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Polymers in Wound Repair

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Advanced Polymers in Medicine

Abstract

Efficient dermal wound care implies providing a healing environment at the site of injury. Current repair techniques, including polymeric dressings, are able to accelerate only the healing of epidermal and partial thickness acute wounds based on maintaining the area moist. However, these are not efficient in treatment of full-thickness and chronic wounds, which lack in inborn regenerative elements and are highly prone to infections. For this reason the research interest is nowadays shifted towards functional biomaterials to tackle severe skin deteriorations by providing a beneficiary for healing pro-active and pathogen-free environment. Recent advances in molecular biology and materials science together with better understanding of wound pathophysiology allowed for designing of new wound care approaches that rely on biochemical stimuli to promote wound closure. Biopolymers that couple intrinsic antimicrobial and wound repair properties with hydrophilicity appear as suitable dressing platforms. These can be further upgraded using various bio-entities (therapeutic molecules, cells) with the ability to address specific targets in the biochemical environment of wounds in order to stimulate the healing process. This chapter summarises the abundant experimental and clinical data on polymers in advanced wound dressings, scaffolds for dermal regeneration and platforms for drug delivery.

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Abbreviations

bFGF:

Basic fibroblast growth factor

BSA:

Bovine serum albumin

ECM:

Extracellular matrix

GAGs:

Glycosaminoglycans

GM-CSF:

Granulocyte macrophage colony stimulating factor

HA:

Hyaluronic acid

HClO:

Hypochlorous acid

MMPs:

Matrix metalloproteinases

MPO:

Myeloperoxidase

NPWT:

Negative pressure wound therapy

PDGF-BB:

Platelet-derived growth factor BB

PRP:

Platelet rich plasma

PHMB:

Polyhexamethylene biguanide

ROS:

Reactive oxygen species

SF:

Silk fibroin

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Grup de Biotecnologia Molecular i Industrial, Edifici Gaia, Department of Chemical Engineering, Universitat Politècnica de Catalunya, Rambla Sant Nebridi, 22, 08222, Terrassa, Spain

    Antonio Francesko, Margarida M. Fernandes & Tzanko Tzanov

  2. KitoZyme S.A., Parc Industriel Des Hauts-Sarts, Zone 2, Rue Haute Claire 4, 4040, Herstal, Belgium

    Guillem Rocasalbas & Sandrine Gautier

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  1. Antonio Francesko
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  2. Margarida M. Fernandes
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  3. Guillem Rocasalbas
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  4. Sandrine Gautier
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  5. Tzanko Tzanov
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Correspondence to Tzanko Tzanov .

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  1. Pharmacy, Health and Nutritional Sci., University of Calabria, Rende, Italy

    Francesco Puoci

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Francesko, A., Fernandes, M.M., Rocasalbas, G., Gautier, S., Tzanov, T. (2015). Polymers in Wound Repair. In: Puoci, F. (eds) Advanced Polymers in Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-12478-0_14

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