Skip to main content

Future Perspectives in Peyronie’s Disease

  • Chapter
Peyronie’s Disease

Abstract

This chapter provides the reader with information about future perspectives of medical treatment of Peyronie’s disease (PD).

The latest and modern therapies for PD have been listed and detailed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Korrapati N, Nanganuru HY (2014) A comprehensive review on perfusion method development for bone marrow collection and stem cell transplantation. Curr Stem Cell Res Ther 9(6):522–525

    Article  CAS  PubMed  Google Scholar 

  2. Thomas X (2014) Current indications of allogeneic stem cell transplant in adults with acute myeloid leukemia. Bull Cancer 101(9):856–865

    PubMed  Google Scholar 

  3. Scheinberg P (2012) Aplastic anemia: therapeutic updates in immunosuppression and transplantation. Hematol Am Soc Hematol Educ Program 2012:292–300

    Google Scholar 

  4. Ikehara S (2008) Stem cell transplantation for autoimmune diseases: what can we learn from experimental models? Autoimmunity 41(8):563–569

    Article  CAS  PubMed  Google Scholar 

  5. Tateishi-Yuyama E, Matsubara H, Murohara T et al (2002) Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360(9331):427–435

    Article  PubMed  Google Scholar 

  6. Talapková R, Hudecek J, Sinák I et al (2009) The salvage of ischaemic limb by therapeutical angiogenesis. Vnitr Lek 55(3):179–183 [Article in Slovak]

    PubMed  Google Scholar 

  7. Strauer BE, Brehm M, Schannwell CM (2008) The therapeutic potential of stem cells in heart disease. Cell Prolif 41(Suppl 1):126–145

    PubMed  Google Scholar 

  8. Kim SW, Houge M, Brown M et al (2014) Cultured human bone marrow-derived CD31(+) cells are effective for cardiac and vascular repair through enhanced angiogenic, adhesion, and anti-inflammatory effects. J Am Coll Cardiol 64(16):1681–1694

    Article  CAS  PubMed  Google Scholar 

  9. Goldenberg-Cohen N, Avraham-Lubin BC, Sadikov T et al (2014) Effect of coadministration of neuronal growth factors on neuroglial differentiation of bone marrow-derived stem cells in the ischemic retina. Invest Ophthalmol Vis Sci 55(1):502–512

    Article  CAS  PubMed  Google Scholar 

  10. Park TS, Bhutto I, Zimmerlin L et al (2014) Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature. Circulation 129(3):359–372

    Article  PubMed Central  PubMed  Google Scholar 

  11. Bochinski D, Lin GT, Nunes L et al (2004) The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 94(6):904–909

    Article  PubMed  Google Scholar 

  12. Fall PA, Izikki M, Tu L et al (2009) Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur Urol 56(4):716–725

    Article  PubMed  Google Scholar 

  13. Kendirci M, Spees JL, Trost L et al (2006) Adult bone marrow stem cells isolated by the p75 nerve growth factor receptor into the corpora cavernosa promoted recovery of erectile function in cavernous nerve injury. J Sex Med 3(Suppl 5):384 (Abstract OR-008)

    Google Scholar 

  14. Housman TS, Lawrence N, Mellen BG et al (2002) The safety of liposuction: results of a national survey. Dermatol Surg 28(11):971–978

    PubMed  Google Scholar 

  15. Strem BM, Hicok KC, Zhu M et al (2005) Multipotential differentiation of adipose tissue derived stem cells. Keio J Med 54(3):132–141

    Article  CAS  PubMed  Google Scholar 

  16. Albersen M, Fandel TM, Lin G et al (2010) Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7(10):3331–3340

    Article  PubMed  Google Scholar 

  17. Fandel TM, Albersen M, Lin G et al (2012) Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol 61(1):201–210

    Article  PubMed Central  PubMed  Google Scholar 

  18. Qiu X, Fandel TM, Ferretti L et al (2012) Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury. Eur Urol 62(4):720–727

    Article  PubMed Central  PubMed  Google Scholar 

  19. Castiglione F, Hedlund P, Van der Aa F et al (2013) Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie’s disease. Eur Urol 63(3):551–560

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Chamberlain G, Fox J, Ashton B, Middleton J (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25(11):2739–2749

    Article  CAS  PubMed  Google Scholar 

  21. Kumai Y, Kobler JB, Park H et al (2009) Crosstalk between adipose-derived stem/stromal cells and vocal fold fibroblasts in vitro. Laryngoscope 119:799–805

    Article  CAS  PubMed  Google Scholar 

  22. Kumai Y, Kobler JB, Park H et al (2010) Modulation of vocal fold scar fibroblasts by adipose-derived stem/stromal cells. Laryngoscope 120:330–337

    PubMed  Google Scholar 

  23. Huang W, Wang T, Zhang D et al (2012) Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9. Stem Cells Dev 21(5):778–789

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Cerruto MA, D’Elia C, Molinari A et al (2013) Animal experimental model of Peyronie’s disease: a pilot study. Arch Ital Urol Androl 85:28–33

