Abstract
Atypical teratoid/rhabdoid tumor (AT/RT) is a distinct tumor of young children based on morphological, immunohistochemical, and cytogenetic characteristics. It is included in the World Health Organization classification as grade IV embryonal neoplasm. Sometimes it is difficult to recognize by using only histopathologic criteria. Microscopically, AT/RT contains sheets of rhabdoid cells, primitive neuroectodermal cells, mesenchymal cells, or epithelial cells. The immunohistochemical profile is complex, but the absence of nuclear expression of INI1 has emerged as a critical tool for accurate AT/RT diagnosis.
The differential diagnosis for lesions in the posterior fossa usually focuses on the medulloblastoma. The cytomorphologic differential diagnosis includes medulloblastoma, PNET, choroid plexus carcinoma, metastatic adenocarcinoma, gemistocytic astrocytoma, oligodendroglioma, and non-Hodgkin lymphoma, malignant melanoma, and germinoma.
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Karabağlı, P. (2015). Atypical Teratoid/Rhabdoid Tumor. In: Özek, M., Cinalli, G., Maixner, W., Sainte-Rose, C. (eds) Posterior Fossa Tumors in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-11274-9_41
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DOI: https://doi.org/10.1007/978-3-319-11274-9_41
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