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Muse Cells

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Cell Engineering and Regeneration

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

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Abstract

Multilineage-differentiating stress-enduring (Muse) cells were first reported in 2010. Since then, multiple groups have elucidated their unique properties. Muse cells are non-tumorigenic endogenous pluripotent-like stem cells that express pluripotency genes; are able to differentiate into triploblastic cells from a single cell and to self-renew; can be isolated as cells positive for a pluripotent stem cell surface marker, stage-specific embryonic antigen-3, from the connective tissue of various organs, as well as the bone marrow and peripheral blood; preferentially migrate to damaged tissue after systemic administration; and spontaneously differentiate into tissue-compatible cells after homing, which enables them to deliver structural and functional recovery with few safety concerns. These properties of Muse cells enable therapeutic effects in only a few simple steps, namely, collection from easily accessible tissue sources, expansion, and administration by intravenous injection. Because Muse cells are naturally existing stem cells with unique reparative functions, they may furnish a novel therapeutic concept compatible with the body’s natural repair system, “reparative medicine,” that does not rely on introducing or manipulating artificial genes.

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Author information

Authors and Affiliations

  1. Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Mari Dezawa

Authors
  1. Mari Dezawa
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Correspondence to Mari Dezawa .

Editor information

Editors and Affiliations

  1. Tulane Univ. Sch. of Medicine, New Orleans, LA, USA

    Jeffrey M. Gimble

  2. AUVA Trauma Research Center, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

    Darja Marolt Presen

  3. Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, UK

    Richard O. C. Oreffo

  4. AUVA Trauma Research Center, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

    Susanne Wolbank

  5. AUVA Trauma Research Center, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

    Heinz Redl

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© 2020 Springer Nature Switzerland AG

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Dezawa, M. (2020). Muse Cells. In: Gimble, J., Marolt Presen, D., Oreffo, R., Wolbank, S., Redl, H. (eds) Cell Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-08831-0_63

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