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Lower Deep Vein Disease

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Phlebology, Vein Surgery and Ultrasonography

Abstract

Deep venous insufficiency may manifest as limb edema, chronic leg pain, stasis dermatitis, or ulceration, and the symptoms may be chronically disabling. Initial therapy is directed at ulcer healing and control of symptoms with wound care and compression. Once conservative measures have been instituted, the next step may be evaluation for any surgically correctable contributors to the symptomatology. Although valvular dysfunction and consequent venous reflux are a major cause of the venous hypertension that underlies the clinical manifestations of chronic venous insufficiency (CVI), recent studies suggest that iliac venous outflow obstruction plays a more important role in the pathogenesis of CVI than previously estimated. Any combination of superficial, perforator, and/or deep venous reflux can result in various stages of CVI, but when multiple segments of venous system are affected, the manifestations of CVI increase in severity. The combination of reflux and obstruction produces the highest levels of venous hypertension and the most severe clinical symptoms. This chapter discusses iliocaval vein obstructions and pelvic venous congestion.

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References

  1. Neglen P, Thrasher TL, Raju S. Venous outflow obstruction: an underestimated contributor to chronic venous disease. J Vasc Surg. 2003;38:879–85.

    Article  PubMed  Google Scholar 

  2. May R, Thurner J. The cause of the predominantly sinistral occurrence of thrombosis of the pelvic veins. Angiology. 1957;8:419–27.

    Article  PubMed  CAS  Google Scholar 

  3. Eklof B, Rutherford RB, Bergan JJ, et al. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg. 2004;40:1248–52.

    Article  PubMed  Google Scholar 

  4. Johnson BF, Manzo RA, Bergelin RO, Strandness DE. Relationship between changes in the deep venous system and the development of the postthrombotic syndrome after an acute episode of lower limb deep vein thrombosis: a one- to six- year follow-up. J Vasc Surg. 1995;21:307–13.

    Article  PubMed  CAS  Google Scholar 

  5. Akesson H, Brudin L, Dahlstrom JA, Eklof B, Ohlin P, Plate G. Venous function assessed during a 5-year period after acute iliofemoral venous thrombosis treated with anticoagulation. Eur J Vasc Surg. 1990;4:43–8.

    Article  PubMed  CAS  Google Scholar 

  6. Meissner MH, et al. Secondary chronic venous disorders. J Vasc Surg. 2007;46(Suppl 6):S68–83.

    Article  Google Scholar 

  7. Lin EP, Bhatt S, Rubens D, Dogra VS. The importance of monophasic Doppler waveforms in the common femoral vein: a retrospective study. J Ultrasound Med. 2007;26:885–91.

    PubMed  Google Scholar 

  8. Labropoulos N, Borge M, Pierce K, Pappas PJ. Criteria for defining significant central vein stenosis with duplex ultrasound. J Vasc Surg. 2007;46(1):101–7.

    Article  PubMed  Google Scholar 

  9. Neglen P, Thrasher TL, Raju S. Chronic venous insufficiency and varicose veins. N Engl J Med. 2006;360:22.

    Google Scholar 

  10. Kibbe MR, Ujiki M, Goodwin AL, Eskandari M, Yao J, Matsumura J. Iliac vein compression in an asymptomatic patient population. J Vasc Surg. 2004;39:937–43.

    Article  PubMed  Google Scholar 

  11. Hartung O, Benmiloud F, Barthelemy P, Dubuc M, Boufi M, Alimi YS. Late results of surgical venous thrombectomy with iliocaval stenting. J Vasc Surg. 2008;47:381–7.

    Article  PubMed  Google Scholar 

  12. Neglén P, Raju S. Intravascular ultrasound scan evaluation of the obstructed vein. J Vasc Surg. 2002;35:694–700.

    Article  PubMed  Google Scholar 

  13. Neglén P, Hollis KC, Olivier J, Raju S. Stenting of the venous outflow in chronic venous disease: long-term stent-related outcome, clinical, and hemodynamic result. J Vasc Surg. 2007;46:979–90.

