Abstract
Heparin therapy is one of the most common forms of medical intervention. It is the mainstay of treatment and prevention of thrombosis in diverse clinical settings, including acute venous thromboembolism, atrial fibrillation, and acute coronary syndrome and in patients undergoing invasive cardiac procedures. Unfractionated heparin had been the standard of anticoagulation for most of the twentieth century. However, more recently the development of low-molecular-weight heparins (LMWHs) represents a refinement for the use of heparin. Low-molecular-weight heparins and fondaparinux, a synthetic analog, have displaced unfractionated heparin for many indications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Barbour LA, Kick SD, Steiner JF, LoVerde ME, Heddleston LN, Lear JL, Baron AE, Bartón PL. A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry. Am J Obstet Gynecol. 1994;170(3):862–9.
Bulas DI, Taylor GA, Fitz CR, Revenis ME, Glass P, Ingram JD. Posterior fossa intracranial hemorrhage in infants treated with extracorporeal membrane oxygenation: sonographic findings. AJR Am J Roentgenol. 1991;156(3):571–5.
Crowther MA, Warkentin TE. Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents. Blood. 2008;111(10):4871–9.
Fareed J, Hoppensteadt DA, Bick RL. An update on heparins at the beginning of the new millennium. Semin Thromb Hemost. 2000;26(s1):5–22.
Garcia DA, Baglin TP, Weitz JI, Samama MM. Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):e24S–43.
Griffith GC, Nichols JD, Flanagan B. Heparin osteoporosis. J Am Med Assoc. 1965;196:85–8.
Madhugiri VS, Mahadevan A, Gundamaneni SK, Singh M. Heparin-induced tumour bleed. BMJ Case Rep. 2012;2012.
Pohl C, Klockgether T, Greinacher A, Hanfland P, Harbrecht U. Neurological complications in heparin-induced thrombocytopenia. Lancet. 1999;353:1678–9.
Quinones-Hinojosa A, Gulati M, Singh V, Lawton MT. Spontaneous intracerebral hemorrhage due to coagulation disorders. Neurosurg Focus. 2003;15(4):E3.
Resnick SB, Resnick SH, Weintraub JL, Kothary N. Heparin in interventional radiology: a therapy in evolution. Semin Intervent Radiol. 2005;22(2):95–107.
Roob G, Fazekas F. Magnetic resonance imaging of cerebral microbleeds. Curr Opin Neurol. 2000;13:69–73.
Sackler JP, Liu L. Heparin-induced osteoporosis. Br J Radiol (Impact Factor: 131). 1973;46(547):548–50.
Weitz DS, Weitz JI. Update on heparin: what do we need to know? J Thromb Thrombolysis. 2010;29(2):199–207.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Watkins, E., Ginat, D.T. (2015). Heparin. In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_33
Download citation
DOI: https://doi.org/10.1007/978-3-319-12715-6_33
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12714-9
Online ISBN: 978-3-319-12715-6
eBook Packages: MedicineMedicine (R0)