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Dose-Response Assessment

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Toxicological Risk Assessment for Beginners

Abstract

The goal of dose-response assessment is to quantitatively describe the relationship between the extent of exposure (the dose) and the likelihood of adverse health effects (responses). The outcome of dose-response assessment is a value which, when combined with the exposure estimate, will allow an estimation of health risk. Key tasks in dose-response assessment are the compilation of dose-response data from animal and human toxicology studies, selection of the most sensitive and convincing health effects or endpoints, identification of a suitable no or minimal effect dose associated with those effects, and selection of uncertainty factors and dose-response models that can be used to derive a safe level for human exposure.

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Notes

  1. 1.

    USEPA, 1993. Reference Dose (RfD): Description and Use in Health Risk Assessments Background Document 1A March 15, 1993. http://www.epa.gov/iris/rfd.htm.

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Author information

Authors and Affiliations

  1. Gradient, 600 Stewart Street, Suite 1900, 98101, Seattle, WA, USA

    Thomas A. Lewandowski PhD, DABT, ERT

  2. New York, NY, USA

    John Norman PhD, JD

Authors
  1. Thomas A. Lewandowski PhD, DABT, ERT
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  2. John Norman PhD, JD
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Correspondence to Thomas A. Lewandowski PhD, DABT, ERT .

Editor information

Editors and Affiliations

  1. Independent Toxicology Consultant, Denton, Texas, USA

    José A. Torres

  2. Nexeo Solutions, Houston, Texas, USA

    Sol Bobst

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Lewandowski, T., Norman, J. (2015). Dose-Response Assessment. In: Torres, J., Bobst, S. (eds) Toxicological Risk Assessment for Beginners. Springer, Cham. https://doi.org/10.1007/978-3-319-12751-4_3

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