Skip to main content

Surgical Therapy: Dexamethasone Biodegradable Intravitreal Implant (Ozurdex®)

  • Chapter
  • First Online:
Uveitis

Abstract

The treatment of uveitis has always been a delicate balancing act of managing complications of the disease and the toxicity of the ensuing therapy. Systemic medications have potential side effects to various organ systems in the body and the inherent risk of infectious complications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Martin DF, Parks DJ, Mellow SD, et al. Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant. A randomized controlled clinical trial. Arch Ophthalmol. 1994;112(12):1531–9.

    Article  CAS  PubMed  Google Scholar 

  2. Musch DC, Martin DF, Gordon JF, Davis MD, Kuppermann BD. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. The Ganciclovir Implant Study Group. N Engl J Med. 1997;337(2):83–90.

    Article  CAS  PubMed  Google Scholar 

  3. Sanborn GE, Anand R, Torti RE, et al. Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device. Arch Ophthalmol. 1992;110(2):188–95.

    Article  CAS  PubMed  Google Scholar 

  4. Callanan DG, Jaffe GJ, Martin DF, Pearson PA, Comstock TL. Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial results. Arch Ophthalmol. 2008;126(9):1191–201.

    Article  PubMed  Google Scholar 

  5. Goldstein DA, Godfrey DG, Hall A, et al. Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol. 2007;125(11):1478–85.

    Article  CAS  PubMed  Google Scholar 

  6. Jaffe GJ, Martin D, Callanan D, Pearson PA, Levy B, Comstock T. Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study. Ophthalmology. 2006;113(6):1020–7.

    Article  PubMed  Google Scholar 

  7. Williams GA, Haller JA, Kuppermann BD, et al. Dexamethasone posterior-segment drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome. Am J Ophthalmol. 2009;147(6):1048–54, 1054.e1.

    Google Scholar 

  8. Bratton ML, He YG, Weakley DR. Dexamethasone intravitreal implant (Ozurdex) for the treatment of pediatric uveitis. J AAPOS. 2014;18(2):110–3.

    Article  PubMed  Google Scholar 

  9. Cordero-Coma M, Garzo I, Calleja S, Galan E, Franco M, Ruiz de Morales JG. Preoperative cataract surgery use of an intravitreal dexamethasone implant (Ozurdex) in a patient with juvenile idiopathic arthritis and chronic anterior uveitis. J AAPOS. 2013;17(6):632–4.

    Article  PubMed  Google Scholar 

  10. Kumari N, Parchand S, Kaushik S, Singh R. Intractable glaucoma necessitating dexamethasone implant (Ozurdex) removal and glaucoma surgery in a child with uveitis. BMJ Case Rep. 2013;2013.

    Google Scholar 

  11. Cao JH, Mulvalhill M, Zhang L, Joondeph BC, Dacey MS. Dexamethasone Intravitreal Implant in the treatment of persistent uveitic macular edema in the absence of active inflammation. Ophthalmology 2014.

    Google Scholar 

  12. Tomkins-Netzer O, Taylor SR, Bar A, et al. Treatment with repeat dexamethasone implants results in long-term disease control in eyes with noninfectious uveitis. Ophthalmology 2014.

    Google Scholar 

  13. Malcles A, Janin-Manificat H, Yhuel Y, et al. Anterior chamber migration of intravitreal dexamethasone implant (Ozurdex(R)) in pseudophakic eyes: report of three cases. J Fr Ophtalmol. 2013;36(4):362–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert Wang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Wang, R. (2017). Surgical Therapy: Dexamethasone Biodegradable Intravitreal Implant (Ozurdex®). In: Papaliodis, G. (eds) Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-09126-6_46

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-09126-6_46

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09125-9

  • Online ISBN: 978-3-319-09126-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics