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Voice Prostheses, Microbial Colonization and Biofilm Formation

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Biofilm-based Healthcare-associated Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 830))

Abstract

Total laryngectomy is performed in advanced laryngeal and hypopharyngeal cancer stages and results in reduced quality of life due to the loss of voice and smell, permanent tracheostoma and occasionally dysphagia. Therefore, successful voice rehabilitation is highly beneficial for the patients’ quality of life after surgery. Over the past decades, voice prostheses have evolved to the gold standard in rehabilitation and allow faster and superior voicing results after laryngectomy compared to esophageal speech. Polyspecies biofilm formation has become the limiting factor for device lifetimes and causes prosthesis dysfunction, leakage and in consequence pneumonia, if not replaced immediately. Although major improvements in prosthesis design have been made and scientific insight in the complexity of biofilm evolution and material interaction progresses, the microbial colonization continues to restrict device lifetimes, causing patient discomfort and elevated health costs. However, present scientific findings and advances in technology yield promising future approaches to improve the situation for laryngectomized patients.

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References

  • Bauters TGM, Moerman M, Vermeersch H, Nelis HJ (2002) Colonization of voice prostheses by albicans and non-albicans Candida species. Laryngoscope 112:708–712

    Article  PubMed  Google Scholar 

  • Bertl K, Zatorska B, Leonhard M, Rechenmacher-Strauss J, Roesner I, Schneider-Stickler B (2013) Oral microbial colonization in laryngectomized patients as a possible cofactor of biofilm formation on their voice prostheses. J Clin Periodontol 40:833–840

    Article  PubMed  Google Scholar 

  • Biswas S, Van Dijck P, Datta A (2007) Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev 71:348–376

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Boscolo-Rizzo P, Marchiori C, Gava A, Da Mosto MC (2008) The impact of radiotherapy and GERD on in situ lifetime of indwelling voice prostheses. Eur Arch Otorhinolaryngol 265:791–796

    Article  PubMed  Google Scholar 

  • Bozec A, Poissonnet G, Chamorey E, Demard F, Santini J, Peyrade F, Ortholan C, Benezery K, Thariat J, Sudaka A, Anselme K, Adrey B, Giacchero P, Dassonville O (2009) Results of vocal rehabilitation using tracheoesophageal voice prosthesis after total laryngectomy and their predictive factors. Eur Arch Otorhinolaryngol 267:751–758

    Article  PubMed  Google Scholar 

  • Cocuzza S, Bonfiglio M, Chiaramonte R, Aprile G, Mistretta A, Grosso G, Serra A (2012) Gastroesophageal reflux disease and postlaryngectomy tracheoesophageal fistula. Eur Arch Otorhinolaryngol 269:1483–1488

    Article  PubMed  Google Scholar 

  • de Maddalena H, Pfrang H, Schohe R, Zenner HP (1991) Speech intelligibility and psychosocial adaptation in various voice rehabilitation methods following laryngectomy. Laryngorhinootologie 70:562–567

    Article  PubMed  Google Scholar 

  • Debry C, Dupret-Bories A, Vrana NE, Hemar P, Lavalle P, Schultz P (2014) Laryngeal replacement with an artificial larynx after total laryngectomy: the possibility of restoring larynx functionality in the future. Head Neck. doi:10.1002/hed.23621

  • Delsupehe K, Zink I, Lejaegere M, Delaere P (1998) Prospective randomized comparative study of tracheoesophageal voice prosthesis: Blom-Singer versus Provox. Laryngoscope 108:1561–1565

    Article  CAS  PubMed  Google Scholar 

  • Flemming HC (1998) Relevance of biofilms for the biodeterioration of surfaces of polymeric materials. Polym Degrad Stab 59(1–3):309–315

    Article  CAS  Google Scholar 

  • Garrido CM, Liesa RF, Varela HV, Gálvez MJN (2007) Study of laryngopharyngeal reflux using pH-metering in immediate post-op of laryngectomized patients. Acta Otorrinolaringol Esp 58:284–289

    Article  Google Scholar 

  • Harms K, Post WJ, van de Laan KT, van den Hoogen FJA, Eerenstein SEJ, van der Laan BFAM (2011) A prospective randomized multicenter clinical trial of the Provox2 and Groningen Ultra Low Resistance voice prostheses in the rehabilitation of post-laryngectomy patients: a lifetime and preference study. Oral Oncol 47:895–899

    Article  PubMed  Google Scholar 

  • Hilgers FJM, Ackerstaff AH, Balm AJM, Van Den Brekel MWM, Bing Tan I, Persson J-O (2003) A new problem-solving indwelling voice prosthesis, eliminating the need for frequent Candida- and “Underpressure-” related replacements: Provox ActiValve. Acta Otolaryngol 123:972–979

    Article  PubMed  Google Scholar 

  • Hotz MA, Baumann A, Schaller I, Zbären P (2002) Success and predictability of provox prosthesis voice rehabilitation. Arch Otolaryngol Head Neck Surg 128:687–691

