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Helminth-Induced IgE and Protection Against Allergic Disorders

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IgE Antibodies: Generation and Function

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 388))

Abstract

The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries.

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Authors and Affiliations

  1. Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

    Firdaus Hamid

  2. Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands

    Firdaus Hamid, Abena S. Amoah & Maria Yazdanbakhsh

  3. Department of Parasitology, Noguchi Memorial Institute for Medical Research, Accra, Ghana

    Abena S. Amoah

  4. Department of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical Center, Amsterdam University, Amsterdam, The Netherlands

    Ronald van Ree

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  1. Firdaus Hamid
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  2. Abena S. Amoah
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  3. Ronald van Ree
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  4. Maria Yazdanbakhsh
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Correspondence to Maria Yazdanbakhsh .

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Editors and Affiliations

  1. Skirball Institute and Department of Pathology, New York University School of Medicine, New York, USA

    Juan J. Lafaille

  2. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore

    Maria A. Curotto de Lafaille

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Hamid, F., Amoah, A.S., van Ree, R., Yazdanbakhsh, M. (2015). Helminth-Induced IgE and Protection Against Allergic Disorders. In: Lafaille, J., Curotto de Lafaille, M. (eds) IgE Antibodies: Generation and Function. Current Topics in Microbiology and Immunology, vol 388. Springer, Cham. https://doi.org/10.1007/978-3-319-13725-4_5

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