Abstract
The novel biophysical model was updated to de-scribe the calcium (Ca2 + ) dynamics and contraction force in rat cardiac myocyte. The influence of calcium buffers and the mitochondrial sodium calcium exchanger (NCLX) in the exci-tation-contraction coupling were studied. Simulations showed that these mechanisms impact directly on the ryanodine recep-tors by influencing the Ca2 + release from the sarcoplasmic reticulum, altering the Ca2 + transient and, consequently, the contraction force in cardiac myocyte.
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© 2015 Springer International Publishing Switzerland
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Silva, E.T.N.T., Silva, R.R., Goroso, D.G. (2015). Computer Simulations on the Influence of NCLX and Buffers Calcium in Rat Cardiac Myocyte. In: Braidot, A., Hadad, A. (eds) VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paraná, Argentina 29, 30 & 31 October 2014. IFMBE Proceedings, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-319-13117-7_217
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DOI: https://doi.org/10.1007/978-3-319-13117-7_217
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-13116-0
Online ISBN: 978-3-319-13117-7
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