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Vasculitic Neuropathy

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Biopsy Diagnosis of Peripheral Neuropathy

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Abstract

Vasculitis of the peripheral nerve (VPS) can occur as an isolated process or more commonly as the manifestation, initial or late, of a systemic disease (recently reviewed Vrancken and Said 2013; Collins et al. 2013). Inflammation affects endoneurial and epineurial microvessels, arterioles, and venules; thrombosis and necrosis are often present resulting in ischemia of nerve with varying degrees of axonal degeneration. The vasculitic processes detected in routine nerve biopsy specimens (sural, peroneal, median) occur in medium- and small-sized vessels as the diameter of these structures range from 10 to 350 μm.

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Authors and Affiliations

  1. Sunnybrook and St Michael’s Hospitals, University of Toronto, Toronto, ON, Canada

    Juan M. Bilbao MD, FRCP (C) (Professor Emeritus of Neuropathology)

  2. Division of Neuropathology Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA

    Robert E. Schmidt MD, PhD (Professor of Pathology and Immunology Director)

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  1. Juan M. Bilbao MD, FRCP (C)
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Bilbao, J.M., Schmidt, R.E. (2015). Vasculitic Neuropathy. In: Biopsy Diagnosis of Peripheral Neuropathy. Springer, Cham. https://doi.org/10.1007/978-3-319-07311-8_13

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