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Modeling of Testosterone Regulation by Pulse-Modulated Feedback

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Signal and Image Analysis for Biomedical and Life Sciences

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 823))

Abstract

The continuous part of a hybrid (pulse-modulated) model of testosterone (Te) feedback regulation in the human male is extended with infinite-dimensional and nonlinear blocks, to obtain the dynamics that better agree with the hormone concentration profiles observed in clinical data. A linear least-squares based optimization algorithm is developed for the purpose of detecting impulses of gonadotropin-releasing hormone (GnRH) from measured concentration of luteinizing hormone (LH). The estimated impulse parameters are instrumental in evaluating the frequency and amplitude modulation functions parameterizing the pulse-modulated feedback. The proposed approach allows for the identification of all model parameters from the hormone concentrations of Te and LH. Simulation results of the complete estimated closed-loop system exhibiting similar to the clinical data behavior are provided.

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Acknowledgements

This work was in part financed by the European Research Council, Advanced Grant 247035 (SysTEAM) and Grant 2012-3153 from the Swedish Research Council.

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Authors and Affiliations

  1. Department of Information Technology, Uppsala University, Box 337, SE-751 05, Uppsala, Sweden

    Per Mattsson & Alexander Medvedev

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  1. Per Mattsson
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  2. Alexander Medvedev
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Correspondence to Per Mattsson .

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Editors and Affiliations

  1. Digital Productivity Flagship, CSIRO, Sydney, New South Wales, Australia

    Changming Sun

  2. Digital Productivity Flagship, CSIRO, Sydney, New South Wales, Australia

    Tomasz Bednarz

  3. The University of Aizu, Fukushima, Japan

    Tuan D. Pham

  4. Digital Productivity Flagship, CSIRO, Sydney, New South Wales, Australia

    Pascal Vallotton

  5. Digital Productivity Flagship, CSIRO, Sydney, New South Wales, Australia

    Dadong Wang

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Mattsson, P., Medvedev, A. (2015). Modeling of Testosterone Regulation by Pulse-Modulated Feedback. In: Sun, C., Bednarz, T., Pham, T., Vallotton, P., Wang, D. (eds) Signal and Image Analysis for Biomedical and Life Sciences. Advances in Experimental Medicine and Biology, vol 823. Springer, Cham. https://doi.org/10.1007/978-3-319-10984-8_2

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