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Inflammatory Bowel Diseases

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Colitis

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Abstract

Inflammatory bowel disease (IBD) is a group of chronic idiopathic inflammatory conditions. The two major types are ulcerative colitis (UC) which affects the colon and Crohn’s disease (CD) which can involve the whole gastrointestinal tract but is most common in the terminal ileum and colon. There is a genetic predisposition for IBD, and patients with this condition are more prone to the development of malignancy. Further types to be considered are indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU). These are essentially “temporary diagnoses” when the difference between UC and CD cannot be established definitely at the time of presentation. IC should be used when examination of surgical samples is available together with clinical, serological, and imaging data, while IBDU is used for patients from whom only endoscopic biopsies are available. CD and UC must be considered in the differential diagnosis of clinically acute colitis because of differences in treatment strategies between infections and IBD. The differential diagnosis is particularly important when the complaints are persisting. Histology plays a key role in the diagnosis. Major diagnostic features are architectural distortion and basal plasmacytosis.

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References

  1. Pera A, Bellardo P, Caldera A, et al. Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of endoscopic score. Gastroenterology. 1987;92:181–5.

    CAS  PubMed  Google Scholar 

  2. Broome U, Bergquist A. Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer. Semin Liver Dis. 2006;26:31–41.

    PubMed  Google Scholar 

  3. Loftus Jr EV, Harewood GC, Loftus CG, et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut. 2005;54:91–6.

    PubMed Central  PubMed  Google Scholar 

  4. Joo M, Abreu-E-Lima P, Farraye F, et al. Pathologic features of ulcerative colitis in patients with primary sclerosing cholangitis: a case-control study. Am J Surg Pathol. 2009;33:854–62.

    PubMed  Google Scholar 

  5. Jörgensen KK, Grzyb K, Lundin KEA, et al. Inflammatory bowel disease in patients with primary sclerosing cholangitis: clinical characterization in liver transplanted and nontransplanted patients. Inflamm Bowel Dis. 2012;18:536–45.

    PubMed  Google Scholar 

  6. Wright R, Truelove SR. Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets. Am J Dig Dis. 1966;11:847–57.

    CAS  PubMed  Google Scholar 

  7. Riley SA, Mani V, Goodman MJ, et al. Microscopic activity in ulcerative colitis: what does it mean? Gut. 1991;32:174–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  8. Hefti MM, Chessin DB, Harpaz NH, et al. Severity of inflammation as a predictor of colectomy in patients with chronic ulcerative colitis. Dis Colon Rectum. 2009;52:193–7.

    PubMed Central  PubMed  Google Scholar 

  9. Nostrant TT, Kumar NB, Appelman HD. Histopathology differentiates acute self-limited colitis from ulcerative colitis. Gastroenterology. 1987;92:318–28.

    CAS  PubMed  Google Scholar 

  10. Therkildsen MH, Jensen BN, Stubbe P, Rasmussen TS. The final outcome of patients presenting with their first episode of acute diarrhea and an inflamed mucosa with preserved crypt architecture. A clinicopathologic study. Scand J Gastroenterol. 1989;24:158–64.

    CAS  PubMed  Google Scholar 

  11. Odze R, Antonioli D, Peppercorn M, et al. Effect of topical 5-amino-salicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. Am J Surg Pathol. 1993;17:869–75.

    CAS  PubMed  Google Scholar 

  12. Rubio CA, Johansson C, Uribe A, Kock J. A quantitative method of estimating inflammation in the rectal mucosa. IV. Ulcerative colitis in remission. Scand J Gastroenterol. 1982;17:1077–81.

    CAS  PubMed  Google Scholar 

  13. Geboes K, El-Deeb G, El-Haddad S, Desmet VJ. Challenges in ulcerative colitis; the pathologist’s point of view. Acta Endoscopica. 1994;24:313–26.

    Google Scholar 

  14. Schumacher G, Kollberg B, Sandstedt B. A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation. Scand J Gastroenterol. 1994;29:318–32.

    CAS  PubMed  Google Scholar 

  15. Surawicz C. What’s the best way to differentiate infectious colitis (acute self-limited colitis) from IBD? Inflamm Bowel Dis. 2008;14:s157–8.

    PubMed  Google Scholar 

  16. Sachar DB, Andrews H, Farmer RG, et al. Proposed classification of patient subgroups in Crohn’s disease. Working team report 4. Gastroenterol Int. 1992;3:141–54.

