Abstract
Cardiac imaging has an important role not only in the diagnosis of hypertrophic cardiomyopathy (HCM) but also in prognostic stratification. HCM is a disease with a variable course and outcome. Some cases are asymptomatic, with an excellent long-term survival, but some patients die suddenly or evolve toward a more severe disease, with heart failure (HF) and systolic function impairment. Cardiac imaging allows a thorough assessment of structural and functional features and identifies several risk factors to help the clinician discriminate severe disease from a more benign condition. Multiparametric imaging evaluation using echocardiography, cardiac magnetic resonance (CMR), and other techniques—such as positron emission tomography (PET)—increase the ability to stratify the outcome of these patients.
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References
Maron BJ, Maron MS (2013) Hypertrophic cardiomyopathy. Lancet 381(9862):242–255. doi:10.1016/S0140-6736(12)60397-3
O’Mahony C, Jichi F, Pavlou M, Monserrat L, Anastasakis A, Rapezzi C, Biagini E, Gimeno JR, Limongelli G, McKenna WJ, Omar RZ, Elliott PM (2013) A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM Risk-SCD). Eur Heart J. doi:10.1093/eurheartj/eht439
Spirito P, Bellone P, Harris KM, Bernabo P, Bruzzi P, Maron BJ (2000) Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl J Med 342(24):1778–1785. doi:10.1056/NEJM200006153422403
Elliott PM, Gimeno Blanes JR, Mahon NG, Poloniecki JD, McKenna WJ (2001) Relation between severity of left-ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy. Lancet 357(9254):420–424. doi:10.1016/S0140-6736(00)04005-8
Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW (2011) 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol 58(25):e212–e260. doi:10.1016/j.jacc.2011.06.011
Pinamonti B, Di Lenarda A, Nucifora G, Gregori D, Perkan A, Sinagra G (2008) Incremental prognostic value of restrictive filling pattern in hypertrophic cardiomyopathy: a Doppler echocardiographic study. Eur J Echocardiogr 9(4):466–471. doi:10.1016/j.euje.2007.06.008
Biagini E, Spirito P, Rocchi G, Ferlito M, Rosmini S, Lai F, Lorenzini M, Terzi F, Bacchi-Reggiani L, Boriani G, Branzi A, Boni L, Rapezzi C (2009) Prognostic implications of the Doppler restrictive filling pattern in hypertrophic cardiomyopathy. Am J Cardiol 104(12):1727–1731. doi:10.1016/j.amjcard.2009.07.057
Kitaoka H, Kubo T, Hayashi K, Yamasaki N, Matsumura Y, Furuno T, Doi YL (2013) Tissue Doppler imaging and prognosis in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging 14(6):544–549. doi:10.1093/ehjci/jes200
Pagourelias ED, Efthimiadis GK, Parcharidou DG, Gossios TD, Kamperidis V, Karoulas T, Karvounis H, Styliadis IH (2011) Prognostic value of right ventricular diastolic function indices in hypertrophic cardiomyopathy. Eur J Echocardiogr 12(11):809–817. doi:10.1093/ejechocard/jer126
Lonborg JT, Engstrom T, Moller JE, Ahtarovski KA, Kelbaek H, Holmvang L, Jorgensen E, Helqvist S, Saunamaki K, Soholm H, Andersen M, Mathiasen AB, Kuhl JT, Clemmensen P, Kober L, Vejlstrup N (2013) Left atrial volume and function in patients following ST elevation myocardial infarction and the association with clinical outcome: a cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging 14(2):118–127. doi:10.1093/ehjci/jes118
Olivotto I, Cecchi F, Casey SA, Dolara A, Traverse JH, Maron BJ (2001) Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy. Circulation 104(21):2517–2524
Nistri S, Olivotto I, Betocchi S, Losi MA, Valsecchi G, Pinamonti B, Conte MR, Casazza F, Galderisi M, Maron BJ, Cecchi F (2006) Prognostic significance of left atrial size in patients with hypertrophic cardiomyopathy (from the Italian Registry for Hypertrophic Cardiomyopathy). Am J Cardiol 98(7):960–965. doi:10.1016/j.amjcard.2006.05.013
Finocchiaro G, Pinamonti B, Merlo M, Brun F, Barbati G, Sinagra G (2012) Prognostic role of clinical presentation in symptomatic patients with hypertrophic cardiomyopathy. J Cardiovasc Med (Hagerstown) 13(12):810–818. doi:10.2459/JCM.0b013e328356a231
Maron MS, Olivotto I, Zenovich AG, Link MS, Pandian NG, Kuvin JT, Nistri S, Cecchi F, Udelson JE, Maron BJ (2006) Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation 114(21):2232–2239. doi:10.1161/CIRCULATIONAHA.106.644682
