Abstract
Thrombotic Thrombocytopenic Purpura (TTP) is a syndrome marked by waxing and waning episodes of organ and tissue ischemia secondary to reversible platelet aggregation in the microvasculature. It often presents with thrombocytopenia, microangiopathic hemolytic anemia, neurologic symptoms, fever and renal abnormalities. Without treatment the mortality rate may reach 90 %. TTP is usually acquired although inherited chronically relapsing forms also occur.
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Suggested Further Reading
Dubois L, Gray DK. Splenectomy: does it still play a role in the treatment of thrombocytopenic purpura? Can J Surg. 2010;53(5):349–55.
Wilson DB, Chapter 33: Acquired Platelet Defects. In: Nathan DG, Oski FA, editors. Textbook of hematology of infancy and childhood. 7th ed., Saunders, Philadelphia, 2009; p. 1571–3.
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Taylor, J.S. (2014). Thrombotic Thrombocytopenic Purpura. In: Coppola, C., Kennedy, Jr., A., Scorpio, R. (eds) Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-04340-1_54
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DOI: https://doi.org/10.1007/978-3-319-04340-1_54
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