    Google Scholar 

  17. Vasiliauskas EA, Plevy SE, Landers CJ, et al. Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn’s disease define a clinical subgroup. Gastroenterology. 1996;110:1810–9.

    CAS  PubMed  Google Scholar 

  18. Geboes K, Ectors N. Diagnosis of ulcerative colitis in endoscopic biopsies. Hepatogastroenterology. 1989;36:188–92.

    CAS  PubMed  Google Scholar 

  19. Forbes E, et al. Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase. J Immunol. 2004;172:5664–75.

    CAS  PubMed  Google Scholar 

  20. Mir A, et al. Elevated serum eotaxin levels in patients with inflammatory bowel disease. Am J Gastroenterol. 2002;97:1452–7.

    CAS  PubMed  Google Scholar 

  21. Heatley RV, James PD. Eosinophils in the rectal mucosa. A simple method of predicting the outcome of ulcerative proctocolitis? Gut. 1979;20:787–91.

    CAS  PubMed Central  PubMed  Google Scholar 

  22. Bischoff SC, Mayer J, Nguyen QT, et al. Immunohistological assessment of intestinal eosinophil activation in patients with eosinophilic gastroenteritis and inflammatory bowel disease. Am J Gastroenterol. 1999;94:3521–9.

    CAS  PubMed  Google Scholar 

  23. Raab Y, Fredens K, Gerdin B, Hällgren R. Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents. Dig Dis Sci. 1998;43:1061–70.

    CAS  PubMed  Google Scholar 

  24. Bitton A, Peppercorn MA, Antonioli DA, et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology. 2001;120:13–20.

    CAS  PubMed  Google Scholar 

  25. Bessissow T, Lemmens B, Ferrante M, et al. Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing. Am J Gastroenterol. 2012;107:1684–92.

    PubMed  Google Scholar 

  26. Keren DF, Appelman HD, Dobbins 3rd WO, et al. Correlation of histopathologic evidence of disease activity with the presence of immunoglobulin-containing cells in the colons of patients with inflammatory bowel disease. Hum Pathol. 1984;15:757–63.

    CAS  PubMed  Google Scholar 

  27. Truelove SC, Richards WC. Biopsy studies in ulcerative colitis. Br Med J. 1956;1:1315–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  28. Bressenot A, Geboes K, Vignaud JM, et al. Microscopic features for initial diagnosis and disease activity evaluation in inflammatory bowel disease. Inflamm Bow Dis. 2013;19:1745–52.

    Google Scholar 

  29. Kandiel A, Lashner B. Cytomegalovirus colitis complicating inflammatory bowel disease. Am J Gastroenterol. 2006;101:2857–65.

    CAS  PubMed  Google Scholar 

  30. Ayre K, Warren BF, Jeffery K, Travis SP. The role of CMV in steroid-resistant ulcerative colitis: a systematic review. J Crohns Colitis. 2009;3:141–8.

    PubMed  Google Scholar 

  31. Kuwabara A, Okamoto H, Suda T, et al. Clinicopathologic characteristics of clinically relevant cytomegalovirus infection in inflammatory bowel disease. J Gastroenterol. 2007;42:823–9.

    PubMed  Google Scholar 

  32. Markowitz J, Kahn E, Grancher K, et al. Atypical rectosigmoid histology in children with newly diagnosed ulcerative colitis. Am J Gastroenterol. 1993;88:2034–7.

    CAS  PubMed  Google Scholar 

  33. Robert ME, Tang L, Hao M, Reyes-Mugica M. Patterns of inflammation in mucosal biopsies of ulcerative colitis. Perceived differences in pediatric populations are limited to children younger than 10 years. Am J Surg Pathol. 2004;28:183–9.

    CAS  PubMed  Google Scholar 

  34. Washington K, Greenson JK, Montgomery E, et al. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol. 2002;26:1441–9.

    PubMed  Google Scholar 

  35. Geboes K, Van Eyken P. My approach to indeterminate colitis: the role of the pathologist. J Clin Pathol. 2009;62:201–5.

    CAS  PubMed  Google Scholar 

  36. Villanacci V, Antonelli E, Geboes K, et al. Histological healing in inflammatory bowel disease: a still unfulfilled promise. World J Gastroenterol. 2013;19:968–78.