    Article  PubMed  Google Scholar 

  • Kania R, Lamers G, Van De Laar N, Dijkhuizen M, Lagendijk E, Tran Ba Huy P, Herman P, Hiemstra P, Grote J, Frijns J, Bloemberg G (2010) Biofilms on tracheoesophageal voice prostheses: a confocal laser scanning microscopy demonstration of mixed bacterial and yeast biofilms. GBIF 26:519–526

    Article  CAS  Google Scholar 

  • Kress P, Schäfer P, Schwerdtfeger F-P (2006) Clinical use of a voice prosthesis with a flap valve containing silver oxide (Blom-Singer Advantage), biofilm formation, in-situ lifetime and indication. Laryngorhinootologie 85:893–896

    Article  CAS  PubMed  Google Scholar 

  • Kress P, Schäfer P, Schwerdtfeger F-P, Rösler S (2013) Are modern voice prostheses better? A lifetime comparison of 749 voice prostheses. Eur Arch Otorhinolaryngol 271(1):133–140. doi:10.1007/s00405-013-2611-0

    Article  PubMed Central  PubMed  Google Scholar 

  • Lam PK-Y, Ho W-K, Ho AC-W, Ng RW-M, Yuen APW, Wei WI (2005) Long-term performance of indwelling tracheoesophageal speaking valves in Chinese patients undergoing laryngectomy. Arch Otolaryngol Head Neck Surg 131:954–958

    Article  PubMed  Google Scholar 

  • Leonhard M, ReumĂĽller A, Moser D, Bigenzahn W, Schneider-Stickler B (2009) Examination of biofilm related material deterioration on 20 PROVOX2 voice prostheses by scanning electron microscopy. Laryngorhinootologie 88:392–397

    Article  CAS  PubMed  Google Scholar 

  • Leonhard M, Moser D, Reumueller A, Mancusi G, Bigenzahn W, Schneider-Stickler B (2010) Comparison of biofilm formation on new Phonax and Provox 2 voice prostheses – a pilot study. Head Neck 32(7):886–895. doi:10.1002/hed.21276

    PubMed  Google Scholar 

  • Lorenz KJ, Maier H (2010) Voice rehabilitation after laryngectomy. HNO 58:1174–1183

    Article  CAS  PubMed  Google Scholar 

  • Lorenz KJ, Grieser L, Ehrhart T, Maier H (2010) The management of periprosthetic leakage in the presence of supra-oesophageal reflux after prosthetic voice rehabilitation. Eur Arch Otorhinolaryngol 268:695–702

    Article  PubMed  Google Scholar 

  • Maves MD, Lingeman RE (1982) Primary vocal rehabilitation using the Blom-Singer and Panje voice prostheses. Ann Otol Rhinol Laryngol 91:458–460

    Article  CAS  PubMed  Google Scholar 

  • Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4:119–128

    Article  PubMed Central  PubMed  Google Scholar 

  • Moukarbel RV, Doyle PC, Yoo JH, Franklin JH, Day AMB, Fung K (2011) Voice-related quality of life (V-RQOL) outcomes in laryngectomees. Head Neck 33:31–36

    Article  PubMed  Google Scholar 

  • Mozolewski E (1972) Surgical rehabilitation of voice and speech following laryngectomy. Otolaryngol Pol 26:653–661

    CAS  PubMed  Google Scholar 

  • Naglik JR, Challacombe SJ, Hube B (2003) Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 67:400–428, table of contents

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Op de Coul BM, Hilgers FJ, Balm AJ, Tan IB, Van Den Hoogen FJ, van Tinteren H (2000) A decade of postlaryngectomy vocal rehabilitation in 318 patients: a single Institution’s experience with consistent application of provox indwelling voice prostheses. Arch Otolaryngol Head Neck Surg 126:1320–1328

    Article  Google Scholar 

  • Panacek A, Kolar M, Vecerova R, Prucek R, Soukupova J, Krystof V, Hamal P, Zboril R, KvItek L (2009) Antifungal activity of silver nanoparticles against Candida spp. Biomaterials 30:6333–6340

    Article  CAS  PubMed  Google Scholar 

  • Pattani KM, Morgan M, Nathan C-AO (2009) Reflux as a cause of tracheoesophageal puncture failure. Laryngoscope 119:121–125

    Article  PubMed  Google Scholar 

  • Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20:133–163

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Politano AD, Campbell KT, Rosenberger LH, Sawyer RG (2013) Use of silver in the prevention and treatment of infections: silver review. Surg Infect 14:8–20

    Article  Google Scholar 

  • Ramage G, MartĂ­nez JP, LĂłpez-Ribot JL (2006) Candida biofilms on implanted biomaterials: a clinically significant problem. FEMS Yeast Res 6:979–986

    Article  CAS  PubMed  Google Scholar 

  • Rodrigues L, Banat IM, Teixeira J, Oliveira R (2007) Strategies for the prevention of microbial biofilm formation on silicone rubber voice prostheses. J Biomed Mater Res 81B:358–370

    Article  CAS  Google Scholar 

  • Rolien H (2014) Free MHJBPGJEMHCVDMPRVWMPFWJAMP: biofilm formation on voice prostheses: in vitro influence of probiotics 1–6

