Abstract
Since its first discovery in 1930, immunohistochemistry (IHC) became a staple in all pathology departments. Its usage gained popularity in early 1970 when “immunoperoxidase” method to formalin paraffin-embedded tissues was developed. In recent days, this ancillary technology becomes a routine and essential tool in diagnostic and research laboratories. Application of IHC in medical practice is commonly used in helping to identify the origin of malignancy, predicting prognosis, and helping select targeted therapy. Gynecologic pathology is not an exception. Example and just to name a few, pair box gene 8 (PAX8) has been used to identify the Müllerian origin of a carcinoma, alpha-inhibin and calretinin for sex cord tumor. In this chapter, we will describe the principle and the interpretation of IHC, and we will discuss various immunomarkers that are commonly used in gynecologic pathology.
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Wang, Y., Mhawech-Fauceglia, P. (2016). Immunohistochemistry of Gynecologic Malignancies. In: Shoupe, D. (eds) Handbook of Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-319-17002-2_65-1
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DOI: https://doi.org/10.1007/978-3-319-17002-2_65-1
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