    PubMed Central  PubMed  Google Scholar 

  37. Mosli MH, Feagan B, Sandborn WJ, et al. Histologic evaluation of disease activity in ulcerative colitis: a systematic review of histological disease activity indices. Inflamm Bow Dis. 2014;20:564–575.

    Google Scholar 

  38. Dourmashkin RR, Davies H, Wells C, Shah D, et al. Epithelial patchy necrosis in Crohn’s disease. Hum Pathol. 1983;14:643–8.

    CAS  PubMed  Google Scholar 

  39. Dvorak A, Connell AB, Dickersin GR. Crohn’s disease: a scanning electron microscopic study. Hum Pathol. 1979;10:165–77.

    CAS  PubMed  Google Scholar 

  40. Cuvelier CA, Quatacker J, Mielants H, et al. M cells are damaged and increased in number in inflamed human ileal mucosa. Eur J Morphol. 1993;31:87–91.

    CAS  PubMed  Google Scholar 

  41. Fujimura Y, Hosobe M, Kihara T. Ultrastructural study of M cells from colonic lymphoid nodules obtained by colonoscopic biopsy. Dig Dis Sci. 1992;37:1089–98.

    CAS  PubMed  Google Scholar 

  42. Tanaka M, Riddell RH. The pathological diagnosis and differential diagnosis of Crohn’s disease. Hepatogastroenterology. 1990;37:18–31.

    CAS  PubMed  Google Scholar 

  43. Sankey EA, Dhillon AP, Anthony A, et al. Early mucosal changes in Crohn’s disease. Gut. 1993;34:375–81.

    CAS  PubMed Central  PubMed  Google Scholar 

  44. Sanders DS. Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn’s disease. J Clin Pathol. 2005;58:568–72.

    CAS  PubMed Central  PubMed  Google Scholar 

  45. Maunoury V, Mordon S, Geboes K, et al. Early vascular changes in Crohn’s disease: an endoscopic fluorescence study. Endoscopy. 2000;32:700–5.

    CAS  PubMed  Google Scholar 

  46. Heresbach D, Heresbach-Le Berre N, Ramée MP, et al. Fréquence et valeur pronostique du granulome épithélioïde au cours des maladies inflammatoires chroniques de l’intestin. Gastroenterol Clin Biol. 1999;23:1376–87.

    CAS  PubMed  Google Scholar 

  47. Geboes K, Vantrappen G. The value of colonoscopy in the diagnosis of Crohn’s disease. Gastrointest Endosc. 1975;22:18–23.

    CAS  PubMed  Google Scholar 

  48. Jouret A, Mainguet P. Diagnostic value of systematic endoscopic biopsies in ileocolonic Crohn’s disease. Acta Gastroenterol Belg. 1993;56:C71.

    Google Scholar 

  49. Chambers TJ, Morson BC. The granuloma in Crohn’s disease. Gut. 1979;20:269–74.

    CAS  PubMed Central  PubMed  Google Scholar 

  50. Baert F, Hart J, Blackstone MO. A case of diclofenac-induced colitis with focal granulomatous change. Am J Gastroenterol. 1995;90:1871–3.

    CAS  PubMed  Google Scholar 

  51. Mathew RC, Weinstock JV. Granuloma formation. In: Targan SR, Shanahan F, editors. Inflammatory bowel disease: from bench to bedside. Baltimore: Williams & Wilkins; 1994. p. 151–9.

    Google Scholar 

  52. Sanders DSA. The differential diagnosis of Crohn’s disease and ulcerative colitis. Baillieres Clin Gastroenterol. 1998;12:19–33.

    CAS  PubMed  Google Scholar 

  53. Chiba M. Crohn’s disease associated with diffuse lymphoid hyperplasia of the large intestine: a possible role of the lymph follicle in HLA-Dr expression on epithelium. Intern Med. 1992;31:1271–6.

    CAS  PubMed  Google Scholar 

  54. Rotterdam H, Korelitz BI, Sommers SC. Microgranulomas in grossly normal rectal mucosa in Crohn’s disease. Am J Clin Pathol. 1977;67:550–4.

    CAS  PubMed  Google Scholar 

  55. Surawicz CM, Rubin CE. Epithelioid granuloma and related histologic features which may differentiate Crohn’s disease from ulcerative colitis in rectal biopsies. In: Rachmilewitz D, editor. Inflammatory bowel diseases. The Hague: Martinus Nijhoff Publishers; 1982. p. 19–26.

