Dermatopathology Service, Massachusetts General Hospital, Boston, Massachusetts, USA

    Lyn McDivitt Duncan

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Goyal, A. et al. (2015). Mycosis Fungoides. In: Carter, J., Goyal, A., McDivitt Duncan, L. (eds) Atlas of Cutaneous Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-17217-0_5

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  • DOI: https://doi.org/10.1007/978-3-319-17217-0_5

  • Publisher Name: Springer, Cham

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