Abstract
Selective electrical stimulation of peripheral nerves has shown potential in reducing symptoms of Phantom Limb Pain (PLP). The cuff electrode design is used in clinical applications, however, it is not able to selectively activate deeper fascicles of large human sized nerves. This work investigates the effects of combining an Interfascicular and a Cuff Electrode (ICE). An ICE was constructed, consisting of an eight contact cuff (two full ring contact sites in each end, six contact sites in a center ring configuration) and an interfascicular wire electrode, which was placed in the center of the nerve. In vitro experiments were conducted on three pig median nerves. During in vitro experiments transversal stimulation was performed using the cuff alone or in combination with the interfascicular electrode. The evoked Compound Action Potentials (eCAP) were recorded from 26-30 individual fascicles and used to quantify the selectivity performance of the different stimulation configurations.
Device selectivity was 0.25 ±0.10 for the ICE and 0.20 ±0.11 for the cuff. This is an improvement of 22.08% ± 13.60% for the ICE over the cuff. The ICE could therefore prove to be a simple and effective improvement over existing cuff electrodes, which could see potential use in treatment of PLP and other areas where selective stimulation is required.
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References
Navarro, X., Vivó, M., Valero-Cabré, A.: Neural plasticity after peripheral nerve injury and regeneration. Progress in Neurobiology 82(4), 163–201 (2007)
Hunter, J.P.: The effect of tactile and visual sensory inputs on phantom limb awareness. Brain 126(3), 579–589 (2003)
Flor, H.: Phantom-limb pain: characteristics, causes, and treatment. Lancet Neurology 1(3), 182–189 (2002)
Flor, H., Denke, C., Schaefer, M., Grüsser, S.: Effect of sensory discrimination training on cortical reorganisation and phantom limb pain. Lancet 357(9270), 1763–1764 (2001)
Huse, E., Preissl, H., Larbig, W., Birbaumer, N.: Phantom limb pain. Lancet 358(9286), 1015 (2001)
Jensen, W., Micera, S., Navarro, X., Stieglitz, T., Guiraud, D., Divoux, J.L., Rossini, P.M., Yoshida, K.: Development of an implantable transverse intrafascicular multichannel electrode (TIME) system for relieving phantom limb pain. In: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. 2010, pp. 6214–6217 (January 2010)
Rossini, P.M., Micera, S., Benvenuto, A., Carpaneto, J., Cavallo, G., Citi, L., Cipriani, C., Denaro, L., Denaro, V., Di Pino, G., Ferreri, F., Guglielmelli, E., Hoffmann, K.-P., Raspopovic, S., Rigosa, J., Rossini, L., Tombini, M., Dario, P.: Double nerve intraneural interface implant on a human amputee for robotic hand control. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 121(5), 777–783 (2010)
Navarro, X., Krueger, T.B., Lago, N., Micera, S., Stieglitz, T., Dario, P.: A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems. Journal of the Peripheral Nervous System: JPNS 10(3), 229–258 (2005)
Grill, W., Mortimer, J.: Stimulus waveforms for selective neural stimulation. IEEE Engineering in Medicine and Biology Magazine 14(4), 375–385 (1995)
Tyler, D.J., Durand, D.M.: Functionally selective peripheral nerve stimulation with a flat interface nerve electrode. IEEE Transactions on Neural Systems and Rehabilitation Engineering: a Publication of the IEEE Engineering in Medicine and Biology Society 10(4), 294–303 (2002)
Riso, R., Dalmose, A., Stefania, D., Schuttler, M.: Addition of an intrafascicular electrode at the site of application of a multipolar nerve cuff enhances the opportunity for selective fascicular activation. In: 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. 1, pp. 711–714. IEEE (2001)
Kundu, A., Harreby, K.R., Jensen, W.: Comparison of median and ulnar nerve morphology of Danish landrace pigs and Göttingen mini pigs. In: Annual Conference of the …, pp. 1–4 (2012)
Haugland, M.: A flexible method for fabrication of nerve cuff electrodes. Engineering in Medicine and Biology Society, …, 359–360 (1996)
Lontis, E.R., Nielsen, K., Struijk, J.J.: In vitro magnetic stimulation of pig phrenic nerve with transverse and longitudinal induced electric fields: analysis of the stimulation site. IEEE Transactions on Bio-medical Engineering 56(2), 500–512 (2009)
Schiefer, M.A., Polasek, K.H., Triolo, R.J., Pinault, G.C.J., Tyler, D.J.: Selective stimulation of the human femoral nerve with a flat interface nerve electrode. Journal of Neural Engineering 7(2), 26006 (2010)
Jensen, W., Harreby, K.R.: Selectivity of Peripheral Neural Interfaces. In: Introduction to Neural Engineering for Motor Rehabilitation, ch. 22 (2013)
Ranck, J.B.: Which elements are excited in electrical stimulation of mammalian central nervous system: A review. Brain Research 98(3), 417–440 (1975)
Bronzino, J.D.: Biomedical Engineering Handbook, 2nd edn. Electrical Engineering Handbook. Taylor & Francis (1999)
Nielsen, T., Sevcencu, C., Struijk, J.: Comparison of Mono-, Bi-, and Tripolar Configurations for Stimulation and Recording With an Interfascicular Interface. IEEE Transactions on Neural Systems and Rehabilitation Engineering: a Publication of the IEEE Engineering in Medicine and Biology Society (August 2013)
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Ranieri, A., Andersen, R.E., Lauridsen, M.V., Harreby, K.R. (2014). A Combined Interfascicular-Cuff Electrode (ICE) for Selective Recruitment of Polyfascicular Peripheral Nerves Using Transversal Stimulation. In: Jensen, W., Andersen, O., Akay, M. (eds) Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation. Biosystems & Biorobotics, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-08072-7_96
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DOI: https://doi.org/10.1007/978-3-319-08072-7_96
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