    Google Scholar 

  56. Sandmeier D, Bouzourene H. Microscopic colitis with giant cells: a rare new histopathologic subtype? Int J Surg Pathol. 2004;12:45–8.

    CAS  PubMed  Google Scholar 

  57. Kayser K, Probst F, Gabius HJ, et al. Are there characteristic alterations of lung tissue associated with Crohn’s disease. Pathol Res Pract. 1990;186:485–90.

    CAS  PubMed  Google Scholar 

  58. Desmet VJ, Geboes K. Liver lesions in inflammatory bowel disorders. J Pathol. 1987;151:247–55.

    CAS  PubMed  Google Scholar 

  59. Van Patter WN, Bargen JA, Dockerty MB, et al. Regional enteritis. Gastroenterology. 1954;26:347–75.

    Google Scholar 

  60. Kelly JK, Sutherland LR. The chronological sequence in the pathology of Crohn’s disease. J Clin Gastroenterol. 1988;10:28–33.

    CAS  PubMed  Google Scholar 

  61. Roberts PL, Schoetz DJ, Pricolo R, et al. Clinical course of Crohn’s disease in older patients. A retrospective study. Dis Colon Rectum. 1990;33:458–62.

    CAS  PubMed  Google Scholar 

  62. Markowitz J, Kahn E, Daum F. Prognostic significance of epithelioid granulomas found in rectosigmoid biopsies at the initial presentation of pediatric Crohn’s disease. J Pediatr Gastroenterol Nutr. 1989;9:182–6.

    CAS  PubMed  Google Scholar 

  63. Pötzi R, Walgram M, Lochs H, et al. Diagnostic significance of endoscopic biopsy in Crohn’s disease. Endoscopy. 1989;21:60–2.

    PubMed  Google Scholar 

  64. Domizio P. Pathology of chronic inflammatory bowel disease in children. Baillieres Clin Gastroenterol. 1994;8:35–63.

    CAS  PubMed  Google Scholar 

  65. Theodossi A, Spiegelhalter DJ, Jass J, et al. Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. Gut. 1994;35:961–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  66. Surawicz CM. Serial sectioning of a portion of a rectal biopsy detects more focal abnormalities. A prospective study of patients with inflammatory bowel disease. Dig Dis Sci. 1982;27:434–6.

    CAS  PubMed  Google Scholar 

  67. Smedh K, Olaison G, Franzén L, et al. Endoscopic and external bowel changes and histopathology in patients with Crohn’s disease. Br J Surg. 1995;82:191–4.

    CAS  PubMed  Google Scholar 

  68. Wolfson DM, Sachar DB, Cohen A, et al. Granulomas do not affect postoperative recurrence rates in Crohn’s disease. Gastroenterology. 1982;83:405–9.

    CAS  PubMed  Google Scholar 

  69. Glass RE, Baker WNW. The role of the granuloma in recurrent Crohn’s disease. Gut. 1976;17:75–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  70. Heresbach D, Alexandre JL, Branger B, et al. Frequency and significance of granulomas in a cohort of incident cases of Crohn’s disease. Gut. 2005;54:215–22.

    CAS  PubMed Central  PubMed  Google Scholar 

  71. Pierik M, De Hertogh G, Vermeire S, et al. Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn’s disease. Gut. 2005;54:223–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  72. Shaoul R, Karban A, Weiss B, et al. NOD2/CARD15 mutations and presence of granulomas in pediatric and adult Crohn’s disease. Inflamm Bowel Dis. 2004;10:709–14.

    PubMed  Google Scholar 

  73. Heresbach D, Gicquel-Douabin V, Birebent B, et al. NOD2/CARD15 gene polymorphism in Crohn’s disease: a genotype phenotype analysis. Eur J Gastroenterol Hepatol. 2004;16:55–62.

    CAS  PubMed  Google Scholar 

  74. Lennard-Jones JE. Crohn’s disease: definition, pathogenesis and aetiology. In: Wright R, editor. Recent advances in gastrointestinal pathology. London: WB Saunders Company; 1980. p. 173–89.

    Google Scholar 

  75. Hamilton SR. Diagnosis and comparison of ulcerative colitis and Crohn’s disease involving the colon. In: Norris HT, editor. Pathology of the colon, small intestine and anus. New York: Churchill Livingstone; 1983. p. 1.