    Article  PubMed  Google Scholar 

  25. Gokce A, Abd Elmageed ZY, Lasker GF et al (2014) Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie’s disease. Andrology 2(2):244–251

    Article  CAS  PubMed  Google Scholar 

  26. Zuk PA, Zhu M, Ashjian P et al (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279–4295

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  27. Katz AJ, Tholpady A, Tholpady SS et al (2005) Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells. Stem Cells 23:412–423

    Article  CAS  PubMed  Google Scholar 

  28. Rodbell M (1964) Metabolism of isolated fat cells. J Biol Chem 239:375–380

    CAS  PubMed  Google Scholar 

  29. Zuk PA, Zhu M, Mizuno H et al (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7(2):211–228

    Article  CAS  PubMed  Google Scholar 

  30. Bourin P, Bunnell BA, Casteilla L et al (2013) Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 15(6):641–648

    Article  PubMed Central  PubMed  Google Scholar 

  31. Nakagami H, Morishita R, Maeda K et al (2006) Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. J Atheroscler Thromb 13(2):77–81

    Article  PubMed  Google Scholar 

  32. Rehman J, Traktuev D, Li J et al (2004) Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109:1292–1298

    Article  PubMed  Google Scholar 

  33. Ailhaud G, Grimaldi P, Négrel R (1992) Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12:207–233

    Article  CAS  PubMed  Google Scholar 

  34. Gimble JM, Katz AJ, Bunnell BA (2007) Adipose-derived stem cells for regenerative medicine. Circ Res 100:1249–1260

    Article  CAS  PubMed  Google Scholar 

  35. Casteilla L, Planat-Benard V, Laharrague P et al (2011) Adipose-derived stromal cells: their identity and uses in clinical trials, an update. World J Stem Cells 3(4):25–33

    Article  PubMed Central  PubMed  Google Scholar 

  36. Mailey B, Hosseini A, Baker J et al (2014) Adipose-derived stem cells: methods for isolation and applications for clinical use. Methods Mol Biol 1210:161–181

    Article  PubMed  Google Scholar 

  37. Castiglione F, Albersen M, Di Trapani E et al (2014) Intratunical injection of autologous adipose stromal vascular fraction (SVF) prevents fibrosis in a rat model of Peyronie’s disease. 29th Annual Congress of the European Association of Urology Abstracts. Eur Urol Suppl 13(1):488

    Article  Google Scholar 

  38. Lander E, Berman M, See JR, California Stem Cell Treatment Center (2013) Autologous adipose derived stromal vascular fraction combined with low intensity shock wave therapy for the treatment of peyronies disease- a pilot study. Western Section-AUA annual meeting 2013, 3–7 Nov 2013, Monterey, poster n. 124-07-10. Available at: http://epostersonline.com/aua2013/?q=node/589&page=1

  39. Li ZJ, Choi HI, Choi DK et al (2012) Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg 38(7 Pt 1):1040–1046

    Article  CAS  PubMed  Google Scholar 

  40. Laudy AB, Bakker EW, Rekers M, Moen MH (2015) Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis. Br J Sports Med. In press.

    Google Scholar 

  41. An G, Ji C, Wei Z et al (2012) The therapeutic role of VEGF-expressing muscle-derived stem cells in acute penile cavernosal injury. J Sex Med 9(8):1988–2000

    Article  CAS  PubMed  Google Scholar 

  42. Levine LA, Larsen SM (2015) Surgical correction of persistent Peyronie’s disease following collagenase clostridium histolyticum treatment. J Sex Med 12:259–264

    Google Scholar 

  43. Levine LA, Cuzin B, Mark S et al (2015) Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie’s disease: a phase 3 open-label study. J Sex Med 12:248–258

    Google Scholar 

  44. Gelbard M, Goldstein I, Hellstrom et al (2013) Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol 190(1):199–207

    Article  CAS  PubMed  Google Scholar 

  45. Da Ros CT, Graziottin TM, Ribeiro E et al (2012) Long-term follow-up of penile curvature correction utilizing autologous albugineal crural graft. Int Braz J Urol 38(2):242–247; discussion 248–249

    Article  PubMed  Google Scholar 

  46. Schultheiss D, Lorenz RR, Meister R et al (2004) Functional tissue engineering of autologous tunica albuginea: a possible graft for Peyronie’s disease surgery. Eur Urol 45(6):781–786

    Article  PubMed  Google Scholar 

  47. Dessy LA, Mazzocchi M, Corrias F et al (2014) The use of cultured autologous oral epithelial cells for vaginoplasty in male-to-female transsexuals: a feasibility, safety, and advantageousness clinical pilot study. Plast Reconstr Surg 133(1):158–161

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gianni Paulis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Paulis, G., Cavallini, G., Alei, G. (2015). Future Perspectives in Peyronie’s Disease. In: Cavallini, G., Paulis, G. (eds) Peyronie’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-17202-6_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-17202-6_20

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17201-9

  • Online ISBN: 978-3-319-17202-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics