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Robinson annulation

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Name Reactions

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Abstract

Michael addition of cyclohexanones to methyl vinyl ketone followed by intramolecular aldol condensation to afford six-membered α,β-unsaturated ketones.

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References

  1. Rapson, W. S.; Robinson, R. J. Chem. Soc. 1935, 1285–1288. Robert Robinson used the Robinson annulaton in his total synthesis of cholesterol. Here is a story told by Derek Barton about Robinson and Woodward: “By pure chance, the two great men met early in a Monday morning on an Oxford train station platform in 1951. Robinson politely asked Woodward what kind of research he was doing these days; Woodward replied that he thought that Robinson would be interested in his recent total synthesis of cholesterol. Robinson, incensed and shouting ‘Why do you always steal my research topic?’, hit Woodward with his umbrella.”—An excerpt from Barton, Derek, H. R. Some Recollections of Gap Jumping, American Chemical Society, Washington, D.C., 1991.

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Authors and Affiliations

  1. Department of Chemistry College of Arts and Sciences, University of San Francisco, San Francisco, CA, USA

    Jie Jack Li

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  1. Jie Jack Li
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Li, J.J. (2014). Robinson annulation. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_234

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