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Stress, Kindling and PTSD: Typical Symptoms of Temporal Lobe Epilepsy and Antiepileptic Medication

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Comprehensive Guide to Post-Traumatic Stress Disorders

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Abstract

According to recent reported findings, stress experiences are related to neurobiological processes that may have lasting consequences and significantly influence brain functions. These stress experiences may lead to cognitive and emotional dysregulation related to deficits in inhibitory functions and increased limbic excitability that may cause temporo-limbic seizure-like activity and specific changes in neural dynamics and complexity of neural networks. These findings indicate that stress-activated limbic kindling may be involved in the pathogenesis of post-traumatic stress disorder and some other psychiatric disorders which may explain the efficacy of antiepileptic drugs.

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Acknowledgements

The study was supported by the grant GACR P407/12/1957 and the project “CEITEC – Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from European Regional Development Fund.

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Authors and Affiliations

  1. Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, Charles University, First Faculty of Medicine, Ke Karlovu 11, 128 00, Prague, Czech Republic

    Petr Bob

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  1. Petr Bob
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Correspondence to Petr Bob .

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Editors and Affiliations

  1. Faculty of Society and Health, Buckinghamshire New University, Uxbridge, Middlesex, United Kingdom

    Colin R. Martin

  2. FactyofLifeSci&Med,Diabts&NutrnSciRshDiv, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. DepartofBiomedicalSci,SchoolofLifeScienc, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Bob, P. (2016). Stress, Kindling and PTSD: Typical Symptoms of Temporal Lobe Epilepsy and Antiepileptic Medication. In: Martin, C., Preedy, V., Patel, V. (eds) Comprehensive Guide to Post-Traumatic Stress Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-08359-9_94

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