    Google Scholar 

  • Ruhnke M (2006) Epidemiology of Candida albicans infections and role of non-Candida-albicans yeasts. Curr Drug Targets 7:495–504

    Article  CAS  PubMed  Google Scholar 

  • Schäfer P, KlĂĽtzke N, Schwerdtfeger F-P (2001) Voice restoration with voice prosthesis after total laryngectomy. Assessment of survival time of 378 Provox-1, Provox-2 and Blom-Singer voice prosthesis. Laryngorhinootologie 80:677–681

    Article  PubMed  Google Scholar 

  • Schouwenburg PF, Eerenstein SE, Grolman W (1998) The VoiceMaster voice prosthesis for the laryngectomized patient. Clin Otolaryngol Allied Sci 23:555–559

    Article  CAS  PubMed  Google Scholar 

  • Schuldt T, Kramp B, Dommerich S (2012) The vocal rehabilitation with ESKA-Herrmann voice prosthesis. A report of a 10 years’ experience. Laryngorhinootologie 91:633–636

    CAS  PubMed  Google Scholar 

  • Simpson CB, Postma GN, Stone RE, Ossoff RH (1997) Speech outcomes after laryngeal cancer management. Otolaryngol Clin N Am 30:189–205

    CAS  Google Scholar 

  • Singh AV, Vyas V, Patil R, Sharma V, Scopelliti PE et al (2011) Quantitative characterization of the influence of the nanoscale morphology of nanostructured surfaces on bacterial adhesion and biofilm formation. PLoS One 6(9):e25029. doi:10.1371/journal.pone.0025029

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Smit CF, Tan J, Mathus-Vliegen LM, Devriese PP, Brandsen M, Grolman W, Schouwenburg PF (1998) High incidence of gastropharyngeal and gastroesophageal reflux after total laryngectomy. Head Neck 20:619–622

    Article  CAS  PubMed  Google Scholar 

  • Soolsma J, Van Den Brekel MW, Ackerstaff AH, Balm AJ, Tan B, Hilgers FJ (2008) Long-term results of Provox ActiValve, solving the problem of frequent Candida- and “Underpressure-” related voice prosthesis replacements. Laryngoscope 118:252–257

    Article  PubMed  Google Scholar 

  • Terada T, Saeki N, Toh K, Uwa N, Sagawa K, Takayasu S, Sakagami M (2007) Voice rehabilitation with Provox2 voice prosthesis following total laryngectomy for laryngeal and hypopharyngeal carcinoma. Auris Nasus Larynx 34:65–71

    Article  PubMed  Google Scholar 

  • Tićac B, Tićac R, Rukavina T, Kesovija PG, Pedisić D, Maljevac B, StarÄŤević R (2010) Microbial colonization of tracheoesophageal voice prostheses (Provox2) following total laryngectomy. Eur Arch Otorhinolaryngol 267:1579–1586

    Article  PubMed  Google Scholar 

  • Tisch M, Lorenz KJ, St Rrle E, Maier H (2003) Lebensqualität laryngektomierter Patienten nach chirurgischer Stimmrehabilitation. HNO 51:467–472

    Article  CAS  PubMed  Google Scholar 

  • Traissac L, Chene G, Devars F, Houliat T, Essalki I, Bekhar H, Rousseau A (2007) Voice rehabilitation after total laryngectomy using the Newvox voice prosthesis. Rev Laryngol Otol Rhinol (Bord) 128:163–172

    CAS  Google Scholar 

  • Van Den Hoogen FJ, Nijdam HF, Veenstra A, Manni JJ (1996) The Nijdam voice prosthesis: a self-retaining valveless voice prosthesis for vocal rehabilitation after total laryngectomy. Acta Otolaryngol 116(6):913–917

    Article  PubMed  Google Scholar 

  • van der Mei HC, Free RH, Elving GJ, Van Weissenbruch R, Albers FW, Busscher HJ (2000) Effect of probiotic bacteria on prevalence of yeasts in oropharyngeal biofilms on silicone rubber voice prostheses in vitro. J Med Microbiol 49:713–718

    PubMed  Google Scholar 

  • Van Weissenbruch R, Albers FWJ, Bouckaert S, Nelis HJ, Criel G, Remon JP, Sulter AM (1997) Deterioration of the Provox™ silicone tracheoesophageal voice prosthesis: microbial aspects and structural changes. Acta Otolaryngol 117:452–458

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology and Head and Neck Surgery, Medical University Hospital Vienna, Vienna, Austria

    Matthias Leonhard & Berit Schneider-Stickler

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  1. Matthias Leonhard
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  2. Berit Schneider-Stickler
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Correspondence to Berit Schneider-Stickler .

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Editors and Affiliations

  1. Microbial Biofilm Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy

    Gianfranco Donelli

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Leonhard, M., Schneider-Stickler, B. (2015). Voice Prostheses, Microbial Colonization and Biofilm Formation. In: Donelli, G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 830. Springer, Cham. https://doi.org/10.1007/978-3-319-11038-7_8

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