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Marine Cyanobacteria Compounds with Anticancer Properties: Implication of Apoptosis

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Handbook of Anticancer Drugs from Marine Origin

Abstract

Marine cyanobacteria have been proved to be an important source of potential anticancer drugs. Although several compounds were found to be cytotoxic to cancer cells in culture, the pathways by which cells are affected are still poorly elucidated. For some compounds, cancer cell death was attributed to an implication of apoptosis through morphological apoptotic features, implication of caspases and proteins of the Bcl-2 family, and other mechanisms such as interference with microtubules dynamics, cell cycle arrest and inhibition of proteases other than caspases.

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Acknowledgements

The authors would like to acknowledge the European Regional Development Fund (ERDF) through the COMPETE—Operational Competitiveness Program and national funds through FCT—Foundation for Science and Technology, under the project PTDC/MAR/102638/2008, and partially under the projects PEst-C/MAR/LA0015/2013 and MARBIOTECH (reference NORTE-07-0124-FEDER-000047), co-financed by the North Portugal Regional Operational Programme (ON.2—O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).

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Authors and Affiliations

  1. Health and Environmental Research Center, Superior School of Allied Health Sciences of Porto, Polytechnic Institute of Porto, Rua Valente Perfeito, 322, 4400-330, Vila Nova de Gaia, Portugal

    Dr. Maria do Rosário Martins & Margarida Costa

  2. Interdisciplinary Centre of Marine and Environmental Research—CIIMAR/CIMAR, Porto University, Porto, Portugal

    Dr. Maria do Rosário Martins & Margarida Costa

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  1. Dr. Maria do Rosário Martins
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  2. Margarida Costa
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Correspondence to Maria do Rosário Martins .

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Editors and Affiliations

  1. Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

    Se-Kwon Kim

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do Rosário Martins, M., Costa, M. (2015). Marine Cyanobacteria Compounds with Anticancer Properties: Implication of Apoptosis. In: Kim, SK. (eds) Handbook of Anticancer Drugs from Marine Origin. Springer, Cham. https://doi.org/10.1007/978-3-319-07145-9_29

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