Abstract
Cortical Theta burst stimulation (TBS) may modulate dopamine-dependent corticostriatal plasticity via long-term potentiation / depression (LTP/LTD) -like mechanism. This gives TBS a therapeutic potential for Parkinson,’s disease (PD) and other neural disorder. To unravel the mechanism beneath TBS-induced neuroplasticity, a novel optogenetic simulating method will be applied. CaMKII promoter-driven channelrhodopsin-2 (ChR2) will be delivered into glutamatergic pyramidal neuron in motor cortex by lentivirus. Under emitting of precisely controlled blue laser guided by fiber optics, the excitatory circuit in layer V will be elicited with TBS paradigm. Cortical excitabilities were examined by measuring optogenetic simulation-evoked potential and motor-evoked potential (MEP). In summary, we proposed a novel optical-TBS rodent model, which revealed the function role of glutamatergic circuit in motor plasticity.
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© 2015 Springer International Publishing Switzerland
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Wu, CW., Hsieh, CH., Chen, JJ.J. (2015). Optogenetic Deconstructing the Mechanism of Neuroplasticity Modulated by Repetitive Cortical Stimulation. In: Su, FC., Wang, SH., Yeh, ML. (eds) 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 47. Springer, Cham. https://doi.org/10.1007/978-3-319-12262-5_72
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DOI: https://doi.org/10.1007/978-3-319-12262-5_72
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12261-8
Online ISBN: 978-3-319-12262-5
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