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Valvular Heart Disease: Introduction, Clinical Pathogenesis, and Management

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Pathophysiology and Pharmacotherapy of Cardiovascular Disease

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Abstract

Valvular heart disease (VHD) is a common cardiac condition with a big impact on healthcare economics. The incidence of VHD had been increasing over the past few decades, likely due to aging population [1]; improved mortality outcomes with increased survival in patients with conditions such as ischemic heart disease, chronic kidney disease, inflammatory disease states, and oncologic patients; earlier diagnoses due to technologic advances in imaging tools; and iatrogenic valve disease such as prosthetic valve dysfunction [2]. It is important to have an in-depth understanding of the different types of VHD; the natural history; interplay between anatomic, genetic, and molecular mechanisms of specific VHD; impact of VHD on other organ systems; and advances in diagnostic and therapeutic options that will translate to improved patient outcomes [3].

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Feinberg Pavilion, Suite 8-503G, 201 E. Huron St, Chicago, IL, 60611, USA

    Siri Kunchakarra MD, Jyothy Puthumana MD & Kameswari Maganti MD

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  1. Siri Kunchakarra MD
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  2. Jyothy Puthumana MD
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Correspondence to Kameswari Maganti MD .

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  1. Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, Maryland, USA

    Gowraganahalli Jagadeesh

  2. Pharmacology Unit, AIMST University, Bedong, Malaysia

    Pitchai Balakumar

  3. Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, Maryland, USA

    Khin Maung-U

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Kunchakarra, S., Puthumana, J., Maganti, K. (2015). Valvular Heart Disease: Introduction, Clinical Pathogenesis, and Management. In: Jagadeesh, G., Balakumar, P., Maung-U, K. (eds) Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Adis, Cham. https://doi.org/10.1007/978-3-319-15961-4_54

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  • DOI: https://doi.org/10.1007/978-3-319-15961-4_54

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-15960-7

  • Online ISBN: 978-3-319-15961-4

  • eBook Packages: MedicineMedicine (R0)

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