    Google Scholar 

  76. Jenkins D, Balsitis M, Gallivan S, et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol. 1997;50:93–10511.

    CAS  PubMed Central  PubMed  Google Scholar 

  77. Jenkins D, Goodall A, Drew K, et al. What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens. J Clin Pathol. 1988;41:72–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  78. Surawicz CM, Belic L. Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease. Gastroenterology. 1984;86:104–13.

    CAS  PubMed  Google Scholar 

  79. Schmitz-Moormann P, Himmelmann GW. Does quantitative histology of rectal biopsy improve the differential diagnosis of Crohn’s disease and ulcerative colitis in adults? Pathol Res Pract. 1988;183:481–8.

    CAS  PubMed  Google Scholar 

  80. Seldenrijk CA, Morson BC, Meuwissen SGM, et al. Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut. 1991;32:1514–20.

    CAS  PubMed Central  PubMed  Google Scholar 

  81. Shepherd NA. Granulomas in the diagnosis of intestinal Crohn’s disease: a myth exploded. Histopathology. 2002;41:166–8.

    CAS  PubMed  Google Scholar 

  82. Tanaka M, Riddell RH, Saito H, et al. Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn’s disease from ulcerative colitis. Scand J Gastroenterol. 1999;34:55–67.

    CAS  PubMed  Google Scholar 

  83. Tanaka M, Saito H, Fukuda S, et al. Simple mucosal biopsy criteria differentiating among Crohn’s disease, ulcerative colitis and other forms of colitis: measurement of validity. Scand J Gastroenterol. 2000;35:281–6.

    CAS  PubMed  Google Scholar 

  84. Schmitz-Moormann P, Schäg M. Histology of the lower intestinal tract in Crohn’s disease of children and adolescents. Pathol Res Pract. 1990;186:479–84.

    CAS  PubMed  Google Scholar 

  85. Geboes K, Ectors N, D’Haens G, et al. Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of IBD. Am J Gastroenterol. 1998;93:201–6.

    CAS  PubMed  Google Scholar 

  86. Cuvelier C, Demetter P, Mielants H, et al. Interpretation of ileal biopsies: morphological features in normal and diseased mucosa. Histopathology. 2001;38:1–12.

    CAS  PubMed  Google Scholar 

  87. Courville EL, Siegerl CA, Vay T, et al. Isolated asymptomatic ileitis does not progress to overt Crohn disease on long-term follow-up despite features of chronicity in ileal biopsies. Am J Surg Pathol. 2009;33:1341–7.

    PubMed  Google Scholar 

  88. Bentley E, Jenkins D, Campbell F, et al. How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop. J Clin Pathol. 2002;55:955–60.

    CAS  PubMed Central  PubMed  Google Scholar 

  89. Dejaco C, Osterreicher C, Angelberger S, Puspok A, et al. Diagnosing colitis: a prospective study on essential parameters for reaching a diagnosis. Endoscopy. 2003;35:1004–8.

    CAS  PubMed  Google Scholar 

  90. Escher JC, Ten Kate F, Lichtenbelt SK, et al. Value of rectosigmoidoscopy with biopsies for diagnosis of inflammatory bowel disease in children. Inflamm Bowel Dis. 2002;8:16–22.

    PubMed  Google Scholar 

  91. Gomes P, Du Boulay C, Smith CL, et al. Relationship between disease activity and colonoscopic findings in patients with colonic inflammatory bowel disease. Gut. 1986;27:92–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  92. D’Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn’s disease: a European multicenter trial. Gastroenterology. 1999;116:1029–34.

    PubMed  Google Scholar 

  93. Schmitz-Moorman P, Brandes JW, Jesdinsky H, et al. Relationships between drug regime and histology of rectal mucosa in CD. Pathol Res Pract. 1988;183:30–4.

    Google Scholar 

  94. Magro F, Langner C, Driessen A, et al. European Consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis. 2013;7:827–51.

    CAS  PubMed  Google Scholar 

  95. Price AB. Overlap in the spectrum of non-specific inflammatory bowel disease – “colitis indeterminate”. J Clin Pathol. 1978;31:567–77.

    CAS  PubMed Central  PubMed  Google Scholar 

  96. Kent TH, Ammon RK, DenBesten L. Differentiation of ulcerative colitis and regional enteritis. Arch Pathol. 1970;89:20–9.

    CAS  PubMed  Google Scholar 

  97. Lee KS, Medline A, Shockey Q. Indeterminate colitis in the spectrum of inflammatory bowel disease. Arch Pathol Lab Med. 1979;103:173–6.

    CAS  PubMed  Google Scholar 

  98. Branco BC, Harpaz N, Sachar D, et al. Colorectal carcinoma in indeterminate colitis. Inflamm Bowel Dis. 2009;15:1076–81.

    PubMed  Google Scholar 

  99. Geboes K, Colombel JF, Greenstein A, et al. Indeterminate colitis: a review of the concept – what’s in a name? Inflamm Bowel Dis. 2008;14:860–7.

    Google Scholar 

  100. Silverberg M, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a working party of the 2005 Montreal World congress of Gastroenterology. Can J Gastroenterol. 2005;19(Suppl A):1A–32A.

    Google Scholar 

  101. Sonnenberg A, Melton RD, Genta RM. Frequent occurrence of gastritis and duodenitis in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011;17:39–44.

    PubMed  Google Scholar 

  102. Parente F, Cucino C, Bollani S, et al. Focal gastric inflammatory infiltrates in inflammatory bowel diseases. Prevalence, immunohistochemical characteristics and diagnostic role. Am J Gastroenterol. 2000;95:705–11.

    CAS  PubMed  Google Scholar 

  103. Castellaneta SP, Afzzal NA, Greenberg M, et al. Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease. JPGN. 2004;39:257–61.

    CAS  PubMed  Google Scholar 

  104. Lopes S, Figueiredo P, Portela F, et al. Capsule endoscopy in inflammatory bowel disease type unclassified and indeterminate colitis, serologically negative. Inflamm Bowel Dis. 2010;16:1663–8.

    PubMed  Google Scholar 

  105. Auvin S, Molinié F, Gower-Rousseau C, et al. Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in Northern France (1988–1999). J Pediatr Gastroenterol Nutr. 2005;41:49–55.

    PubMed  Google Scholar 

  106. Bentsen BS, Moum B, Ekbom A. Incidence of inflammatory bowel disease in children in Southeastern Norway. A prospective population-based study 1990–94. Scand J Gastroenterol. 2002;37:540–5.

    CAS  PubMed  Google Scholar 

  107. Hildebrand H, Fredrikson B, Holmquist L, et al. Chronic inflammatory bowel disease in children and adolescents in Sweden. J Pediatr Gastroenterol Nutr. 1991;13:293–7.

    CAS  PubMed  Google Scholar 

  108. IBD Working group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis-the Porto criteria. J Pediatr Gastroenterol Nutr. 2005;41:1–7.

    Google Scholar 

  109. Yantiss RK, Farraye FA, O’Brien MJ, et al. Prognostic significance or superficial fissuring ulceration in patients with severe “indeterminate” colitis. Am J Surg Pathol. 2006;30:165–70.

    PubMed  Google Scholar 

  110. Bentley E, Jenkins D, Campbell F, et al. How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop. J Clin Pathol. 2002;55:955–60.

    CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, KULeuven, Gasthuisberg, Leuven, Belgium

    Karel Geboes MD, PhD, AGAF

  2. Department of Pathology, UGhent, Ghent, Belgium

    Karel Geboes MD, PhD, AGAF

  3. Department of Pathology, University of Cagliari, Cagliari, Italy

    Maria Leo, Daniela Fanni MD, PhD & Gavino Faa MD, PhD

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  1. Karel Geboes MD, PhD, AGAF
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  2. Maria Leo
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  3. Daniela Fanni MD, PhD
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  4. Gavino Faa MD, PhD
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Correspondence to Karel Geboes MD, PhD, AGAF .

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  1. Department of pathology, KULeuven, Leuven, Belgium

    Karel Geboes

  2. Department of Pathology, University of Cagliari, Cagliari, Italy

    Sonia Nemolato

  3. Department of Pathology, University of Cagliari, Cagliari, Italy

    Maria Leo

  4. Department of Pathology, University of Cagliari, Cagliari, Italy

    Gavino Faa

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Geboes, K., Leo, M., Fanni, D., Faa, G. (2014). Inflammatory Bowel Diseases. In: Geboes, K., Nemolato, S., Leo, M., Faa, G. (eds) Colitis. Springer, Cham. https://doi.org/10.1007/978-3-319-08028-4_6

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