Skip to main content
SpringerLink
Log in

Pathological Considerations in Crohn’s Disease

  • Chapter
  • First Online:
Crohn's Disease

  • 2565 Accesses

Abstract

Crohn’s disease (CD) is a chronic inflammatory condition of the gastro-intestinal tract. This chapter illustrates the typical macroscopic and microscopic pathology appearances of CD. The effect of treatment on these appearances and the main differential diagnoses are also described. The pathological diagnosis of Crohn’s disease can be challenging. Comprehensive clinical, radiological and endoscopic information is vital for the pathologist to reach the correct diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hadfield G. The primary histological lesion of Crohn’s disease. Lancet. 1939;2:773–5.

    Article  Google Scholar 

  2. Sheehan AL, Warren BF, Gear MW, Shepherd NA. Fat-wrapping in Crohn’s disease: pathological basis and relevance to surgical practice. Br J Surg. 1992;79(9):955–8.

    Article  CAS  PubMed  Google Scholar 

  3. Heaton KW, McCarthy CF, Horton RE, Cornes JS, Read AE. Miliary Crohn’s disease. Gut. 1967;​8(1):4–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Thompson EM, Clayden G, Price AB. Cancer in Crohn’s disease–an ‘occult’ malignancy. Histopathology. 1983;7(3):365–76.

    Article  CAS  PubMed  Google Scholar 

  5. Woodley HE, Spencer JA, MacLennan KA. Small-bowel lymphoma complicating long-standing Crohn’s disease. AJR Am J Roentgenol. 1997;169(5):1462–3.

    Article  CAS  PubMed  Google Scholar 

  6. Sigel JE, Goldblum JR. Neuroendocrine neoplasms arising in inflammatory bowel disease: a report of 14 cases. Mod Pathol. 1998;11(6):537–42.

    CAS  PubMed  Google Scholar 

  7. Peyrin-Biroulet L, Loftus Jr EV, Colombel JF, Sandborn WJ. Long-term complications, extraintestinal manifestations, and mortality in adult Crohn’s disease in population-based cohorts. Inflamm Bowel Dis. 2011;17(1):471–8.

    Article  PubMed  Google Scholar 

  8. Vavricka SR, Brun L, Ballabeni P, Pittet V, Prinz Vavricka BM, Zeitz J, et al. Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort. Am J Gastroenterol. 2011;106(1):110–9.

    Article  PubMed  Google Scholar 

  9. Geboes K, Ectors N, D’Haens G, Rutgeerts P. Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of inflammatory bowel disease? Am J Gastroenterol. 1998;93(2):201–6.

    Article  CAS  PubMed  Google Scholar 

  10. Schmitz-Moormann P, Pittner PM, Malchow H, Brandes JW. The granuloma in Crohn’s disease. A bioptical study. Pathol Res Pract. 1984;178(5):467–76.

    Article  CAS  PubMed  Google Scholar 

  11. Jenkins D, Balsitis M, Gallivan S, Dixon MF, Gilmour HM, Shepherd NA, et al. Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. J Clin Pathol. 1997;50(2):93–105.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Wright CL, Riddell RH. Histology of the stomach and duodenum in Crohn’s disease. Am J Surg Pathol. 1998;22(4):383–90.

    Article  CAS  PubMed  Google Scholar 

  13. Cuvelier C, Demetter P, Mielants H, Veys EM, De Vos M. Interpretation of ileal biopsies: morphological features in normal and diseased mucosa. Histopathology. 2001;38(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  14. Shepherd NA, Jass JR. Neuromuscular and vascular hamartoma of the small intestine: is it Crohn’s disease? Gut. 1987;28(12):1663–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Histopathology, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Level 3, Sandringham Building, Infirmary Square, Leicester, LE1 5WW, UK

    Cathy J. Richards B Med Sci(Hons), BM BS, FRCPath

Authors
  1. Cathy J. Richards B Med Sci(Hons), BM BS, FRCPath
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cathy J. Richards B Med Sci(Hons), BM BS, FRCPath .

Editor information

Editors and Affiliations

  1. University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

    Arumugam Rajesh

  2. Department of Radiology, Warwick Hospital, Warwick, United Kingdom

    Rakesh Sinha

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Richards, C.J. (2015). Pathological Considerations in Crohn’s Disease. In: Rajesh, A., Sinha, R. (eds) Crohn's Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-01913-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-01913-0_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-01912-3

  • Online ISBN: 978-3-319-01913-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation