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History of Liver and Other Splanchnic Organ Transplantation

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Contemporary Liver Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

In the late 1950s, transplant models were developed in dogs for all of the intra-abdominal organs (Fig. 1). The most fruitful of these efforts involved the liver (Table 1) (Starzl TE (1969a) In: Starzl TE (ed) Experience in hepatic transplantation. WB Saunders, Philadelphia). In addition to its direct clinical application, the research in liver transplantation yielded new information about the metabolic interrelations of the intra-abdominal viscera in disease and health; a more profound understanding of the mechanisms of organ alloengraftment; and the addition of new nontransplant procedures to the treatment armamentarium against gastrointestinal diseases.

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References

  • Ackerman JR, Snell ME (1968) Cadaveric renal transplantation. Br J Urol 40:515–521

    Article  Google Scholar 

  • Benichou J, Halgrimson CG, Weil R III et al (1977) Canine and human liver preservation for 6 to 18 hours by cold infusion. Transplantation 24:407–411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Billingham R, Brent L (1956) Quantitative studies on transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of runt disease. Philos Trans R Soc Lond 242:439–477

    Article  Google Scholar 

  • Billingham RE, Krohn PL, Medawar PB (1951) Effect of cortisone on survival of skin homografts in rabbits. Br Med J 1:1157–1163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bismuth H, Houssin D (1984) Reduced-size orthotopic liver graft in hepatic transplantation in children. Surgery 95:367–370

    CAS  PubMed  Google Scholar 

  • Bollman JL (1961) The animal with an Eck fistula. Physiol Rev 41:607–621

    Google Scholar 

  • Brettschneider L, Daloze PM, Huguet C et al (1968a) The use of combined preservation techniques for extended storage of orthotopic liver homografts. Surg Gynecol Obstet 126:263–274

    PubMed  PubMed Central  Google Scholar 

  • Brettschneider L, Tong JL, Boose DS et al (1968b) Specific bacteriologic problems after orthotopic liver transplantation in dogs and pigs. Arch Surg 97:313–322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Broelsch CE, Neuhaus P, Burdelski M et al (1984) Orthotope transplantation von Lebesegmenten bei mit Gallengall8llatresien. (Orthotopic transplantation of hepatic segments in infants with biliary atresia). In: Kolsowski L (ed) Chirurgisches Forum 1984, F Experim U Klimische Forschung Hrsga. Springer, Berlin, pp 105–109

    Google Scholar 

  • Broelsch CE, Emond J, Whitington PF et al (1990) Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants. Ann Surg 212:368–375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Busuttil RW, DeCarlis LG, Mihaylov PV, Gridelli B, Fassati LR, Starzl TE (2012) The first report of orthotopic liver transplantation in the western world. Am J Transplant 12:1385–1387

    Article  CAS  PubMed  Google Scholar 

  • Calne RY (1960) The rejection of renal homografts: inhibition in dogs by 6-mercaptopurine. Lancet 1:417–418

    Article  CAS  PubMed  Google Scholar 

  • Calne RY, Murray JE (1961) Inhibition of the rejection of renal homografts in dogs by Burroughs Wellcome 57-322. Surg Forum 12:118–120

    CAS  PubMed  Google Scholar 

  • Calne RY, Williams R (1968) Liver transplantation in man. I. Observations on technique and organization in five cases. Br Med J 4:535–550

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calne RY, Sells RA, Pena J et al (1969) Induction of immunological tolerance by porcine liver allografts. Nature 223:472–474

    Article  CAS  PubMed  Google Scholar 

  • Calne RY, Rolles K, White DJG et al (1979) Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet 2:1033–1036

    Article  CAS  PubMed  Google Scholar 

  • Carrel A (1902) La technique operatoire des anastomoses vasculaires et la transplantation des visceres. Lyon MEO 98:859–864

    Google Scholar 

  • Child CG, Barr D, Holswade GR, Harrison CS (1953) Liver regeneration following portacaval transposition in dogs. Ann Surg 138:600–608

    Article  PubMed  PubMed Central  Google Scholar 

  • Craddock GN, Nordgren SR, Reznick RD et al (1983) Small bowel transplantation in the dog using cyclosporine. Transplantation 35:284–288

