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mRNA Localization

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Fungal RNA Biology

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Abstract

mRNA localization and localized translation is a common mechanism that contributes to cell polarity and cellular asymmetry. In metazoans, mRNA transport participates in embryonic axis determination and neuronal plasticity. Since the dissection of the mRNA localization process and its molecular machinery in higher eukaryotes has been found to be more arduous, unicellular eukaryotes like Saccharomyces cerevisiae or Ustilago maydis have become attractive models to study mRNA localization. Especially studies on cytoplasmic mRNA transport in S. cerevisiae have provided mechanistic insights as well as novel experimental approaches to mRNA localization, which have proven valuable for understanding similar processes in metazoans. In this review we will focus on mRNA localization of ASH1 and other bud-localized mRNA in S. cerevisiae in order to provide a holistic view on mRNA localization. In addition, we will dwell on the mechanism and biological function of additional mRNA localization processes in budding yeast. Finally, we will compare mRNA transport in budding yeast with similar localization processes occurring in other fungi including the ascomycete Candida albicans and the basidiomycete U. maydis.

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  1. Interfaculty Institute of Biochemistry, Universität Tübingen, 72076, Tübingen, Germany

    Balaji T. Moorthy & Ralf-Peter Jansen

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  1. Balaji T. Moorthy
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  2. Ralf-Peter Jansen
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Correspondence to Ralf-Peter Jansen .

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  1. Centre for Plant Biotechnology and Genom, Universidad Politécnica de Madrid, Pozuelo de Alarcón (Madrid), Spain

    Ane Sesma

  2. Kent Fungal Group School of Biosciences, University of Kent, Kent, United Kingdom

    Tobias von der Haar

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© 2014 Springer International Publishing Switzerland

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Moorthy, B.T., Jansen, RP. (2014). mRNA Localization. In: Sesma, A., von der Haar, T. (eds) Fungal RNA Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-05687-6_6

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