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Cognitive Psychology and Neuropsychology of Nociception and Pain

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Pain, Emotion and Cognition

Abstract

For a long time, pain research has focused on understanding the mechanisms underlying the unpleasant experience generated by a nociceptive stimulus. Cognitive theories emphasize the functional aspects of nociception by defining it as a warning process. Nociceptive inputs are processed in a multisensory processing system that prioritizes stimuli that are meaningful for the integrity of the body and integrates them into multi-frame representations of the body and the proximal space. The ultimate purpose of this multisensory system is to guide defensive behaviors. Recent experimental evidence supports the role that cognitive functions such as selective attention, spatial perception, and motor preparation play in nociceptive processing. In addition, the cognitive approach of pain offers new clinical perspectives by providing a framework for the treatment of chronic pain based on neuropsychological rehabilitation.

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References

  • Acerra NE, Moseley GL (2005) Dysynchiria: watching the mirror image of the unaffected limb elicits pain on the affected side. Neurology 65:751–753

    PubMed  Google Scholar 

  • Algoet M, Duqué J, Iannetti GD, Mouraux A (2013) Temporal dynamics and specificity of the motor responses to a transient nociceptive stimulus in humans. Poster presented at the 8th Congress of the European Pain Federation (EFIC), Florence, 9–12 Oct 2013

    Google Scholar 

  • Allport A (1987) Selection for action: some behavioral and neurophysiological considerations of attention and action. In: Heuer H, Sanders AF (eds) Perspectives on perception and action. Erlbaum, Hillsdale, pp 395–419

    Google Scholar 

  • Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I (2002) Imaging how attention modulates pain in humans using functional MRI. Brain 125:310–319

    PubMed  Google Scholar 

  • Boisacq-Schepens N, Crommelinck M (1996) Neuro-psycho-physiologie. 2. Comportement, 3rd edn. Masson, Paris

    Google Scholar 

  • Broadbent DE (1958) Perception and communication. Pergamon Press, Oxford

    Google Scholar 

  • Bultitude JH, Rafal RD (2010) Derangement of body representation in complex regional pain syndrome: report of a case treated with mirror and prisms. Exp Brain Res 204:409–418

    PubMed Central  PubMed  Google Scholar 

  • Crollen V, Collignon O (2012) Embodied space in early blind individuals. Front Psychol 3:272

    PubMed Central  PubMed  Google Scholar 

  • Crombez G, Baeyens F, Eelen P (1994) Sensory and temporal information about impending pain: the influence of predictability on pain. Behav Res Ther 32:611–622

    CAS  PubMed  Google Scholar 

  • Crombez G, Eccleston C, Baeyens F, Eelen P (1996) The disruptive nature of pain: an experimental investigation. Behav Res Ther 34:911–918

    CAS  PubMed  Google Scholar 

  • Crombez G, Eccleston C, Baeyens F, Eelen P (1997) Habituation and interference of pain with task performance. Pain 70:149–154

    CAS  PubMed  Google Scholar 

  • De Paepe AL, Crombez G, Legrain V (2014a) Beyond the somatotopic organization of pain: evidence for a peripersonal frame of reference during the localization of nociceptive stimuli. Poster presented at the 8th Congress of the European Pain Federation (EFIC), Florence, 9–12 Oct 2013

    Google Scholar 

  • De Paepe AL, Crombez G, Spence C, Legrain V (2014b) Mapping nociceptive stimuli in a peripersonal frame of reference: evidence from a temporal order judgment task. Neuropsychologia 56:219–228

    PubMed  Google Scholar 

  • Desimone R, Duncan J (1995) Neural mechanisms of selective visual attention. Annu Rev Neurosci 18:193–222

    CAS  PubMed  Google Scholar 

  • Dong WK, Chudler EH, Sugiyama K, Roberts VJ, Hayashi T (1994) Somatosensory, multisensory, and task-related neurons in cortical area 7b (PF) of unanesthetized monkeys. J Neurophysiol 72:543–564

    Google Scholar 

  • Downar J, Mikulis DJ, Davis KD (2003) Neural correlates of the prolonged salience of painful stimulation. Neuroimage 20:1540–1551

    PubMed  Google Scholar 

  • Eccleston C, Crombez G (1999) Pain demands attention: a cognitive-affective model of the interruptive function of pain. Psychol Bull 125:356–366

    CAS  PubMed  Google Scholar 

  • Egeth HE, Yantis S (1997) Visual attention: control, representation, and time course. Annu Rev Psychol 48:269–297

    CAS  PubMed  Google Scholar 

  • Filevitch E, Haggard P (2012) Grin and bear it! Neural consequences of a voluntary decision to act or inhibit action. Exp Brain Res 223:341–351

    Google Scholar 

  • Folk CL, Remington RW, Johnston JC (1992) Involuntary covert orienting is contingent on attentional control settings. J Exp Psychol Hum Percept Perform 18:1030–1044

    CAS  PubMed  Google Scholar 

  • Förderreuther S, Sailer U, Straube A (2004) Impaired self-perception of the hand in complex regional pain syndrome (CRPS). Pain 110:756–761

    PubMed  Google Scholar 

  • Frettlöh J, Hüppe M, Maier C (2006) Severity and specificity of neglect-like symptoms in patients with complex regional pain syndrome (CRPS) compared to chronic limb pain of other origins. Pain 124:184–189

    PubMed  Google Scholar 

  • Frot M, Magnin M, Mauguière F, Garcia-Larrea L (2012) Cortical representation of pain in primary sensory-motor areas (SI/MI) – a study using intracortical recordings in humans. Hum Brain Mapp 34:2655–2668

    PubMed  Google Scholar 

  • Galer BS, Jensen M (1999) Neglect-like symptoms in complex regional pain syndrome: results of a self-administrated survey. J Pain Symptom Manage 18:213–217

    CAS  PubMed  Google Scholar 

  • Gallace A, Torta DM, Moseley GL, Iannetti GD (2011) The analgesic effect of crossing the arms. Pain 152:1418–1423

    CAS  PubMed  Google Scholar 

  • Gelnar PA, Krauss BR, Sheehe PR, Szeverenyi NM, Apkarian AV (1999) A comparative fMRI study of cortical representations for thermal painful, vibrotactile, and motor performance tasks. Neuroimage 10:460–482

    CAS  PubMed  Google Scholar 

  • Graziano MSA, Cooke DF (2006) Parieto-frontal interactions, personal space, and defensive behavior. Neuropsychologia 44:2621–2635

    PubMed  Google Scholar 

  • Graziano MSA, Gross CG, Taylor CSR, Moore T (2004) A system of multimodal areas in the primate brain. In: Spence C, Driver J (eds) Crossmodal space and crossmodal attention. Oxford University Press, Oxford, pp 51–67

    Google Scholar 

  • Hadjistavropoulos HD, Hadjistavropoulos T, Quine A (2000) Health anxiety moderates the effects of distraction versus attention to pain. Behav Res Ther 38:425–438

    CAS  PubMed  Google Scholar 

  • Haggard P, Iannetti GD, Longo MR (2013) Spatial sensory organization and body representation in pain perception. Curr Biol 23:R164–R176

    CAS  PubMed  Google Scholar 

  • Harvey AG, McGuire BE (2000) Suppressing and attending to pain-related thoughts in chronic pain patients. Behav Res Ther 38:1117–1124

    CAS  PubMed  Google Scholar 

  • Holmes NP, Spence C (2004) The body schema and multisensory representation(s) of peripersonal space. Cogn Process 5:94–105

    PubMed Central  PubMed  Google Scholar 

  • Hommel B (2010) Grounding attention in action controls: the intentional control of selection. In: Bruya B (ed) Effortless attention. A new perspective in the cognitive science of attention and action. MIT press, Cambridge, pp 121–140

    Google Scholar 

  • Honoré J, Hénon H, Naveteur J (1995) Influence of eye orientation on pain as a function of anxiety. Pain 63:213–218

    PubMed  Google Scholar 

  • Hu L, Zhao C, Li H, Valentini E (2013) Mismatch responses evoked by nociceptive stimuli. Psychophysiology 50:158–173

    CAS  PubMed  Google Scholar 

  • Iannetti GD, Hughes NP, Lee MC, Mouraux A (2008) Determinants of laser-evoked EEG responses: pain perception or stimulus saliency? J Neurophysiol 100:815–828

    PubMed Central  CAS  PubMed  Google Scholar 

  • Itti L, Koch C (2001) Computational modelling of visual attention. Nat Rev Neurosci 2:194–203

    CAS  PubMed  Google Scholar 

  • Jacquin-Courtois S, Legrain V, Sumitani M, Miyauchi S, Rossetti Y (2012) Visuo-motor adaptation and bodily representations: from neglect to complex regional pain syndrome. Let Med Phys Readapt 28:93–98

    Google Scholar 

  • James W (1890) The principles of psychology. H Holt and Co., New York (edition of 1950 by Dover Publications, New York)

    Google Scholar 

  • Johnson MH, Petrie SM (1997) The effects of distraction on exercise and cold pressor tolerance for chronic low back pain sufferers. Pain 69:43–48

    CAS  PubMed  Google Scholar 

  • Knudsen EI (2007) Fundamental components of attention. Annu Rev Neurosci 30:57–78

    CAS  PubMed  Google Scholar 

  • Kolbe L, Lang S, Maihöfner C (2012) Cognitive correlates of “neglect-like syndrome” in patients with complex regional pain syndrome. Pain 153:1063–1073

    Google Scholar 

  • Krause P, Förderreuther S, Straube A (2006) TMS motor cortical brain mapping in patients with complex regional pain syndrome type I. Clin Neurophysiol 117:169–176

    PubMed  Google Scholar 

  • Lavie N (2010) Attention, distraction, and cognitive control under load. Curr Dir Psychol Sci 19:143–148

    Google Scholar 

  • Legrain V (2011) Where is my pain? Pain 152:467–468

    PubMed  Google Scholar 

  • Legrain V, Guérit JM, Bruyer R, Plaghki L (2002) Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials. Pain 99:21–39

    PubMed  Google Scholar 

  • Legrain V, Bruyer R, Guérit JM, Plaghki L (2005) Involuntary orientation of attention to unattended deviant nociceptive stimuli is modulated by concomitant visual task difficulty. Evidence from laser evoked potentials. Clin Neurophysiol 116:2165–2174

    PubMed  Google Scholar 

  • Legrain V, Perchet C, Garcia-Larrea L (2009a) Involuntary orienting of attention to pain. Neural and behavioral signatures. J Neurophysiol 102:2423–2434

    PubMed  Google Scholar 

  • Legrain V, Van Damme S, Eccleston C, Davis KD, Seminowicz DA, Crombez G (2009b) A neurocognitive model of attention to pain: behavioral and neuroimaging evidence. Pain 144:230–232

    PubMed  Google Scholar 

  • Legrain V, Iannetti GD, Plaghki L, Mouraux A (2011) The pain matrix reloaded. A salience-detection system for the body. Prog Neurobiol 93:111–124

    PubMed  Google Scholar 

  • Legrain V, Bultitude JH, De Paepe AL, Rossetti Y (2012a) Pain, body, and space. What do patients with complex regional pain syndrome really neglect? Pain 153:948–951

    PubMed  Google Scholar 

  • Legrain V, Mancini F, Sambo CF, Torta DM, Ronga I, Valentini E (2012b) Cognitive aspects of nociception and pain. Bridging neurophysiology with cognitive psychology. Neurophysiol Clin 42:325–336

    CAS  PubMed  Google Scholar 

  • Legrain V, Crombez G, Plaghki L, Mouraux A (2013) Shielding cognition from nociception with working memory. Cortex 49:1922–1934

