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Ischemic Stroke

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Biomarkers of Cardiometabolic Risk, Inflammation and Disease

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Abstract

In recent years, there was a surge in interest for biomarkers in ischemic stroke, with several purposes. In this chapter we will focus on biomarkers with potential use in ischemic stroke, namely, in diagnosis, grading of severity, identification of subtypes, and prediction of outcome or recurrence. A special emphasis will be placed on the role of inflammation in stroke, as it plays a key role in the cascade of events leading to progression of ischemic brain injury. However, the role of biomarkers in the clinical management of ischemic stroke is still limited. Therapeutic trials attempting to intervene on the inflammatory process are also briefly mentioned.

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Authors and Affiliations

  1. Department of Neurology, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal

    Ana Catarina Fonseca M.D., Ph.D., M.P.H. & Diana Aguiar de Sousa M.D., M.Sc.

  2. Department of Neurology, Hospital de Santa Maria, University of Lisbon, Avenida Professor Egas Moniz, 1649-035, Lisbon, Portugal

    José M. Ferro M.D., Ph.D.

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  1. Ana Catarina Fonseca M.D., Ph.D., M.P.H.
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  2. Diana Aguiar de Sousa M.D., M.Sc.
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  3. José M. Ferro M.D., Ph.D.
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Correspondence to José M. Ferro M.D., Ph.D. .

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Editors and Affiliations

  1. Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, Coimbra University, Coimbra, Portugal

    Filipe Palavra

  2. Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, Coimbra University, Coimbra, Portugal

    Flávio Reis

  3. Department of Internal Medicine – B, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

    Daniela Marado

  4. Interdisciplinary Centre of Research Egas Moniz, CiiEM, Caparica, Portugal

    Armando Sena

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Fonseca, A.C., de Sousa, D.A., Ferro, J.M. (2015). Ischemic Stroke. In: Palavra, F., Reis, F., Marado, D., Sena, A. (eds) Biomarkers of Cardiometabolic Risk, Inflammation and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-16018-4_4

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