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Plant Peroxisomal ABC Transporters: Flexible and Unusual

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Plant ABC Transporters

Part of the book series: Signaling and Communication in Plants ((SIGCOMM,volume 22))

Abstract

ABC transporters of subfamily D mediate import of substrates for β-oxidation into peroxisomes. Whilst mammals possess three peroxisomal ABCD proteins which homodimerise to form transporters with distinct substrate specificities, Baker’s yeast has a single transporter formed by heterodimerisation, which imports long-chain fatty acyl CoAs. Plants have a single-fused heterodimer transporter that exhibits broad substrate specificity, reflecting the wide range of β-oxidation substrates processed by plants. The fusion appears to have occurred early in the evolution of land plants and was followed by an early duplication event in the monocot lineage. Plant ABCD proteins function in all stages of the life cycle and their physiological roles reflect the ability to transport diverse substrates including saturated and unsaturated fatty acids and aromatic compounds such as precursors of hormones and secondary metabolites. Recent work suggests that transport of CoA substrates involves their cleavage and re-esterification within the peroxisome, thus interaction with appropriate acyl adenylate-activating enzymes potentially provides a mechanism for regulating entry of different substrates into β-oxidation. The mechanism of ABCD transporter targeting is broadly conserved across kingdoms but evidence suggests the regulation of protein turnover differs.

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Abbreviations

ABA:

Abscisic acid

ABC:

ATP-binding cassette

ABCD:

ABC transporter, subfamily D

ALDP:

Adrenoleukodystrophy protein

ALDR:

Adrenoleukodystrophy-related protein

CoA:

Coenzyme A

CTS:

Comatose

2,4-DB:

2,4-Dichlorophenoxybutyrate

ER:

Endoplasmic reticulum

IAA:

Indole acetic acid

IBA:

Indole butyric acid

JA:

Jasmonic acid

LACS:

Long-chain fatty acyl CoA synthetase

LCFA:

Long-chain fatty acid

MCFA:

Medium chain fatty acid

NBD:

Nucleotide-binding domain

OPDA:

12-Oxophytodienoic acid

PMP:

Peroxisomal membrane protein

PMP69:

69 kDa PMP

PMP70:

70 kDa PMP

TAG:

Triacylglycerol

TMD:

Transmembrane domain

VLACS:

Very long-chain fatty acyl CoA synthetase

VLCFA:

Very long-chain fatty acid

X-ALD:

X-linked adrenoleukodystrophy

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Acknowledgements

ABC transporter research in the authors’ labs is supported by BBSRC grants: BB/L001691/1 and BB/L001012/1. Rothamsted Research receives grant-aided support from the BBSRC of the UK.

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Authors and Affiliations

  1. Biological Chemistry and Crop Protection Department, Rothamsted Research, Harpenden, AL5 2JQ, UK

    Frederica L. Theodoulou

  2. Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK

    Stephen A. Baldwin & Jocelyn M. Baldwin

  3. Centre for Plant Sciences, School of Biology, University of Leeds, Leeds, LS2 9JT, UK

    Alison Baker

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  1. Frederica L. Theodoulou
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  2. Stephen A. Baldwin
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  3. Jocelyn M. Baldwin
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  4. Alison Baker
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Correspondence to Frederica L. Theodoulou .

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  1. Plant Biology, University of Fribourg Department of Biology, Fribourg, Switzerland

    Markus Geisler

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Theodoulou, F.L., Baldwin, S.A., Baldwin, J.M., Baker, A. (2014). Plant Peroxisomal ABC Transporters: Flexible and Unusual. In: Geisler, M. (eds) Plant ABC Transporters. Signaling and Communication in Plants, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-06511-3_6

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