    Article  CAS  PubMed  Google Scholar 

  • Cutropia F, Coratolo F, Spinerta A et al (1972) Experimental orthotopic liver transplantation. Rev Esp Enferm Apar Dig 38:553–570

    Google Scholar 

  • DeJode LR, Howard JM (1962) Studies in pancreaticoduodenal homotransplantation. Surg Gynecol Obstet 114:553–558

    CAS  PubMed  Google Scholar 

  • Deltz E, Ulrich K, Scbach T et al (1986) Graft-versus-host reaction in small bowel transplantation and possibilities for its circumvention. Am J Surg 151:379–386

    Article  CAS  PubMed  Google Scholar 

  • Deltz E, Schroeder P, Gundlach M et al (1990) Successful clinical small-bowel transplantation. Transplant Proc 22:2501

    CAS  PubMed  Google Scholar 

  • Demirleau, Noureddine, Vignes et al (1964) Tentative d’homograffe hepatique (Attempted hepatic homograft). Mem Acad Chir (Paris) 90:177–179

    Google Scholar 

  • Dempster WJ, Lennox B, Boag JW (1950) Prolongation of survival of skin homotransplants in the rabbit by irradiation of the host. Br J Exp Pathol 131:670–679

    Google Scholar 

  • Denmark SW, Shaw BW, Starzl TE, Griffith BP (1983) Veno-venous bypass without systemic anticoagulation in canine and human liver transplantation. Surg Forum 34:380–382

    PubMed  PubMed Central  Google Scholar 

  • Diliz-Perez HS, McClure J et al (1984) Successful small bowel allotransplantations in dogs with cyclosporine and prednisone. Transplantation 37:126–129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fisher B, Russ C, Updegratf H, Fisher ER (1954) Effect of increased hepatic blood flow upon liver regeneration. Arch Surg 69:263–272

    Article  CAS  Google Scholar 

  • Francavilla A, Starzl TE, Porter K et al (1991) Screening for candidate hepatic growth factors by selective portal infusion after canine Eck fistula. Hepatology 14:665–670

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Francavilla A, Hagiya M, Porter KA et al (1994a) Augmenter of liver regeneration (ALR): its place in the universe of hepatic growth factors. Hepatology 20:747–757

    Article  CAS  PubMed  Google Scholar 

  • Francavilla A, Zeng Q, Polimeno L, Carr BI, Sun D, Van Thiel DH, Starzl TE (1994b) Small-for-size liver transplanted into larger recipient: a model of hepatic regeneration. Hepatology 19:210–216

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Franksson C (1984) Survival of homo grafts of skin in rats depleted of lymphocytes by chronic drainage from the thoracic duct. Lancet 1:1331–1332

    Google Scholar 

  • Gandhi CR, Chaillet JR, Nalesnik M et al (2015) Liver-specific deletion of augmenter of liver regeneration induces accelerated steatohepatitis in mice. Gastroenterology 148:379–391

    Article  CAS  PubMed  Google Scholar 

  • Giorda R Haigya M, Seki T et al (1996) Analysis of the structure and expression of ALR gene. Molecular Med 2:97–108

    CAS  Google Scholar 

  • Goodrich EO Jr, Welch HF, Nelson JA et al (1956) Homotransplantation of the canine liver. Surgery 39:244–251

    PubMed  Google Scholar 

  • Goodwin WE, Martin DC (1963) Transplantation of the kidney. Urol Surv 13:229–248

    CAS  PubMed  Google Scholar 

  • Goulet O, Revillon Y, Brousse N et al (1992) Successful small bowel transplantation in an infant. Transplantation 53:940–943

    Article  CAS  PubMed  Google Scholar 

  • Grant O, Duff J, Zhong R et al (1988) Successful intestinal transplantation in pigs treated with cyclosporine. Transplantation 45:279–284

    Article  CAS  PubMed  Google Scholar 

  • Grant D, Wall W, Mimeault R et al (1990) Successful small bowel/liver transplantation. Lancet 335:181–184

    Article  CAS  PubMed  Google Scholar 

  • Griffith BP, Shaw BW, Hardesty RL et al (1985) Venovenous bypass without systemic anticoagulation for transplantation of the human liver. Surg Gynecol Obstet 160:270–272

    CAS  PubMed  PubMed Central  Google Scholar 

  • Groth CG (1972) Landmarks in clinical renal transplantation. Surg Gynecol Obstet 134:323–328

