Abstract
Nanoparticles are being developed for several researches as well as for medicinal and engineering implications. Following them, a host of new potential health issues due to their size dependent larger surface area and high reactivity. In this chapter, an introduction on the likely interactions of nanoparticles with biotic environment, various possibilities of these man-made nanoparticles coming in contact with the environment, and thereby consequences will be discussed. This will be illustrated using our recent work on the effects of various sizes of engineered zinc oxide nanoparticles on the growth and viability of Escherichia coli and Bacillus subtilis. The relation between the growth inhibition and reactive oxygen species (ROS) generation and up- and/or down-regulation of transcriptional stress genome using E. coli and B. subtilis will be discussed. How zinc oxide nanoparticles were synthesized by solvent-free hydrothermal-based approach so as to eliminate cross-contaminants from the use of toxic solvents and surfactants. Further, utilization of advanced technique such as the transmission electron microscopy (TEM) and microarray-based transcriptional profiling to evaluate the bacterial response mechanisms will be described.
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Suresh, A.K. (2015). Toxicity of Metal Oxide Nanoparticles: Bactericidal Activity and Stress Response. In: Co-Relating Metallic Nanoparticle Characteristics and Bacterial Toxicity. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-16796-1_3
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DOI: https://doi.org/10.1007/978-3-319-16796-1_3
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