Maron MS, Olivotto I, Betocchi S, Casey SA, Lesser JR, Losi MA, Cecchi F, Maron BJ (2003) Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 348(4):295–303. doi:10.1056/NEJMoa021332
Elliott PM, Gimeno JR, Tome MT, Shah J, Ward D, Thaman R, Mogensen J, McKenna WJ (2006) Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. Eur Heart J 27(16):1933–1941. doi:10.1093/eurheartj/ehl041
Efthimiadis GK, Parcharidou DG, Giannakoulas G, Pagourelias ED, Charalampidis P, Savvopoulos G, Ziakas A, Karvounis H, Styliadis IH, Parcharidis GE (2009) Left ventricular outflow tract obstruction as a risk factor for sudden cardiac death in hypertrophic cardiomyopathy. Am J Cardiol 104(5):695–699. doi:10.1016/j.amjcard.2009.04.039
Olivotto I, Cecchi F, Poggesi C, Yacoub MH (2012) Patterns of disease progression in hypertrophic cardiomyopathy: an individualized approach to clinical staging. Circ Heart Fail 5(4):535–546. doi:10.1161/CIRCHEARTFAILURE.112.967026
Pinamonti B, Merlo M, Nangah R, Korcova R, Di Lenarda A, Barbati G, Sinagra G (2010) The progression of left ventricular systolic and diastolic dysfunctions in hypertrophic cardiomyopathy: clinical and prognostic significance. J Cardiovasc Med (Hagerstown) 11(9):669–677. doi:10.2459/JCM.0b013e3283383355
Yacoub MH, Olivotto I, Cecchi F (2007) ‘End-stage’ hypertrophic cardiomyopathy: from mystery to model. Nat Clin Pract Cardiovasc Med 4(5):232–233. doi:10.1038/ncpcardio0859
O’Hanlon R, Grasso A, Roughton M, Moon JC, Clark S, Wage R, Webb J, Kulkarni M, Dawson D, Sulaibeekh L, Chandrasekaran B, Bucciarelli-Ducci C, Pasquale F, Cowie MR, McKenna WJ, Sheppard MN, Elliott PM, Pennell DJ, Prasad SK (2010) Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol 56(11):867–874. doi:10.1016/j.jacc.2010.05.010
Green JJ, Berger JS, Kramer CM, Salerno M (2012) Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. JACC Cardiovasc Imaging 5(4):370–377. doi:10.1016/j.jcmg.2011.11.021
Alla VM, Koneru S, Hunter C, Mooss A (2012) LGE and the risk of sudden death in HCM. JACC Cardiovasc Imaging 5(7):761–762; author reply 762–763. doi:10.1016/j.jcmg.2012.05.004
Adabag AS, Maron BJ, Appelbaum E, Harrigan CJ, Buros JL, Gibson CM, Lesser JR, Hanna CA, Udelson JE, Manning WJ, Maron MS (2008) Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed enhancement on cardiovascular magnetic resonance. J Am Coll Cardiol 51(14):1369–1374. doi:10.1016/j.jacc.2007.11.071
Todiere G, Aquaro GD, Piaggi P, Formisano F, Barison A, Masci PG, Strata E, Bacigalupo L, Marzilli M, Pingitore A, Lombardi M (2012) Progression of myocardial fibrosis assessed with cardiac magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol 60(10):922–929. doi:10.1016/j.jacc.2012.03.076
Olivotto I, Girolami F, Sciagra R, Ackerman MJ, Sotgia B, Bos JM, Nistri S, Sgalambro A, Grifoni C, Torricelli F, Camici PG, Cecchi F (2011) Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations. J Am Coll Cardiol 58(8):839–848. doi:10.1016/j.jacc.2011.05.018
Camici P, Chiriatti G, Lorenzoni R, Bellina RC, Gistri R, Italiani G, Parodi O, Salvadori PA, Nista N, Papi L et al (1991) Coronary vasodilation is impaired in both hypertrophied and nonhypertrophied myocardium of patients with hypertrophic cardiomyopathy: a study with nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol 17(4):879–886
Olivotto I, Cecchi F, Gistri R, Lorenzoni R, Chiriatti G, Girolami F, Torricelli F, Camici PG (2006) Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy. J Am Coll Cardiol 47(5):1043–1048. doi:10.1016/j.jacc.2005.10.050
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Finocchiaro, G., Pinamonti, B., Abate, E., Merlo, M., Vitrella, G. (2014). Hypertrophic Cardiomyopathy: Usefulness of Imaging in Prognostic Stratification and Choice of Treatment. In: Pinamonti, B., Sinagra, G. (eds) Clinical Echocardiography and Other Imaging Techniques in Cardiomyopathies. Springer, Cham. https://doi.org/10.1007/978-3-319-06019-4_13
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DOI: https://doi.org/10.1007/978-3-319-06019-4_13
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