    Google Scholar 

  • Groth CG, Porter KA, Otte JB et al (1968) Studies of blood flow and ultrastructural changes in rejecting and non-rejecting canine orthotopic liver homografts. Surgery 63:31–38

    Google Scholar 

  • Hagiya M, Francavilla A, Polimeno L et al (1994) Cloning and sequence analysis of the rat augmenter of liver regeneration ALR) gene: Expression of biology active recombinant ALR and demonstration of tissue distribution. Proc Natl Acad Sci 91:8142–8146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hamburger J, Vaysse J, Crosnier J et al (1962) Renal homotransplantation in man after radiation of the recipient. Am J Med 32:854–871

    Article  CAS  PubMed  Google Scholar 

  • Houssay BA (1929) Technique de la greffe pancreaticoduodenal au coo. C R Soc Biol 100:138–140

    Google Scholar 

  • Hume DM, Magee JH, Kauffman HM et al (1963) Renal transplantation in man in modified recipients. Ann Surg 158:608–644

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Idezuki Y, Feemster JA, Dietzman RH, Lillehei RE (1968) Experimental pancreaticoduodenal preservation and transplantation. Surg Gynecol Obstet 126:1002–1014

    CAS  PubMed  Google Scholar 

  • Jamieson NY, Sundberg R, Lindell S et al (1988) Successful 24- to 30-hour preservation of the canine liver: a preliminary report. Transplant Proc 20(Suppl 1):945–947

    Google Scholar 

  • Kalayoglu M, Sollinger WH, Stratta RL et al (1988) Extended preservation of the liver for clinical transplantation. Lancet 1:617–619

    CAS  PubMed  Google Scholar 

  • Kam I, Lynch S, Savanas G et al (1987) Evidence that host size determines liver size: studies in dogs receiving orthotopic liver transplants. Hepatology 7:362 366

    Google Scholar 

  • Kamada N (1985) The immunology of experimental liver transplantation in the rat. Immunology 55:369–389

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kang YO, Martin DJ, Marquez J et al (1985) Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg 64:888–896

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kelly WD, Lillehei RC, Merkel FK et al (1967) Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 61:827–837

    CAS  PubMed  Google Scholar 

  • Kuss R, Legrain M, Mathe G et al (1962) Homologous human kidney transplantation. Experience with six patients. Postgrad Med J 38:528–531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lillehei RC, Goon B, Miller FA (1959) The physiologic response of the small bowel of the dog to ischemia, including prolonged in vitro preservation of the bowel with successful replacement and survival. Ann Surg 150:543–560

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mann FC (1944) The William Henry Welch Lectures: II. Restoration and pathologic reactions of the liver. Mt Sinai Hosp II, pp 65–74

    Google Scholar 

  • Marchioro TL, Huntley RT, Waddell WR, Starzl TE (1963) Extracorporeal perfusion for obtaining postmortem homografts. Surgery 54:900–911

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marchioro TL, Axtell HK, LaVia MF et al (1964) The role of adrenocortical steroids in reversing established homograft rejection. Surgery 55:412–417

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marchioro TL, Porter KA, Dickinson TC et al (1965) Physiologic requirements for auxiliary liver homotransplantation. Surg Gynecol Obstet 121:17–31

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marchioro TL, Porter KA, Brown BI et al (1967) The effect of partial portacaval transposition on the canine liver. Surgery 61:723–732

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mazzaferro V, Porter KA, Scotti-Foglieni CL et al (1990) The hepatotrophic influence of cyclosporine. Surgery 107:533–539

    CAS  PubMed  PubMed Central  Google Scholar 

  • McBride RA, Wheeler HB, Smith LL et al (1962) Homotransplantation of the canine liver as an orthotopic vascularized graft. Histologic and functional correlations during residence in the new host. Am J Pathol 41(50):1–520

    Google Scholar 

  • Medawar PB (1944) The behavior and fate of skin autografts and skin homografts in rabbits. J Anat 78:176–199

    CAS  PubMed  PubMed Central  Google Scholar 

  • Medawar PB (1945) Second study of behavior and fate of skin homografis in rabbits. J Anat 79:157

    PubMed Central  Google Scholar 

  • Meeker WR, Condie R, Weiner D et al (1959) Prolongation of skin homograft survival in rabbits by 6-mercaptopurine. Proc Soc Exp BioI Med 102:459–461

