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Rationalizing the Biodegradation of Glasses for Biomedical Applications Through Classical and Ab-initio Simulations

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Molecular Dynamics Simulations of Disordered Materials

Part of the book series: Springer Series in Materials Science ((SSMATERIALS,volume 215))

Abstract

The gradual dissolution of a glass in a living host determines the rate at which processes leading to tissue regeneration can occur, which is of crucial importance for the success of biomedical implants and scaffolds for tissue engineering based on the glass. In-situ radiotherapy applications are also affected—in an opposite way—by the rate at which the glass vector used to deliver radioisotopes will degrade in the bloodstream. This chapter illustrates how a combination of classical and ab-initio simulations techniques, mainly centred on Molecular Dynamics, can shed new light into structural and dynamical features that control the biodegradation of these materials.

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Authors and Affiliations

  1. Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK

    Antonio Tilocca

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  1. Antonio Tilocca
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Editors and Affiliations

  1. IPCMS, Strasbourg University, Strasbourg, France

    Carlo Massobrio

  2. Dept. of Materials Science and Engineeri, University of North Texas, Denton, Texas, USA

    Jincheng Du

  3. Dept. of Materials Science, University of Milan Bicocca, Milan, Italy

    Marco Bernasconi

  4. Dept. of Physics, University of Bath, Bath, United Kingdom

    Philip S. Salmon

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Tilocca, A. (2015). Rationalizing the Biodegradation of Glasses for Biomedical Applications Through Classical and Ab-initio Simulations. In: Massobrio, C., Du, J., Bernasconi, M., Salmon, P. (eds) Molecular Dynamics Simulations of Disordered Materials. Springer Series in Materials Science, vol 215. Springer, Cham. https://doi.org/10.1007/978-3-319-15675-0_10

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