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Smoking Abstinence and Neurocognition: Implications for Cessation and Relapse

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The Neurobiology and Genetics of Nicotine and Tobacco

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 23))

Abstract

In this chapter, we review the last decade of research on the effects of smoking abstinence on various forms of neurocognition, including executive function (working memory, sustained attention, response inhibition), reward processing, and cue-reactivity. In our review we identify smoking abstinence-induced deficits in executive function mediated by effects on frontal circuitry, which in turn is known to be affected by modulation of cholinergic, dopaminergic, and other neurotransmitter systems. We also review evidence that smoking abstinence blunts reactivity to non-drug reinforcers—a finding that is consistent with results in the animal literature. Finally, our review of cue-reactivity indicates that smoking abstinence does not appear to amplify cue-provoked craving, although it may increase attentional bias to smoking-related cues. Inconsistencies across findings and potential contributing factors are discussed. In addition, we review the literature on the effects of nicotine and non-nicotine factors in neurocognition. Finally, we provide a multi-factor model and an agenda for future research on the effects of smoking abstinence on neurocognition. The model includes four distinct yet interacting factors, including: Negative Reinforcement, Drug-Reward Bias, Goal and Skill Interference, and Non-Cognitive Factors. Additional research is needed to further evaluate the scope and time-course of abstinence-induced changes in neurocognition, the mechanisms that underlie these changes and the specific role of these processes in drug reinforcement, lapse, and relapse.

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Acknowledgments

Funding: NIDA grants R01 DA025876 (FJM), R01 DA024838 (FJM) and K01 DA033347 (MAA).

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 2608 Erwin Rd Box 3527, Lakeview Pavilion E Ste 300, Durham, NC, 27705-4596, USA

    F. Joseph McClernon, Merideth A. Addicott & Maggie M. Sweitzer

  2. Duke-UNC Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, USA

    F. Joseph McClernon, Merideth A. Addicott & Maggie M. Sweitzer

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  1. F. Joseph McClernon
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  2. Merideth A. Addicott
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  3. Maggie M. Sweitzer
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Correspondence to F. Joseph McClernon .

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  1. Ninewells Hospital, University of Dundee Medical School, Dundee, United Kingdom

    David J.K. Balfour

  2. School of Experimental Psychology, University of Bristol, Bristol, United Kingdom

    Marcus R. Munafò

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McClernon, F.J., Addicott, M.A., Sweitzer, M.M. (2015). Smoking Abstinence and Neurocognition: Implications for Cessation and Relapse. In: Balfour, D., Munafò, M. (eds) The Neurobiology and Genetics of Nicotine and Tobacco. Current Topics in Behavioral Neurosciences, vol 23. Springer, Cham. https://doi.org/10.1007/978-3-319-13665-3_8

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