    Article  CAS  Google Scholar 

  • Merkel FK, Jonasson O, Bergan JJ (1972) Procurement of cadaver donor organs. Evisceration technique. Transplant Proc 4:585–589

    CAS  PubMed  Google Scholar 

  • Meyer WH Jr, Starzl TE (1959a) The reverse portacaval shunt. Surgery 45:531–534

    Google Scholar 

  • Meyer WH Jr, Starzl TE (1959b) The effect of Eck and reverse Eck fistula in dogs with experimental diabetes mellitus. Surgery 45:760–764

    CAS  PubMed  PubMed Central  Google Scholar 

  • Monchik GJ, Russell PS (1971) Transplantation of the small bowel in the rat: technical and immunologic considerations. Surgery 70:693–702

    CAS  PubMed  Google Scholar 

  • Moore FD (1964) Give and take: the development of tissue transplantation. WB Saunders, Philadelphia

    Google Scholar 

  • Moore FD, Smith LL, Burnap TK et al (1959) One-stage homotransplantation of the liver following total hepatectomy in dogs. Transplant Bull 6:103–110

    Article  CAS  PubMed  Google Scholar 

  • Moore FD, Wheeler HB, Demissianos HV et al (1960) Experimental whole organ transplantation of the liver and of the spleen. Ann Surg 152:374–387

    CAS  PubMed  PubMed Central  Google Scholar 

  • Moore FD, Birtch AG, Dagher F et al (1964) Immunosuppression and vascular insufficiency in liver transplantation. Ann N Y Acad Sci 102:729–738

    Google Scholar 

  • Morgan JA (1951) The influence of cortisone on the survival of homografts of skin in the rabbit. Surgery 30:506–515

    CAS  PubMed  Google Scholar 

  • Murray JE, Merrill JP, Dammin GJ et al (1960) Study of transplantation immunity after total body irradiation: clinical and experimental investigation. Surgery 48:272–284

    CAS  PubMed  Google Scholar 

  • Murray JE, Merrill JP, Dammin GJ et al (1962) Kidney transplantation in modified recipients. Ann Surg 156:337–355

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murray JE, Merrill JP, Harrison JH et al (1963) Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. N Engl J Med 268:1315–1323

    Article  CAS  PubMed  Google Scholar 

  • Najarian JS, Ferguson RM, Sutherland DE et al (1982) Fractionated total lymphoid irradiation as preparative immunosuppression in high risk renal transplantation. Ann Surg 196:442–452

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Picache RS, Kapur BML, Starzl TE (1970) The effect of liver disease on the need for venous decompression during the anhepatic phase of canine orthotopic liver transplantation. Surgery 67:319–321

    CAS  PubMed  PubMed Central  Google Scholar 

  • Putnam CW, Porter KA, Starzl TE (1976) Hepatic encephalopathy and light and electron micrographic changes of the baboon liver after portal diversion. Ann Surg 184:155–161

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramsey G, Nusbacher J, Starzl TE, Lindsay GD (1984) Isohemagglutinins of graft origin after ABO-unmatched liver transplantation. N Engl J Med 311:1167–1170

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ricour C, Revillon Y, Arnaud-Battandier F et al (1983) Successful small bowel allografts in piglets using cyclosporine. Transplant Proc 15:3019–3026

    CAS  Google Scholar 

  • Schwartz R, Dameshek W (1960) The effects of 6-mercaptopurine on homograft reactions. J Clin Invest 39:952–958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shaw BW, Martin DJ, Marquez JM et al (1984) Venous bypass in clinical liver transplantation. Ann Surg 200:524–534

    Article  PubMed  PubMed Central  Google Scholar 

  • Shaw BW Jr, Iwatsuki S, Bron K, Starzl TE (1985) Portal vein grafts in hepatic transplantation. Surg Gynecol Obstet 161:66–68

    PubMed  PubMed Central  Google Scholar 

  • Sheil AGR, Thompson JF, Stevens MS et al (1987) Mesoportal graft for thrombosed portal vein in liver transplantation. Clin Transpl 1:18–21

    Google Scholar 

  • Starzl TE (1960) In Moore et al (1960) Discussion Ann Surg 152:386–387

    Google Scholar 

  • Starzl TE (1964) Experience in renal transplantation. WB Saunders, Philadelphia, pp 68–71