    PubMed  Google Scholar 

  • Leventhal H, Everhart D (1979) Emotions, pain, and physical illness. In: Izard CE (ed) Emotions in personality and psychopathology. Plenum, New York, pp 263–299

    Google Scholar 

  • Liu CC, Veldhuijzen DS, Ohara S, Winberry J, Greenspan JD, Lenz FA (2011) Spatial attention to thermal pain stimuli in subjects with visual spatial hemi-neglect: extinction, mislocalization and misidentification of stimulus modality. Pain 152:498–506

    PubMed Central  CAS  PubMed  Google Scholar 

  • Longo MR, Betti V, Aglioti SM, Haggard P (2009) Visually induced analgesia: seeing the body reduces pain. J Neurosci 29:12125–12130

    CAS  PubMed  Google Scholar 

  • Macaluso E, Maravita A (2010) The representation of space near the body through touch and vision. Neuropsychologia 48:782–795

    CAS  PubMed  Google Scholar 

  • Maihöfner C, Handwerker HO, Neundörfer B, Birklein F (2004) Cortical reorganization during recovery from complex regional pain syndrome. Neurology 63:693–701

    PubMed  Google Scholar 

  • Maihöfner C, Neundörfer B, Birklein F, Handwerker HO (2006) Mislocalization of tactile stimulation in patients with complex regional pain syndrome. J Neurol 253:772–779

    PubMed  Google Scholar 

  • Maihöfner C, Baron R, DeCol R, Binder A, Birklein F, Deuschl G, Handwerker HO, Schattschneider J (2007) The motor system shows adaptive changes in complex regional pain syndrome. Brain 130:2671–2687

    PubMed  Google Scholar 

  • Mancini F, Longo MR, Kammers MP, Haggard P (2011) Visual distortion of body size modulates pain perception. Psychol Sci 22:325–330

    PubMed  Google Scholar 

  • Maravita A, Spence C, Driver J (2003) Multisensory integration and the body schema: close to hand and within reach. Curr Biol 13:R531–R539

    CAS  PubMed  Google Scholar 

  • Marinus J, Moseley GL, Birklein F, Baron R, Maihöfner C, Kingery WS, van Hilten JJ (2011) Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol 10:637–648

    PubMed  Google Scholar 

  • McCabe CS, Haigh RC, Ring EFJ, Halligan PW, Wall PD, Blake DR (2003) A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1). Rheumatology 42:97–101

    CAS  PubMed  Google Scholar 

  • McCaul KD, Malott JM (1984) Distraction and coping with pain. Psychol Bull 95:516–533

    CAS  PubMed  Google Scholar 

  • Melzack R, Casey KL (1968) Sensory, motivational, and central control determinants of pain: a new conceptual model. In: Kenshalo D (ed) The skin senses. Chas C Thomas, Springfield, pp 423–439

    Google Scholar 

  • Miron D, Duncan GH, Bushnell MC (1989) Effects of attention on the intensity and unpleasantness of thermal pain. Pain 39:345–352

    CAS  PubMed  Google Scholar 

  • Morley S (2011) Efficacy and effectiveness of cognitive behaviour therapy for chronic pain: progress and some challenges. Pain 152:S99–S106

    PubMed  Google Scholar 

  • Moseley GL (2004) Why do people with complex regional pain syndrome take longer to recognize their affected hand? Neurology 64:2182–2186

    Google Scholar 

  • Moseley GL (2005) Distorted body image in complex regional pain syndrome. Neurology 65:773

    PubMed  Google Scholar 

  • Moseley GL, Gallace A, Spence C (2009) Space-based, but not arm-based, shift in tactile processing in complex regional pain syndrome and its relationship to cooling of the affected limb. Brain 132:3142–3151

    PubMed  Google Scholar 

  • Moseley GL, Gallace A, Iannetti GD (2012a) Spatially defined modulation of skin temperature and hand ownership of both hands in patients with unilateral complex regional pain syndrome. Brain 135:3676–3686

