Abstract
Lymphedema is the result of impaired lymphatic function. Lymphedema is characterized by swelling of tissues, most commonly involving the lower extremities in 80 % of cases. It can also occur in the arms, face, trunk, and external genitalia. Leg edema is a common condition that is seen by all practicing clinicians. The differential diagnosis of lower extremity edema is extensive and includes systemic causes such as congestive heart failure, renal insufficiency, hepatic insufficiency, hypoalbuminemia, and medications and local causes such as deep vein thrombosis, venous insufficiency, lymphedema, lipedema, and cellulitis. A detailed understanding of the anatomy and physiology of the lymphatic system and the pathophysiology of lymphedema will contribute to the proper diagnosis and treatment of this complex and important clinical condition.
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References
Dellinger MT, Bernas MJ, Witte MH. Lymphatic biology and pathobiology. In: Dieter RS, Dieter Jr RA, Dieter RA, editors. Venous and lymphatic diseases. New York: McGraw Hill; 2011. p. 17–36.
Thanaporn PK, Rockson SG. Disease of the lymphatic vasculature. In: Dieter RS, Dieter Jr RA, Dieter RA, editors. Venous and lymphatic diseases. New York: McGraw Hill; 2011. p. 569–94.
Rockson SG. Diagnosis and management of lymphatic vascular disease. J Am Coll Cardiol. 2008;52(10):799–806.
Tiwari A, Cheng KS, Button M, Myint F, Hamilton G. Differential diagnosis, investigation, and current treatment of lower limb lymphedema. Arch Surg. 2003;138(2):152–61.
Ely JW, Osheroff JA, Chambliss ML, Ebell MH. Approach to leg edema of unclear etiology. J Am Board Fam Med. 2006;19(2):148–60.
Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature. 2005;438:946–53.
Rooke TW, Felty C. Lymphedema: pathophysiology, classification, and clinical evaluation. In: Gloviczki P, editor. Handbook of venous disorders. 3rd ed. London: Hodder Arnold; 2009. p. 629–34.
Kerchner K, Fleischer A, Yosipovitch G. Lower extremity lymphedema update: pathophysiology, diagnosis, and treatment guidelines. J Am Acad Dermatol. 2008;59(2):324–31.
International Society of Lymphology. The diagnosis and treatment of peripheral lymphedema. 2009 Concensus Document of the International Society of Lymphology. Lymphology. 2009;42(2):51–60.
Gamble GL, Cheville A, Strick D. Lymphedema: medical and physical therapy. In: Gloviczki P, editor. Handbook of venous disorders. 3rd ed. London: Hodder Arnold; 2009. p. 649–57.
Lee B, Andrade M, Bergan J, Boccardo F, Campisi C, Damstra R, et al. Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)-2009. Int Angiol. 2010;29(5):454–70.
Mortimer PS. ABC of arterial and venous disease swollen lower limb – 2: Lymphoedema. BMJ. 2000;320:1527–9.
Dean SM, Zirwas MJ, Horst AV. Elephantiasis nostras verrucosa: an institutional analysis of 21 cases. J Am Acad Dermatol. 2011;64(6):1104–10.
Cheville AL, McGarvey CL, Petrek JA, Russo SA, Taylor ME, Thiadens SR. Lymphedema management. Semin Radiat Oncol. 2003;13(3):290–301.
Mayrovitz HN. The standard of care for lymphedema: current concepts and physiological considerations. Lymphat Res Biol. 2009;7(2):101–8.
Badger C, Preston N, Seers K, Mortimer P. Physical therapies for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev. 2004;4, CD003141.
Partsch H, Mosti G. Thigh compression. Phlebology. 2008;23(6):252–8.
Partsch H, Flour M, Smith PC, International Compression Club. Indications for compression therapy in venous and lymphatic disease consensus based on experimental data and scientific evidence. Under the auspices of the IUP. Int Angiol. 2008;27(3):193–219.
Pappas CJ, O’Donnell Jr TF. Long-term results of compression treatment for lymphedema. J Vasc Surg. 1992;16(4):555–62.
Damstra RJ, Brouwer ER, Partsch H. Controlled, comparative study of relation between volume changes and interface pressure under short-stretch bandages in leg lymphedema patients. Dermatol Surg. 2008;34(6):773–8.
Mortimer PS. Therapy approaches for lymphedema. Angiology. 1997;48(1):87–91.
Keeley VL. Lymphoedema and cellulitis: chicken or egg? Br J Dermatol. 2008;158(6):1175–6.
Badger C, Preston N, Seers K, Mortimer P. Benzo-pyrones for reducing and controlling lymphoedema of the limbs. Cochrane Database Syst Rev. 2004;2, CD003140.
Casley-Smith JR. Benzo-pyrones in the treatment of lymphoedema. Int Angiol. 1999;18(1):31–41.
Loprinzi CL, Kugler JW, Sloan JA, Rooke TW, Quella SK, Novotny P, et al. Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. N Engl J Med. 1999;340(5):346–50.
Gloviczki P. Principles of surgical treatment of chronic lymphedema. In: Gloviczki P, editor. Handbook of venous disorders. 3rd ed. London: Hodder Arnold; 2009. p. 658–64.
Miller TA, Wyatt LE, Rudkin GH. Staged skin and subcutaneous excision for lymphedema: a favorable report of long-term results. Plast Reconstr Surg. 1998;102(5):1486–98.
Brorson H. From lymph to fat: complete reduction of lymphoedema. Phlebology. 2010;25 Suppl 1:52–63.
Brorson H, Ohlin K, Olsson G, Svensson B, Svensson H. Controlled compression and liposuction treatment for lower extremity lymphedema. Lymphology. 2008;41(2):52–63.
Campisi C, Bellini C, Campisi C, Accogli S, Bonioli E, Boccardo F. Microsurgery for lymphedema: clinical research and long-term results. Microsurgery. 2010;30(4):256–60.
Campisi C, Eretta C, Pertile D, Da Rin E, Campisi C, Macciò A, et al. Microsurgery for treatment of peripheral lymphedema: long-term outcome and future perspectives. Microsurgery. 2007;27(4):333–8.
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Laredo, J., Lee, B.B. (2014). Lymphedema. In: Mowatt-Larssen, E., Desai, S., Dua, A., Shortell, C. (eds) Phlebology, Vein Surgery and Ultrasonography. Springer, Cham. https://doi.org/10.1007/978-3-319-01812-6_23
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DOI: https://doi.org/10.1007/978-3-319-01812-6_23
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