    Google Scholar 

  • Starzl TE (1969a) In: Starzl TE (ed) Experience in hepatic transplantation. WB Saunders, Philadelphia, pp 1–554

    Google Scholar 

  • Starzl TE (1969b) Infectious complications, excluding partial hepatic gangrene. In: Starzl TE (ed) Experience in hepatic transplantation. WB Saunders, Philadelphia, pp 329–347

    Google Scholar 

  • Starzl TE (1969c) Early liver rejection in patients without hepatic gangrene. In: Starzl TE (ed) Experience in hepatic transplantation. WB Saunders, Philadelphia, pp 277–307

    Google Scholar 

  • Starzl TE (1969d) Immunosuppression in man. In: Starzl TE (ed) Experience in hepatic transplantation. WB Saunders, Philadelphia, pp 242–276

    Google Scholar 

  • Starzl TE (1969e) Experience in hepatic transplantation. WB Saunders, Philadelphia, pp 45–48

    Google Scholar 

  • Starzl TE (1992a) A trip south. In: Starzl TE (ed) Puzzle people: memoirs of a transplant surgeon. University of Pittsburgh Press, Pittsburgh, pp 47–58

    Google Scholar 

  • Starzl TE (1992b) The failed liver transplantation trials. In: Starzl TE (ed) The puzzle people: memoirs of a transplant surgeon. University of Pittsburgh Press, Pittsburgh, pp 96–105

    Google Scholar 

  • Starzl TE (1992c) The donors and the organs. In: Starzl TE (ed) The puzzle people: memoirs of a transplant surgeon. University of Pittsburgh Press, Pittsburgh, pp 145–154

    Google Scholar 

  • Starzl TE (1992d) A Pyrrhic victory. In: Starzl TE (ed) The puzzle people: memoirs of a transplant surgeon. University of Pittsburgh Press, Pittsburgh, pp 162–172

    Google Scholar 

  • Starzl TE (1992e) Icebergs and hammer blows. In: Starzl TE (ed) The puzzle people: memoirs of a transplant surgeon. University of Pittsburgh Press, Pittsburgh, pp 173–196

    Google Scholar 

  • Starzl TE (1992f) The little drummer girls. In: Starzl TE (ed) The puzzle people: memoirs of a transplant surgeon. University of Pittsburgh Press, Pittsburgh, pp 318–333

    Google Scholar 

  • Starzl TE (2015a) The birth of organ transplantation: with particular reference to alloengraftment mechanisms. Molecular Medicine 21

    Google Scholar 

  • Starzl TE, Demetris AJ (1990) Liver transplantation: a 31-year perspective. Year Book, Chicago, pp 38–41

    Google Scholar 

  • Starzl TE, Fung JJ (2010) Themes of liver transplantation. Hepatology 51:1869–1884

    Article  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Kaupp HA Jr (1960) Mass homotransplantation of abdominal organs in dogs. Surg Forum 11:28–30

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Terblanche J (1979) Hepatotrophic substances. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol 6. Grone & Stratton, New York, pp 135–152

    Google Scholar 

  • Starzl TE, Bernhard VM, Benvenuto R, Cortes N (1959) A new method for one stage hepatectomy in dogs. Surgery 46:880–886

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Kaupp HA Jr, Brock DR et al (1960) Reconstructive problems in canine liver homotransplantation with special reference to the postoperative role of hepatic venous flow. Surg Gynecol Obstet 111:733–743

    PubMed Central  Google Scholar 

  • Starzl TE, Kaupp HA Jr, Brock DR, Linman JW (1961) Studies on the rejection of the transplanted homologous dog liver. Surg Gynecol Obstet 112:135–144

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Kaupp HA Jr, Brock DR et al (1962) Homotransplantation of multiple visceral organs. Am J Surg 103:219–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Marchioro TL, Waddell WR (1963a) The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg Gynecol Obstet 117:385–395

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Marchioro TL, Talmage DW, Waddel WR (1963b) Splenectomy and thymectomy in human renal transplantation. Proc Soc Exp Biol Med 113:929–932

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Marchioro TL, Von Kaulla KN et al (1963c) Homotransplantation of the liver in humans. Surg Gynecol Obstet 117:659–676

