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Histone Deacetylase Functions in Epidermal Development, Homeostasis and Cancer

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Epigenetic Regulation of Skin Development and Regeneration

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Epigenetic mechanisms are essential for governing gene transcription and are vital to proper tissue development and homeostasis. Conversely, deregulation of these mechanisms can lead to disease development and progression. Histone deacetylases (HDACs) form a critical family of enzymes that remodel chromatin by removing acetylation marks from histone tails, causing chromatin compaction and a repressive transcriptional environment. HDACs can also remove acetyl moieties from other protein targets, including a subset of transcription factors, resulting in their altered stability and/or activity. Together, these functions allow HDACs to affect diverse cellular processes and direct cell fate. Global and tissue-specific deletion of individual Hdac genes in genetic mouse models has revealed their in vivo requirements for normal embryonic development and adult tissue functions. In this chapter we will discuss the roles played by HDACs in epithelial cells of the skin, an accessible model system for studying cell fate decisions during development, homeostasis, and disease.

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Acknowledgements

The authors thank Fang Liu for critically reading this manuscript.

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Authors and Affiliations

  1. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Donna M. Brennan-Crispi & Sarah E. Millar

  2. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sarah E. Millar

  3. Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sarah E. Millar

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  1. Donna M. Brennan-Crispi
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Correspondence to Sarah E. Millar .

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  1. Centre for Skin Sciences, University of Bradford, Bradford, UK

    Vladimir A. Botchkarev

  2. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sarah E. Millar

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Brennan-Crispi, D.M., Millar, S.E. (2018). Histone Deacetylase Functions in Epidermal Development, Homeostasis and Cancer. In: Botchkarev, V., Millar, S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_5

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