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High-Throughput Screening, Microfluidics, Biosensors, and Real-Time Phenotyping

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Stem Cell Engineering

Part of the book series: Science Policy Reports ((SCIPOLICY))

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Abstract

Key opportunities for the field of stem cell engineering involve identification of cues that regulate stem cell fate, constructing a systems level understanding of how cells sense and process information provided by the microenvironment, and designing environments to elicit the desired cell fate. Meeting these opportunities will be facilitated by collaborative, interdisciplinary interactions among engineers, scientists, and clinicians. Chapters “Physical and Engineering Principles in Stem Cell Research” and “Computational Modeling and Stem Cell Engineering” in this report address the principles by which physical cues can affect stem cells and how mathematical modeling can provide insight into mechanisms of stem cell regulation. For these efforts to be successful, spatial and dynamic control over the microenvironment is needed. This chapter will focus on how recent advances in cell culture platform design and manufacture permit systematic application of regulatory cues to stem cells, and the insight these systems have provided in stem cell biology and engineering.

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Authors and Affiliations

  1. Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 3637 Engineering Hall, 1415 Engineering Drive, Madison, WI, 53706-1691, USA

    Sean P. Palecek

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  1. Sean P. Palecek
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Correspondence to Sean P. Palecek .

Editor information

Editors and Affiliations

  1. Parker H Petit Institute for Bioeng. & Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA

    Robert M. Nerem

  2. Chemical Physiology, The Centre for Regenerative Medicine Scripps Research Inst., San Diego, California, USA

    Jeanne Loring

  3. Biomedical Engineering, Stem Cell Engineering Center Georgia Institute of Technology, Atlanta, Georgia, USA

    Todd C. McDevitt

  4. Chemical & Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Sean P. Palecek

  5. Berkeley Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California, USA

    David V. Schaffer

  6. University of Toronto, Terrence Donnelly Centre for Cellular & Biomolecular Research, Toronto, Ontario, Canada

    Peter W. Zandstra

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Palecek, S.P. (2014). High-Throughput Screening, Microfluidics, Biosensors, and Real-Time Phenotyping. In: Nerem, R., Loring, J., McDevitt, T., Palecek, S., Schaffer, D., Zandstra, P. (eds) Stem Cell Engineering. Science Policy Reports. Springer, Cham. https://doi.org/10.1007/978-3-319-05074-4_3

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