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Venous Thromboembolic Disease

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Abstract

Venous thromboembolism (VTE) is a known possible complication of surgical procedures. In early studies, the incidence of fatal pulmonary embolism, in the absence of prophylaxis, was estimated to be 0.1–0.8 % in patients undergoing elective general surgery, 2–3 % in patients having elective total hip replacement, and 4–7 % of patients undergoing surgery for a fractured hip. The risk for VTE in surgical patients is determined by the combination of patient-related predisposing factors (discussed below) and the specific type of surgery (time length of immobilization, degree of invasiveness, time of postoperative hospitalization). Evidence-based guidelines have been published for VTE prevention as well as for management of patients currently receiving anticoagulation for prior deep vein thrombosis (DVT) or pulmonary embolism (PE) in the perioperative period. The risk of new or recurrent VTE versus the risk of perioperative bleeding while on anticoagulation should be discussed with the surgeon so that a multidisciplinary decision can be made about perioperative anticoagulation management.

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References

  1. Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG. Prevention of venous thromboembolism: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest. 2004;126(3 Suppl):338S.

    Article  CAS  PubMed  Google Scholar 

  2. Pai M, et al. Prevention of venous thromboembolic disease in surgical patients. UptoDate. Article revision date 3/2014. Accessed Mar 2014.

    Google Scholar 

  3. Kearon C, Kahn SR, Agnelli G, et al. Antithrombotic therapy for venous thromboembolic disease. Chest. 2008;133:454–545.

    Article  Google Scholar 

  4. Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S, et al. Prevention of VTE in orthopedic surgery patients. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e278S–325.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e227S–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lip G. Management of anticoagulation before and after elective surgery. UptoDate. Article revision date 10/2013. Accessed Jan 2014.

    Google Scholar 

  7. Kearon C, Hirsh J. Management of anticoagulation before and after elective surgery. N Engl J Med. 1997;336:1506–11.

    Article  CAS  PubMed  Google Scholar 

  8. University of Washington Department of Pharmacy Anticoagulation Services. www.uwmcacc.org. Last update Nov 2013. Accessed Jan 2014.

  9. Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, et al. Perioperative management of antithrombotic therapy. Chest. 2012;141(2 Suppl):e326S–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Geerts WH, et al. http://www.tigc.org/clinical-guides/Inferior-Vena-Cava-Filters.aspx. Accessed May 2011, Jan 2014.

  11. Fedullo P, et al. Placement of inferior vena cava filters and their complications. UptoDate. Article revision date Oct 2013. Accessed Jan 2014.

    Google Scholar 

  12. Imberti D, Biachi M, Farina A, et al. Clinical experience with retrievable vena cava filters: results of a prospective observational multicenter study. J Thromb Haemost. 2005;3:1370–5.

    Article  CAS  PubMed  Google Scholar 

  13. Mismetti P, Rivron-Guillot K, Quenet S, et al. A prospective long-term study of 220 patients with a retrievable vena cava filter for secondary prevention of venous thromboembolism. Chest. 2007;131:223–9.

    Article  PubMed  Google Scholar 

  14. American Academy of Orthopaedic Surgeons—Medical Specialty Society. 2007 May. American Academy of Orthopaedic Surgeons clinical guideline on prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. http://www.ngc.gov/content.aspx?id = 10850. Accessed Dec 2011.

  15. Stewart D, Freshour J. Aspirin for the prophylaxis of venous thromboembolic events in orthopedic surgery patients: a comparison of the AAOS and ACCP guidelines with review of the evidence. Ann Pharmacother. 2013;47(1):63–74.

    Article  PubMed  Google Scholar 

  16. US Food and Drug administration Drug Database. FDA/Center for Drug Evaluation and Research. Office of Communications, Division of Online Communications. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Search_Drug_Name. Update frequency: Daily. Accessed Jan 2014.

  17. Galanis T, Thomson L, Palladino M, et al. New oral anticoagulants. J Thromb Thrombolysis. 2011;31(3):310–20.

    Article  CAS  PubMed  Google Scholar 

  18. Jaff MR, McMurtry S, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011;123:1788–830.

    Article  PubMed  Google Scholar 

  19. Kearon C, Aki EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, et al. Antithrombotic therapy for VTE disease. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e419S–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Erkens PM, Prins MH. Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD001100.

    Google Scholar 

  21. Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349:146–5.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Elizabeth Kaplan M.D. .

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Kaplan, E. (2015). Venous Thromboembolic Disease. In: Jackson, M.B., Mookherjee, S., Hamlin, N.P. (eds) The Perioperative Medicine Consult Handbook. Springer, Cham. https://doi.org/10.1007/978-3-319-09366-6_31

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  • DOI: https://doi.org/10.1007/978-3-319-09366-6_31

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