Abstract
High level of fluoride (F) in drinking water has been recognized as a potential health hazard all over the world. In India, 17 out of 32 states have been identified as ‘endemic’ areas for fluorosis, with an estimated 25 million people impacted, and another 66.62 million people (including six million children below the age of 14) ‘at risk’ of facing health hazards due to high water-borne fluoride concentrations. After ingestion of fluoridated water, majority of the fluoride is absorbed from the stomach and small intestine into the blood stream (Whitford 1996). Approximately, 50 % of the fluoride absorbed each day by young or middle-aged adults becomes associated with hard tissues (teeth and bones) within 24 h while virtually all of the remainder is excreted (Whitford 1996). More fluoride is retained in young bones than in the bones of older adults (Whitford 1996; Horowitz 1996). Fluoride toxicity at high levels has also been associated with thyroid changes, growth retardation, kidney changes, and even urolithiasis (Dhar and Bhatnagar 2009). According to Strunecka et al. (2007), fluoride in excess amounts causes several ailments viz, metabolic disturbances, endocrine dysfunctions and physiological alterations in the body. F exposure also disrupts the synthesis of collagen and leads to the breakdown of collagen in bones (Susheela and Jha 1981). Its excessive intake may result in slow, progressive crippling condition known as fluorosis. This paper reports about the groundwater quality of certain regions of Gaya district of Bihar, with special emphasis on fluoride contamination and its impact on human health.
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References
APHA (1995) Standard methods for the examination of water and wastewater, 19th edn. American Public Health Association, Washington, DC
Bălan H (2012) Fluoride – the danger that we must avoid. J Intern Med 50(1):61–69
Barot VV (1998) Occurrence of endemic fluorosis in human population of North Gujarat, India: human health risk. Bull Environ Contam Toxicol 61:303–310
Das TK, Susheela AK, Gupta IP, Dasarathy S, Tandon RK (1994) Toxic effects of chronic fluoride ingestion on upper gastro-intestinal tract. J Clin Gastroenterol 18:194–199
Das B, Talukdar J, Sarma S, Gohain B, Dutta RK, Dutta HB, Das SC (2003) Fluoride and other inorganic constituents in groundwater of Guwahati, Assam, India. Curr Sci 85(5):657–661
Dhar V, Bhatnagar M (2009) Physiology and toxicity of fluoride. Indian J Dent Res 20(3):350–355
Fowles JR, Fairbrother A, Kerkvliet NI (1997) Effect of induced hypo- and hyperthyroidism on immune function and plasma biochemistry in mallards. Comp Biochem Physiol 118:213–220
Ge YM, Ning HM, Wang SL, Wang JD (2005a) Comet assay of DNA damage in brain cells of adult rats exposed to high fluoride and low iodine. Fluoride 38:209–214
Ge YM, Ning HM, Wang SL, Wang JD (2005b) DNA damage in thyroid gland cells of rats exposed to long term intake of high fluoride and low iodine. Fluoride 38:318–323
Handa BK (1975) Geochemistry and genesis of fluoride containing groundwater in India. Ground Water 13:275–281
Hileman B (1988) Fluoridation of water: questions about health risks and benefits remain after more than 40 years. Chem Eng News 26–42
Horowitz HS (1996) The effectiveness of community water fluoridation in the United States. J Public Health Dent 56:253–258
Jafarzadeh A, Poorholami M, Izadi N, Nemati M, Rezayati M (2010) Immunological and haematological changes in patients with hyperthyroidism or hypothyroidism. Clin Invest Med 33(5):E271–E279
Liu GY, Chai CY, Kang SL (2002) Effects of fluoride on ultrastructure of thyroid in chicks. Chin J Vet Sci 22:512–514 (in Chinese)
Michael M, Barot VV, Chinoy NJ (1996) Investigations of soft tissue functions in fluorotic individuals of North Gujarat. Fluoride 29(2):63–71
O’malley LSS (2007) Bengal district gazetteer: Gaya. Concept Publishing Company
Saxena VK, Ahmed S (2001) Dissolution of fluoride in groundwaters: a water-rock interaction study. Environ Geol 40:1084–1087
Sharma JD, Sohu D, Jain P (2009) Prevalence of neurological manifestations in a human population exposed to fluoride in drinking water. Fluoride 42(2):127–132
Spittle B (1994) Psychopharmacology of fluoride: a review. Int Clin Psychopharmacol 9:79–82
Strunecka A, Patocka J, Blaylock RL, Chinoy NJ (2007) Fluoride interactions: from molecules to disease. Curr Signal Transduct Ther 2:190–213
Sunitha V, Muralidhara Reddy B, Ramakrishna Reddy M (2012) Variation of fluoride and correlation with alkalinity in groundwater of shallow and deep aquifers—a case study in and around Anantapur district, Andhra Pradesh. Int J Appl Sci Eng Res 1(4):569–575
Susheela AK, Jain SK (1983) Fluoride-induced hematological changes in rabbits. Bull Environ Contam Toxicol 30:388–393
Susheela AK, Jha M (1981) Effect of Fluoride on cortical and cancellous bone composition. IRCS Med Sci: Library Compend 9(11):1021–1022
Susheela AK, Das TK, Gupta IP, Tandon RK, Kacker SK, Ghosh P, Deka RC (1992) Fluoride ingestion and its correlation with gastro-intestinal discomfort. Fluoride 25:5–22
Susheela AK, Bhatnagar M, Vig K, Mondal NK (2005) Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India. Fluoride 38:98–108
Susheela AK, Mondal NK, Gupta R, Ganesh K, Brahmankar S, Bhasin S, Gupta G (2010) Effective interventional approach to control anaemia in pregnant women. Curr Sci 98(10):1320–1330
Viswanathan G, Jaswanth A, Gopalakrishnan S, Siva Ilango S (2009) Mapping of fluoride endemic areas and assessment of fluoride exposure. Sci Total Environ 407(5):1579–1587
Whitford GM (1996) The metabolism and toxicity of fluoride, 2nd revised edn, Monographs in oral science, vol 16. Karger, Basel
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We are grateful to UGC for the financial support under the Major Project Scheme and to Dr. Sister Doris D’Souza, Principal, Patna Women’s College for providing the necessary facilities.
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Yasmin, S., Ranjan, S. (2015). Fluoride Toxicity in the Fluoride Endemic Villages of Gaya District, Bihar, India. In: Raju, N., Gossel, W., Sudhakar, M. (eds) Management of Natural Resources in a Changing Environment. Springer, Cham. https://doi.org/10.1007/978-3-319-12559-6_22
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