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Adamantiades-Behçet’s Disease

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Uveitis

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Abstract

Adamantiades-Behçet’s Disease (ABD) is a vasculitis that affects multiple organ systems with relapsing chronic symptoms. Classic systemic findings include oral and genital ulcers as well as skin lesions. Ocular findings include anterior and posterior uveitis with vision-threatening complications such as macular edema and optic atrophy. The disease is strongly associated with Human Leukocyte Antigen (HLA)-B51 and predominantly found among people from the Mediterranean basin extending east. The etiology is unknown. Evidence indicates both genetic and environmental factors contribute to the pathogenesis. ABD is treated with steroids and immunomodulatory therapy including biologic agents.

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References

  1. Khairallah M, Accorinti M, Muccioli C, Kahloun R, Kempen J. Epidemiology of Behcet disease. Ocular Immunol Inflamm. 2012;20(5):324–35.

    Article  CAS  Google Scholar 

  2. Piga M, Mathieu A. Genetic susceptibility to Behcet’s disease: role of genes belonging to the MHC region. Rheumatology. 2011;50:299–310.

    Article  CAS  PubMed  Google Scholar 

  3. Tugal-Tutkun I. Imaging in the diagnosis and management of Behcet disease. Int Ophthalmol Clin. 2012;52(4):183–90.

    Article  PubMed  Google Scholar 

  4. Hazirolan D, Sungur G, Duman S. Demographic, clinical and ocular features in patients with late-onset Behcet disease. Ocular Immunol Inflamm. 2012;20(2):119–24.

    Article  Google Scholar 

  5. Emmi G, Silvestri E, Squatrito D, et al. Behcet’s syndrome pathophysiology and potential therapeutic targets. Intern Emerg Med. 2014;9:257–65.

    Article  PubMed  Google Scholar 

  6. Kaneko F, Togashi A, Saito S, et al. Behcet’s disease (Adamantiades-Behcet’s disease). Clin Dev Immunol. 2011;. doi:10.1155/2011/681956.

    PubMed  Google Scholar 

  7. Suzuki Kurokawa M, Suzuki N. Behcet’s disease. Clin Exp Med. 2004;3:10–20.

    Google Scholar 

  8. Chajek T, Fainaru M. Behcet’s disease: report of 41 cases and a review of the literature. Medicine. 1975;54:179.

    Article  CAS  PubMed  Google Scholar 

  9. Wakefield D, Cunningham E, Tugal-Tutkun I, Khairallah M, Ohno S, Zierhut M. Controversies in Behcet disease. Ocular Immunol Inflamm. 2012;21(1):6–11.

    Article  Google Scholar 

  10. Lee S, Bang D, Lee E, Sohn S. Behcet’s diseases: a guide to its clinical understanding. Germany: Springer-Verlag, Berlin Heidelberg; 2001.

    Google Scholar 

  11. Mat C, Yurdakul S, Sevim A, Ozyazgan Y, Tuzun Y. Behcet’s syndrome: facts and controversies. Clin Dermatol. 2013;31:352–61.

    Article  PubMed  Google Scholar 

  12. Balansard B, Bodaghi B, Cassoux N, et al. Necrotising retinopathies simulating acute retinal necrosis syndrome. Br J Ophthalmol. 2005;89(1):96–101.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hatemi G, Silman A, Band D, et al. EULAR recommendations for the management of Behcet disease. Ann Rheum Dis. 2008;67:1656–62.

    Article  CAS  PubMed  Google Scholar 

  14. Deuter CM, Zierhut M, Mohle A, Vonthein R, Stobiger N, Kotter I. Long-term remission after cessation of interferon-alpha treatment in patients with severe uveitis due to Behcet’s disease. Arthritis Rheum. 2010;62(9):2796–805.

    Article  CAS  PubMed  Google Scholar 

  15. Benitah N, Sobrin L, Papaliodis G. The use of biologic agents in the treatment of ocular manifestations of Behcet’s disease. Semin Ophthalmol. 2011;26(4–5):295–303.

    Article  PubMed  Google Scholar 

  16. Levy-Clarke G, Jabs D, Read R, et al. Expert panel recommendations for the use of anti-tumor necrosis factor biologic agents in patients with ocular inflammatory disorders. Ophthalmology. 2014;121:785–96.

    Article  PubMed  Google Scholar 

  17. Keino H, Okada AA, Watanabe T, Taki W. Decreased ocular inflammatory attacks and background retinal and disc vascular leakage in patients with Behcet’s disease on infliximab therapy. Br J Ophthalmol. 2011;95(9):1245–50.

    Article  PubMed  Google Scholar 

  18. Mushtaq B, Saeed T, Situnayake RD, Murray PI. Adalimumab for sight-threatening uveitis in Behcet’s disease. Eye. 2007;21(6):824–5.

    Article  CAS  PubMed  Google Scholar 

  19. Davatchi F, Shams H, Rezaipoor M, et al. Rituximab in intractable ocular lesions of Behcet’s disease; randomized single-blind control study (pilot study). Int J Rheum Dis. 2010;13(3):246–52.

    Article  PubMed  Google Scholar 

  20. Takeuchi M, Asukata Y, Kawagoe T, Ito N, Nishide T, Mizuki N. Infliximab monotherapy versus infliximab and colchicine combination therapy in patients with Behcet’s disease. Ocular Immunol Inflamm. 2012;20(3):193–7.

    Article  CAS  Google Scholar 

  21. Kitaichi N, Miyazaki A, Stanford M, Chames H, Iwata D, Ohno S. Ocular features of Behcet’s disease: an international collaborative study. Br J Ophthalmol. 2007;91:1579–82.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Tabbara K, Al-Hemidan A. Infliximab effects compared to conventional therapy in the management of retinal vasculitis in Behcet’s disease. Am J Ophthalmol. 2008;146:845–50.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Opthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA

    Alice Lorch & Lucia Sobrin

Authors
  1. Alice Lorch
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  2. Lucia Sobrin
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Corresponding author

Correspondence to Alice Lorch .

Editor information

Editors and Affiliations

  1. Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    George N. Papaliodis

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Lorch, A., Sobrin, L. (2017). Adamantiades-Behçet’s Disease. In: Papaliodis, G. (eds) Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-09126-6_17

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  • DOI: https://doi.org/10.1007/978-3-319-09126-6_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09125-9

  • Online ISBN: 978-3-319-09126-6

  • eBook Packages: MedicineMedicine (R0)

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