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Grignard reaction

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Abstract

Addition of organomagnesium compounds (Grignard reagents), generated from organohalides and magnesium metal, to electrophiles.

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References

  1. Grignard, V. C. R. Acad. Sci. 1900, 130, 1322–1324. Victor Grignard (France, 1871–1935) won the Nobel Prize in Chemistry in 1912 for his discovery of the Grignard reagent.

    Google Scholar 

  2. Ashby, E. C.; Laemmle, J. T.; Neumann, H. M. Acc. Chem. Res. 1974, 7, 272–280. (Review).

    Google Scholar 

  3. Ashby, E. C.; Laemmle, J. T. Chem. Rev. 1975, 75, 521–546. (Review).

    Google Scholar 

  4. Sasaki, T.; Eguchi, S.; Hattori, S. Heterocycles 1978, 11, 235–242.

    Article  CAS  Google Scholar 

  5. Meyers, A. I.; Flisak, J. R.; Aitken, R. A. J. Am. Chem. Soc. 1987, 109, 5446–5452.

    Article  CAS  Google Scholar 

  6. Grignard Reagents Richey, H. G., Jr., Ed.; Wiley: New York, 2000. (Book).

    Google Scholar 

  7. Holm, T.; Crossland, I. In Grignard Reagents Richey, H. G., Jr., Ed.; Wiley: New York, 2000, Chapter 1, pp 1–26. (Review).

    Google Scholar 

  8. Shinokubo, H.; Oshima, K. Eur. J. Org. Chem. 2004, 2081–2091. (Review).

    Google Scholar 

  9. Graden, H.; Kann, N. Cur. Org. Chem. 2005, 9, 733–763. (Review).

    Google Scholar 

  10. Babu, B. N.; Chauhan, K. R. Tetrahedron Lett. 2008, 50, 66–67.

    Article  Google Scholar 

  11. Mlinaric-Majerski, K.; Kragol, G.; Ramljak, T. S. Synlett 2008, 405–409.

    Google Scholar 

  12. Mao, B.; Fãnás-Mastral, M.; Feringa, B. L. Org. Lett. 2013, 15, 286–289.

    Article  CAS  Google Scholar 

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Li, J.J. (2014). Grignard reaction. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_122

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