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Marchioro TL, Rowlands DT Jr et al (1964) Immunosuppression after experimental and clinical homotransplantation of the liver. Ann Surg J 60:411–439

    Article  Google Scholar 

  • Starzl TE, Marchioro TL, Porter KA et al (1965) Factors determining short- and long-term survival after orthotopic liver homotransplantation in the dog. Surgery 58:131–155

    PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Marchioro TL, Porter KA et al (1967) The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet 124:301–318

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Groth CG, Brettschneider L et al (1968) Orthotopic homotransplantations of the human liver. Ann Surg 168:392–415

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Putnam CW, Halgrimson CG et al (1971) Cyclophosphamide and whole organ transplantation in humans. Surg Gynecol Obstet 133:981–991

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Francavilla A, Halgrimson CG et al (1973) The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet 137:179–199

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Poner KA, Kashiwagi N et al (1975a) The effect of diabetes mellitus on portal blood hepatotrophic factors in dogs. Surg Gynecol Obstet 140:549–562

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Porter KA, Kashiwagi N, Putnam CW (1975b) Portal hepatotrophic factors, diabetes mellitus and acute live, atrophy, hypertrophy and regeneration. Surg Gynecol Obstet 141:843–858

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Lee IY, Porter KA, Putnam CW (1975c) The influence of portal blood upon lipid metabolism in normal and diabetic dogs and baboons. Surg Gynecol Obstet 140:381–396

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Watanabe K, Porter KA, Putnam CW (1976) Effects of insulin, glucagon, and insulin/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet 1:821–825

    Article  CAS  PubMed  Google Scholar 

  • Starzl TE, Putnam CW, Hansbrough JF et al (1977) Biliary complications after liver transplantation: with special reference to the biliary cast syndrome and techniques of secondary duct repair. Surgery 81:212–221

    CAS  PubMed  Google Scholar 

  • Starzl TE, Francavilla A, Porter KA, Benichou J (1978a) The effect upon the liver of evisceration with or without hormone replacement. Surg Gynecol Obstet 146:524–531

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Francavilla A, Porter KA et al (1978b) The effect of splanchnic viscera removal upon canine liver regeneration. Surg Gynecol Obstet 147:193–207

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Joncs AF, Terblanche J et al (1979a) Growth-stimulating factor in regenerating canine liver. Lancet 1:127–130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Weil R, Koep LJ et al (1979b) Thoracic duct drainage before and after cadaveric kidney transplantation. Surg Gynecol Obstet 149:815–821

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Halgrimson CG, Koep LJ et al (1979c) Vascular homografts from cadaveric organ donors. Surg Gynecol Obstet 149:737

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Weil R, Iwatsuki S et al (1980) The use of cyclosporin A and prednisone in cadaver kidney transplantation. Surg Gynecol Obstet 151:17–26

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Klintmalm GBO, Porter KA et al (1981) Liver transplantation with the use of cyclosporin A and prednisone. N Engl J Med 305:266–269

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Iwatsuki S, van Thiel DH et al (1982) Evolution of liver transplantation. Hepatology 2:614–636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Porter KA, Francavilla A (1983) The Eck fistula in animals and humans. Curr Probl Surg 20:687–752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Hakala TR, Shaw BW Jr et al (1984) A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet 158:223–230

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Miller C, Broznick B, Malcowka L (1987) An improved technique for multiple organ harvesting. Surg Gynecol Obstet 165:343–348

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Rowe M, Todo S et al (1989a) Transplantation of multiple abdominal viscera. JAMA 26:1449–1457

    Article  Google Scholar 

  • Starzl TE, Todo S, Fung J et al (1989b) FK506 for human liver, kidney, and pancreas transplantation. Lancet 2:1000–1004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Todo S, Tzakis A (1989c) Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies. Ann Surg 210:374–386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Van Thiel DH (1989d) Medical progress: liver transplantation, part I. N Engl J Med 321:1014–1022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Van Thiel DH (1989e) Medical progress: liver transplantation, part II. N Engl J Med 321:1092–1099

    Article  CAS  PubMed  Google Scholar 

  • Starzl TE, Schroter GPJ, Hartmann NJ et al (1990) Long term (25 year) survival after renal homotransplantation-the world experience. Transplant Proc 22:2361–2365

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Todo S, Tzakis A et al (1991a) The many faces of multivisceral transplantation. Surg Gynecol Obstet 172:335–344

    CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Porter KA, Mazzaferro V et al (1991b) Hepatotrophic effects of FK 506 in dogs. Transplantation 51:67–70

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Murase N et al (1992) Cell migration, chimerism, and graft acceptance. Lancet 339:1579–1582

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Todo S, Tzakis A, Fung J (1993a) The transplantation of gastrointestinal organs. Gastroenterology 104:673–679

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Trucco M et al (1993b) Cell migration and chimerism after whole organ transplantation: the basis of graft acceptance. Hepatology 17:1127–1152

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Trucco M et al (1993c) Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation 55:1272–1277

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Trucco M et al (1993d) Chimerism after liver transplantation for type IV glycogen storage disease and type I Gaucher’s disease. N Engl J Med 328:745–749

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Demetris AJ, Murase N et al (1996) The lost chord: microchimerism. Immunol Today 17:577–584

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Starzl TE, Murase N, Eghtesad B et al (2015b) Leukocyte chimerism -Meaning and consequences. In: Busuttil RW, Klintmalm GB (eds) The transplantation of the liver, 3rd edn. W.B. Saunders, Philadelphia, pp 1227–1244

    Chapter  Google Scholar 

  • Stieber AC, Zetti G, Todo S et al (1991) The spectrum of portal vein thrombosis. Ann Surg 213:199–206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Strober S, Slavin S, Fuks Z et al (1979) Transplantation tolerance after total lymphoid irradiation. Transplant Proc 11:1032–1038

    CAS  PubMed  Google Scholar 

  • Strong RW, Lynch SV, Ong TH et al (1990) Successful liver transplantation from a living donor to her son. N Engl J Med 322:1505–1507

    Article  CAS  PubMed  Google Scholar 

  • Todo S, Nery J, Yanaga K et al (1989) Extended preservation of human liver grafts with UW solution. JAMA 261:711–714

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Todo S, Fung JJ, Starzl TE et al (1990) Liver, kidney, and thoracic organ transplantation under FK506. Ann Surg 212:295–305

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Todo S, Tzakis AG, Abu-Elmagd K et al (1992) Intestinal transplantation in composite visceral grafts or alone. Ann Surg 216:223–234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Todo S, Tzakis A, Reyes J et al (1993) Intestinal transplantation in humans under FK 506. Transplant Proc 25:1198–1199

    CAS  PubMed  PubMed Central  Google Scholar 

  • Trentin JJ (1956) Mortality and skin transplantability in X-irradiated mice receiving isologous or heterologous bone marrow. Proc Soc Exp Biol Med 92:688–693

    Article  CAS  PubMed  Google Scholar 

  • Tzakis A, Todo S, Starzl TE (1989a) Orthotopic liver transplantation with preservation of the inferior vena cava. Ann Surg 210:649–652

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tzakis A, Todo S, Stieber A, Starzl TE (1989b) Venous jump grafts for liver transplantation in patients with portal vein thrombosis. Transplantation 48:530–531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Valdivia LA, Demetria AJ, Fung JJ et al (1993) Successful hamster to rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin. Transplantation 55:659–661

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wall WJ, CaIne RY, Berbertson BM et al (1977) Simple hypothermic preservation for transporting human livers long distance for transplantation. Transplantation 23:210–216

    Article  CAS  PubMed  Google Scholar 

  • Welch CS (1955) A note on transplantation of the whole liver in dogs. Transplant Bull 2:54–55

    Google Scholar 

  • Woodruff WMA (1960) The transplantation of tissues and organs. Charles C Thomas, Springfield

    Google Scholar 

  • Woodruff MFA, Robson JS, Nolan B et al (1963) Homotransplantation of kidney in patients treated with preoperative administration of antimetabolite (lmuran). Lancet 2:675–682

    Article  CAS  PubMed  Google Scholar 

  • Zukoski CF, Lee HM, Hume DM (1960) The prolongation of functional survival of canine renal homografts by 6-mercaptopurine. Surg Forum 11:470–472

    CAS  PubMed  Google Scholar 

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Starzl, T.E. (2017). History of Liver and Other Splanchnic Organ Transplantation. In: Doria, C. (eds) Contemporary Liver Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07209-8_1

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