Abstract
Vagus nerve (VN) stimulation (VNS) is used in epilepsy and tested for blood pressure (BP) control. Whereas the present VNS methods are scheduled, closed-loop VNS (CL-VNS) may be safer and more efficient. However, CL-VNS for epilepsy and BP control require implantable means to monitor seizures and BP changes and such means are not available yet. It is known that the VN conducts afferent BP-related signals, and that seizures are often preceded by BP changes. This study was performed to investigate if such BP-related signals can be recorded using implantable means and if information regarding BP changes can be derived from such recordings. The experiments were performed in two pigs subjected to adrenaline administration for BP increase. The left VN electroneurogram (VENG) was recorded using cuff electrodes, the BP using carotid catheters and the ECG using surface electrodes. By ensemble averaging the VENG activity relative to the R-peaks, afferent BP-related VENG profiles (BP-VENGs) were extracted from the VENG. The BP-VENGs were morphologically similar, proportional and in phase with the carotid BP pulses. The maximum amplitude of those profiles was used to derive a phasic VENG component (pVENG) which changed proportional to the mean BP changes. It is concluded that the BP-VENGs and pVENG could eventually be implemented in CL-VNS for epilepsy and BP control to monitor BP changes and modulate on-demand VNS.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ramani, R.: Vagus nerve stimulation therapy for seizures. J. Neurosurg. Anesthesiol. 20(1), 29–35 (2008)
De Ferrari, G.M., Crijns, H.J., Borggrefe, M., Milasinovic, G., Smid, J., Zabel, M., Gavazzi, A., Sanzo, A., Dennert, R., Kuschyk, J., Raspopovic, S., Klein, H., Swedberg, K., Schwartz, P.J.: Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur. Heart J. 32(7), 847–855 (2011)
Tosato, M., Yoshida, K., Toft, E., Nekrasas, V., Struijk, J.J.: Closed-loop control of the heart rate by electrical stimulation of the vagus nerve. Med. Biol. Eng. Comput. 44(3), 161–169 (2006)
Morris III, G.L.: A retrospective analysis of the effects of magnet-activated stimulation in conjunction with vagus nerve stimulation therapy. Epilepsy. Behav. 4(6), 740–745 (2003)
Tatum, W.O., Moore, D.B., Stecker, M.M., Baltuch, G.H., French, J.A., Ferreira, J.A., Carney, P.M., Labar, D.R., Vale, F.L.: Ventricular asystole during vagus nerve stimulation for epilepsy in humans. Neurology 52(6), 1267–1269 (1999)
Andresen, M.C., Hofmann, M.E., Fawley, J.A.: The unsilent majority-TRPV1 drives “spontaneous” transmission of unmyelinated primary afferents within cardiorespiratory NTS. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(12), R1207–R1216 (2012)
Sevcencu, C., Struijk, J.J.: Autonomic alterations and cardiac changes in epilepsy. Epilepsia 51(5), 725–737 (2010)
Harreby, K.R., Sevcencu, C., Struijk, J.J.: Ictal and peri-ictal changes in cervical vagus nerve activity associated with cardiac effects. Med. Biol. Eng. Comput. 49(9), 1025–1033 (2011)
McAllen, R.M., Spyer, K.M.: The baroreceptor input to cardiac vagal motoneurones. J. Physiol. 282, 365–374 (1978)
Harreby, K.R., Sevcencu, C., Struijk, J.J.: Early seizure detection in rats based on vagus nerve activity. Med. Biol. Eng. Comput. 49(2), 143–151 (2011)
Angell James, J.E.: The effects of altering mean pressure, pulse pressure and pulse frequency on the impulse activity in baroreceptor fibres from the aortic arch and right subclavian artery in the rabbit. J. Physiol. 214(1), 65–88 (1971)
Plachta, D.T.T., Espinosa, N., Gierthmuehlen, M., Cota, O., Herrera, T.C., Stieglitz, T.: Detection of baroreceptor activity in rat vagal nerve recording using a multi-channel cuff-electrode and real-time coherent averaging. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 3416–3419 (2012), doi:10.1109/EMBC.2012.6346699
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this paper
Cite this paper
Sevcencu, C., Nielsen, T.N., Struijk, J.J. (2014). A Blood Pressure-Related Profile Extracted from Pig Left Vagus Nerves Using Cuff Electrodes. In: Jensen, W., Andersen, O., Akay, M. (eds) Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation. Biosystems & Biorobotics, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-08072-7_100
Download citation
DOI: https://doi.org/10.1007/978-3-319-08072-7_100
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08071-0
Online ISBN: 978-3-319-08072-7
eBook Packages: EngineeringEngineering (R0)