Glaucoma Risk - Correlations between Measurements from Optical Coherence Tomography and Ocular Response Analyzer

Abstract

Glaucoma can lead to blindness if it is not diagnosed in time. To detect it in a patient, a complex assessment is necessary, including: intraocular pressure (IOP) measurements and detection of its influence upon the optic nerve. Our work is based on the hypothesis that retinal nerve fiber layers (RNFL) are influenced by IOP and corneal properties. First, investigations were made with the Reichert Ocular Response Analyzer (ORA) for the intraocular pressure (Goldman- correlated Intraocular Pressure: IOPg, Compensated Intraocular Pressure: IOPc) and corneal properties (Corneal Hysteresis: CH, specific damping capacity: ϕ). Then patients were measured with Optical Coherence Tomography (OCT) for retinal nerve fiber layers thickness: average and superior, inferior, temporal, nasal quadrants. The unified database comprises all these data collected from 4343 eyes and its construction was based on a text extraction method that uses image processing, optical character recognition (OCR) and virtual instrumentation techniques. Appropriate technical data (ORA, OCT) collected, properly computed and judged are very useful in glaucoma diagnosis and management, which is demonstrated in one of the largest databases studied (more than 4,000 eyes measured).