Abstract
Amine synthesis from reductive amination of a ketone and an amine in the presence of excess formic acid, which serves as the reducing reagent by delivering a hydride.
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Leuckart, R. Ber. 1885, 18, 2341––2344. Carl L. R. A. Leuckart (1854–1889) was born in Giessen, Germany. After studying under Bunsen, Kolbe, and von Baeyer, he became an assistant professor at Göttingen. Unfortunately, chemistry lost a brilliant contributor by his sudden death at age 35 as a result of a fall in his parent’s house.
Wallach, O. Ann. 1892, 272, 99. Otto Wallach (1847–1931), born in Königsberg, Prussia, studied under Wöhler and Hofmann. He was the director of the Chemical Institute at Göttingen from 1889 to 1915. His book “Terpene und Kampfer” served as the foundation for future work in terpene chemistry. Wallach was awarded the Nobel Prize in Chemistry in 1910 for his work on alicyclic compounds.
Moore, M. L. Org. React. 1949, 5, 301–330. (Review).
DeBenneville, P. L.; Macartney, J. H. J. Am. Chem. Soc. 1950, 72, 3073–3075.
Lukasiewicz, A. Tetrahedron 1963, 19, 1789–1799. (Mechanism).
Bach, R. D. J. Org. Chem. 1968, 33, 1647–1649.
Musumarra, G.; Sergi, C. Heterocycles 1994, 37, 1033–1039.
Martínez, A. G.; Vilar, E. T.; Fraile, A. G.; Ruiz, P. M.; San Antonio, R. M.; Alcazar, M. P. M. Tetrahedron: Asymmetry 1999, 10, 1499–1505.
Kitamura, M.; Lee, D.; Hayashi, S.; Tanaka, S.; Yoshimura, M. J. Org. Chem. 2002, 67, 8685–8687.
Brewer, A. R. E. Leuckart–Wallach reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 451–455. (Review).
Muzalevskiy, V. M.; Nenajdenko, V. G.; Shastin, A. V.; Balenkova, E. S.; Haufe, G. J. Fluorine Chem. 2008, 129, 1052–1055.
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Li, J.J. (2014). Leuckart–Wallach reaction. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_156
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DOI: https://doi.org/10.1007/978-3-319-03979-4_156
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