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Biomolecule Attachment to Porous Silicon

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Handbook of Porous Silicon

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Abstract

Porous silicon is utilized in a variety of interdisciplinary and applied fields such as medical diagnostics, tissue engineering, vaccine development, drug delivery, and biomedical imaging and sensing. As a result, the interest in the chemistry of porous silicon is focused on the generation of functional nanostructures to graft molecules such as drugs, proteins, targeting agents, or biological receptor molecules to these porous surfaces. For the immobilization of such biomolecules to porous silicon, it is important to have a stable base layer which can be achieved by a number of strategies including oxidation, polymer modification, and a variety of different self-assembled monolayer systems. Once the base layer is formed that present moieties on their distal end compatible with bioconjugation chemistry, various biomolecules can then be added to the construct. The first part of this review discusses such strategies to attach the biomolecule to the modified porous silicon surface along with the discussion of the key components of the interfacial design. The bioconjugation strategy involves a linker molecule that connects the biologically active species to the porous surface. To attach a biological species to an immobilized linker, an activating step is usually employed to allow formation of a covalent bond between the species and the linker. The second part of the chapter covers the applications of biomolecule attachment using porous silicon.

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Authors and Affiliations

  1. School of Chemistry, The Australian Centre for NanoMedicine and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, UNSW Australia, Sydney, NSW, Australia

    Bakul Gupta & J. Justin Gooding

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  1. Bakul Gupta
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  2. J. Justin Gooding
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Correspondence to Bakul Gupta .

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  1. Malvern Hills Science Park, Chief Scientific Officer, Intrinsiq Mate, Malvern, Worcestershire, United Kingdom

    Leigh Canham

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Gupta, B., Gooding, J. (2016). Biomolecule Attachment to Porous Silicon. In: Canham, L. (eds) Handbook of Porous Silicon. Springer, Cham. https://doi.org/10.1007/978-3-319-04508-5_115-1

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  • DOI: https://doi.org/10.1007/978-3-319-04508-5_115-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-04508-5

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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