    PubMed  Google Scholar 

  • Moseley GL, Gallace A, Spence C (2012b) Bodily illusions in health and disease: physiological and clinical perspectives and the concept of a cortical ‘body matrix’. Neurosci Biobehav Rev 36:34–46

    PubMed  Google Scholar 

  • Moseley GL, Gallace A, Di Pietro F, Spence C, Iannetti GD (2013) Limb-specific autonomic dysfunction in complex regional pain syndrome modulated by wearing prism glasses. Pain 11:2463–2468

    Google Scholar 

  • Näätänen R (1992) Attention and brain function. Erlbaum, Hillsdale

    Google Scholar 

  • Neisser U (1967) Cognitive psychology. Meredith, New York

    Google Scholar 

  • Penfield W, Boldrey E (1937) Somatic and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 60:389–443

    Google Scholar 

  • Peyron R, Garcia-Larrea L, Grégoire MC, Costes N, Convers P, Lavenne F, Mauguière F, Michel D, Laurent B (1999) Haemodynamic brain responses to acute pain in humans. Sensory and attentional networks. Brain 122:1765–1779

    PubMed  Google Scholar 

  • Price DD, Harkins SW (1992) The affective-motivational dimension of pain: a two-stage model. Am Pain Soc J 1:229–239

    Google Scholar 

  • Punt TD, Cooper L, Hey M, Johnson MI (2013) Neglect-like symptoms in complex regional pain syndrome: learned nonuse by another name? Pain 154:200–203

    PubMed  Google Scholar 

  • Ramachandran VS, Rogers-Ramachandran D, Stewart M (1992) Perceptual correlates of massive cortical reorganization. Science 258:1159–1160

    CAS  PubMed  Google Scholar 

  • Reinersmann A, Landwehrt J, Krumova EK, Ocklenburg S, Güntürkün O, Maier C (2012) Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS I). Pain 153:2174–2181

    PubMed  Google Scholar 

  • Rizzolatti G, Craighero L (1998) Spatial attention: mechanisms and theories. In: Sabourin M, Craik F, Robert M (eds) Advances in psychological science, vol 2, Biological and cognitive aspects. Psychology Press, East Sussex, pp 171–198

    Google Scholar 

  • Rizzolatti G, Fadiga L, Fogassi L, Gallese V (1997) The space around us. Science 277:190–191

    CAS  PubMed  Google Scholar 

  • Roa Romero Y, Straube T, Nitsch A, Miltner WHR, Weiss T (2013) Interaction between stimulus intensity and perceptual load in the attentional control of pain. Pain 154:135–140

    Google Scholar 

  • Rode S, Salkovskis PM, Jack T (2001) An experimental study of attention, labelling and memory in people suffering from chronic pain. Pain 94:193–203

    CAS  PubMed  Google Scholar 

  • Rode G, Pisella L, Rossetti Y, Farnès A, Boisson D (2003) Bottom-up transfer of sensory-motor plasticity to recovery of spatial cognition: visuo-motor adaptation and spatial neglect. Prog Brain Res 142:273–287

    PubMed  Google Scholar 

  • Romano D, Maravita A (2014) The visual size of one’s own hand modulates pain anticipation and perception. Neuropsychologia 57:93–100

    PubMed  Google Scholar 

  • Rossetti Y, Rode G, Pisella L, Farnè A, Li L, Boisson D, Perenin MT (1998) Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature 395:166–169

    CAS  PubMed  Google Scholar 

  • Rossetti Y, Jacquin-Courtois S, Legrain V, Bultitude J, O’Shea J (2013) Le syndrome douloureux régional chronique à la lumière des troubles de la cognition spatiale: des opportunités physiopathologiques et thérapeutiques? In: Ribnik P, Genty M (eds) Syndrome douloureux chroniques en médecine physique et de réadaptation. Springer, Paris, pp 99–109

    Google Scholar 

  • Sambo CF, Iannetti GD (2013) Better safe than sorry? The safety margin surrounding the body is increased by anxiety. J Neurosci 33:14225–14230

    CAS  PubMed  Google Scholar 

  • Sambo CF, Forster B, Williams SC, Iannetti GD (2012a) To blink or not to blink: fine cognitive tuning of the defensive peripersonal space. J Neurosci 32:12921–12927

    CAS  PubMed  Google Scholar 

  • Sambo CF, Liang M, Cruccu G, Iannetti GD (2012b) Defensive peripersonal space: the blink reflex evoked by hand stimulation is increased when the hand is near the face. J Neurophysiol 107:880–889

    CAS  PubMed  Google Scholar 

  • Sambo CF, Torta DM, Gallace A, Liang M, Moseley GL, Iannetti GD (2013) The temporal order judgement of tactile and nociceptive stimuli is impaired by crossing the hands over the body midline. Pain 154:242–247

    CAS  PubMed  Google Scholar 

  • Schwoebel J, Friedman R, Duda N, Coslett HB (2001) Pain and the body schema. Evidence for peripheral effects on mental representations of movement. Brain 124:2098–2104

    CAS  PubMed  Google Scholar 

  • Seron X (1994) La neuropsychologie cognitive, 2nd edn. Presses Universitaires de France, Paris

    Google Scholar 

  • Shiffrin RM, Schneider W (1977) Controlled and automatic human information processing. II. Perceptual learning, automatic attending and a general theory. Psychol Rev 84:127–190

    Google Scholar 

  • Shore DI, Spry E, Spence C (2002) Confusing the mind by crossing the hands. Cogn Brain Res 14:153–163

    Google Scholar 

  • Smania N, Aglioti S (1995) Sensory and spatial components of somaesthetic deficits following right brain damage. Neurology 45:1725–1730

    CAS  PubMed  Google Scholar 

  • Spence C, Pavani F, Driver J (2004) Spatial constraints on visual-tactile cross-modal distractor congruency effects. Cogn Affect Behav Neurosci 4:148–169

    PubMed  Google Scholar 

  • Sumitani M, Rossetti Y, Shibata M, Matsuda Y, Sakaue G, Inoue T, Mashimo T, Miyauchi S (2007a) Prism adaptation to optical deviation alleviates pathologic pain. Neurology 68:128–133

    CAS  PubMed  Google Scholar 

  • Sumitani M, Shibata M, Iwakura T, Matsuda Y, Sakaue G, Inoue T, Mashimo T, Miyauchi S (2007b) Pathologic pain distorts visuospatial perception. Neurology 68:152–154

    CAS  PubMed  Google Scholar 

  • Torta DM, Diano M, Costa T, Gallace A, Duca S, Geminiani GC, Cauda F (2013) Crossing the line of pain: fMRI correlates of crossed-hands analgesia. J Pain 14:957–965

    PubMed  Google Scholar 

  • Vallar G, Maravita A (2009) Personal and extrapersonal spatial perception. In: Berntson GG, Cacioppo JT (eds) Handbook of neuroscience for the behavioral sciences. Wiley, New York, pp 322–336

    Google Scholar 

  • Van Damme S, Legrain V, Vogt J, Crombez G (2010) Keeping pain in mind: a motivational perspective on attentional processing of pain. Neurosci Biobehav Rev 34:204–213

    PubMed  Google Scholar 

  • Van Ryckeghem DML, Van Damme S, Crombez G, Eccleston C, Verhoeven K, Legrain V (2011) The role of spatial attention in attentional control over pain: an experimental investigation. Exp Brain Res 208:269–275

    PubMed  Google Scholar 

  • Van Ryckeghem DML, Crombez G, Eccleston C, Legrain V, Van Damme S (2013) Keeping pain out of your mind: the role of attentional set in pain. Eur J Pain 17:402–411

    PubMed  Google Scholar 

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Legrain, V., Torta, D.M. (2015). Cognitive Psychology and Neuropsychology of Nociception and Pain. In: Pickering, G., Gibson, S. (eds) Pain, Emotion and Cognition. Springer, Cham. https://doi.org/10.1007/978-3-319-12033-1_1

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