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Targeted Liposomes and Micelles as Carriers for Cancer Therapy

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Nano-Oncologicals

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Targeted self-assembly drug delivery systems, including liposomes and micelles, have been developed for cancer therapy to improve therapeutic effects and to minimize potential drug toxicity. A variety of targeting strategies, such as active targeting, tumor microenvironment responsive targeting and triggered targeting, have given crucial pulses to the design and development of novel drug delivery systems for cancer therapy.

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Abbreviations

9-NC:

9-Nitro-camptothecin

CMC:

Critical micellar concentration

CPT:

Camptothecin

DHPC:

Diheptanolyphosphatidylcholine

DPPC:

1,2-Dipalmitoyl-sn-glycero-2-phosphocholine

DPPGOG:

1,2-Dipalmitoyl-sn-glycero-3-phosphoglyceroglycerol

ECM:

Extracellular matrix

EGFR:

Epidermal growth factor receptors

ELP:

Elastin-like polypeptide

EPR:

Enhanced permeability and retention

FRV:

Freeze-dried rehydration vesicle

LCST:

Low critical solution temperature

MDR:

Multidrug resistance

MLV:

Multilamellar large vesicle

MMPs:

Matrix metalloproteinases

MPS:

Mononuclear phagocyte system

PEG-b-PDLA:

Poly(ethylene glycol)-b-poly(d-lactic acid)

PEG-b-PLLA:

Poly(ethylene glycol)-b-poly(l-lactic acid)

PEG-DSPE:

Poly(ethyl glycol)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine

PEG-PCL:

Poly(ethylene glycol)-b-poly(ε-caprolactone)

PFP:

Perfluoropentane

pHLIP:

Low pH inserting peptide

PIC:

Polyion complex micelle

PNIPPAm:

Poly(N-isopropylacrylamide)

RES:

Reticuloendothelial system

REV:

Reverse-phase evaporation vesicle

sPLA2 :

Secretory phospholipase A2

SUV:

Small unilamellar vesicle

TEM:

Transmission electron microscopy

TfR:

Transferrin receptor

uPA:

Urokinase plasminogen activator

uPAR:

Urokinase plasminogen activator receptor

VEGFR:

Vascular endothelial growth factor receptor

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Author notes

  1. Changyou Zhan

    Present address: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Children’s Hospital Boston, Harvard Medical School, Boston, MA, 02115, USA

Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, 826 Zhangheng Road, Shanghai, 201203, China

    Weiyue Lu & Changyou Zhan

  2. National Pharmaceutical Engineering Research Center, Shanghai Institute of Industrial Pharmaceutics, Shanghai, 201203, China

    Huimin Hou

Authors
  1. Weiyue Lu
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  2. Changyou Zhan
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  3. Huimin Hou
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Corresponding author

Correspondence to Weiyue Lu .

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Editors and Affiliations

  1. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain

    Maria José Alonso

  2. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain

    Marcos Garcia-Fuentes

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Lu, W., Zhan, C., Hou, H. (2014). Targeted Liposomes and Micelles as Carriers for Cancer Therapy. In: Alonso, M., Garcia-Fuentes, M. (eds) Nano-Oncologicals. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-08084-0_4

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