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Oral Solids

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Practical Pharmaceutics

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Abstract

This chapter provides the pharmaceutical basis of common solid dosage forms and discusses biopharmaceutical aspects related to their formulation. There is a need for customised capsules and powders, usually when the required dose is not available as a licensed product and this dose cannot be obtained by splitting of tablets, as it is in paediatrics. Swallowing problems may be another reason. The aspects related to the excipients to be used and factors affecting the processing of materials, and thus, the performance of the final product are discussed in this chapter. The design of formulations and quality control of powders and capsules are presented in detail. Attention is also given to a specific area of solid dosage forms namely, cachets and herbal teas.

The pharmacist can prepare capsules or powders from the pure active substance or, when this is not available, from pulverised tablets and the contents of higher dosed capsules. Non-coated tablets can usually be pulverised. Modified-release tablets or enteric-coated tablets can be processed in only a limited number of cases. Critical steps in the preparation of solid oral dosage forms are discussed which are the preparation of a homogeneous powder mixture and evenly dividing the powder mixture over the dosage units.

Based upon the chapter Oral Solids by Christien Oussoren and Gerad Bolhuis in the 2009 edition of Recepteerkunde.

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Notes

  1. 1.

    This section was contributed by Herman J. Woerdenbag, Groningen, The Netherlands.

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Author information

Authors and Affiliations

  1. Department of Pharmacy, Kuopio University Hospital, 100, KYS FI-70029, Kuopio, Finland

    Minna Helin-Tanninen

  2. Department of Pharmaceutics and Pharmaceutical Technology, University of Lisbon, Av. Prof. Gama Pinto, 1640–003, Lisbon, Portugal

    João Pinto

Authors
  1. Minna Helin-Tanninen
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  2. João Pinto
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Correspondence to Minna Helin-Tanninen .

Editor information

Editors and Affiliations

  1. Laboratory of Dutch Pharmacists, Royal Dutch Pharmacists Association KNMP, The Hague, The Netherlands

    Yvonne Bouwman-Boer

  2. Former Quality Control Pharmacist to the Welsh Hospitals, Cardiff, United Kingdom

    V'Iain Fenton-May

  3. The Hague Hospital Pharmacy, The Hague, The Netherlands

    Paul Le Brun

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Helin-Tanninen, M., Pinto, J. (2015). Oral Solids. In: Bouwman-Boer, Y., Fenton-May, V., Le Brun, P. (eds) Practical Pharmaceutics. Springer, Cham. https://doi.org/10.1007/978-3-319-15814-3_4

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  • DOI: https://doi.org/10.1007/978-3-319-15814-3_4

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15813-6

  • Online ISBN: 978-3-319-15814-3

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