Abstract
The importance of immunoglobulin G (IgG) molecules for providing long-term sterile immunity as well as their major contribution to tissue inflammation during autoimmune diseases is generally accepted. In a similar manner, studies over the last years have elucidated many details of the molecular and cellular pathways underlying this protective activity in vivo, emphasizing the role of cellular Fc receptors recognizing the constant antibody fragment. In contrast, the active anti-inflammatory activity of IgG, despite being known and actually identified in human autoimmune patients more than 30 years ago, is much less defined. Recent evidence from several independent model systems suggests that IgG glycosylation is critical for the immunomodulatory activity of IgG and that both monomeric IgG as well as IgG immune complexes can diminish Fc receptor and complement dependent inflammatory processes. Moreover, there is increasing evidence that IgG molecules also modulate B and T cell responses, which may suggest that IgG is centrally involved in the establishment and maintenance of immune homeostasis.
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References
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Acknowledgments
We apologize to all our colleagues whose important work could not be cited directly due to limited amount of space. These references can be found in the different review articles cited in the manuscript. This work was supported by grants from the German Research Foundation the Bavarian Genome Research Network, and by the CAVD network within the Bill and Melinda Gates Foundation.
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Böhm, S., Kao, D., Nimmerjahn, F. (2014). Sweet and Sour: The Role of Glycosylation for the Anti-inflammatory Activity of Immunoglobulin G. In: Daeron, M., Nimmerjahn, F. (eds) Fc Receptors. Current Topics in Microbiology and Immunology, vol 382. Springer, Cham. https://doi.org/10.1007/978-3-319-07911-0_18
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