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Proteomic Approaches to Dissect Neuronal Signaling Pathways

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Advancements of Mass Spectrometry in Biomedical Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 806))

Abstract

With an increasing awareness of mental health issues and neurological disorders, “understanding the brain” is one of the biggest current challenges in biological research. This has been recognized by both governments and funding agencies, and includes the need to understand connectivity of brain regions and coordinated network activity, as well as cellular and molecular mechanisms at play. In this chapter, we will describe how we have taken advantage of different proteomic techniques to unravel molecular mechanisms underlying two modulators of neuronal function: Neurotrophins and antipsychotics.

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Acknowledgment

This work was supported by the Human Frontiers Science Program and the FNES start-up award (KD).

Author information

Authors and Affiliations

  1. Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, 10016, USA

    Heather L. Bowling

  2. Institute for Life Sciences and Centre for Biological Sciences, University of Southampton, Life Sciences Building 85, Southampton, SO17 1BJ, UK

    Katrin Deinhardt

Authors
  1. Heather L. Bowling
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  2. Katrin Deinhardt
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Corresponding author

Correspondence to Katrin Deinhardt .

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Editors and Affiliations

  1. Chemistry and Biomolecular Science Biochemistry and Proteomics Group, Clarkson University, Potsdam, New York, USA

    Alisa G. Woods

  2. Chemistry and Biomolecular Science Biochemistry and Proteomics Group, Clarkson University, Potsdam, New York, USA

    Costel C. Darie

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© 2014 Springer International Publishing Switzerland

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Bowling, H.L., Deinhardt, K. (2014). Proteomic Approaches to Dissect Neuronal Signaling Pathways. In: Woods, A., Darie, C. (eds) Advancements of Mass Spectrometry in Biomedical Research. Advances in Experimental Medicine and Biology, vol 806. Springer, Cham. https://doi.org/10.1007/978-3-319-06068-2_24

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