    Article  PubMed  Google Scholar 

  14. Raju S. Endovenous treatment of patients with iliac-caval venous obstruction. J Cardiovasc Surg (Torino). 2008;49:27–33.

    CAS  Google Scholar 

  15. Hartung O, Otero A, Boufi M, Decaridi G, Barthelemy P, Juhan C, et al. Mid-term results of endovascular treatment for symptomatic chronic nonmalignant iliocaval venous occlusive disease. J Vasc Surg. 2005;42:1138–44; discussion 44.

    Article  PubMed  Google Scholar 

  16. Neglén P, Oglesbee M, Olivier J, Raju SJ. Stenting of chronically obstructed inferior vena cava filters. Vasc Surg. 2011;54(1):153–61.

    Article  Google Scholar 

  17. Palma EC, Esperon R. Vein transplants and grafts in the surgical treatment of the postphlebitic syndrome. J Cardiovasc Surg. 1960;1:94–107.

    CAS  Google Scholar 

  18. Jost CJ, Gloviczki P, Cherry Jr KJ, McKusick MA, Harmsen WS, Jenkins GD, et al. Surgical reconstruction of iliofemoral veins and the inferior vena cava for nonmalignant occlusive disease. J Vasc Surg. 2001;33:320–7; discussion 7-8.

    Article  PubMed  CAS  Google Scholar 

  19. Raju S, Berry MA, Neglen P. Transcommisural valvuloplasty: technique and results. J Vasc Surg. 2000;32(5):969–76.

    Article  PubMed  CAS  Google Scholar 

  20. Gloviczki P, Comerota AJ, Dalsing MC, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011;53(5 Suppl):2S–48.

    Article  PubMed  Google Scholar 

  21. Kim HS, Malhotra AD, Rowe PC, Lee JM, Venbrux AC. Embolotherapy for pelvic congestion syndrome: long-term results. J Vasc Interv Radiol. 2006;17(2 Pt 1):289–97.

    Article  PubMed  Google Scholar 

  22. El-Sadr A, Mina E. Anatomical and surgical aspects in the operative management of varicocele. Urol Cutaneous Rev. 1950;54:257–62.

    PubMed  CAS  Google Scholar 

  23. Rudloff U, Holmes RJ, Prem JT, Faust GR, Moldwin R, Seigel D. Mesoaortic compression of the left renal vein (nutcracker syndrome): case reports and review of the literature. Ann Vasc Surg. 2006;20:120–9.

    Article  PubMed  Google Scholar 

  24. Zerhouni EA, Siegelman SS, Walsh PC, White RI. Elevated pressure in the left renal vein in patients with varicocele: preliminary observations. J Urol. 1980;123:512–3.

    PubMed  CAS  Google Scholar 

  25. Beinart C, Sniderman KW, Tamura S, Vaughan ED, Sos TA. Left renal vein to inferior vena cava pressure relationship in humans. J Urol. 1982;127:1070–1.

    PubMed  CAS  Google Scholar 

  26. Hohenfellner M, Steinbach F, Schultz-Lampel W, et al. The nutcracker syndrome: new aspects of pathophysiology, diagnosis and treatment. J Urol. 1991;146:685–8.

    PubMed  CAS  Google Scholar 

  27. Reed NR, Kalra M, Bower TC, Vrtiska TJ, Ricotta 2nd JJ, Gloviczki P. Left renal vein transposition for nutcracker syndrome. J Vasc Surg. 2009;49:386–93.

    Article  PubMed  Google Scholar 

  28. Chen S, Zhang H, Shi H, et al. Endovascular stenting for treatment of Nutcracker syndrome: report of 61 cases with long-term followup. J Urol. 2011;186(2):570–5.

    Article  PubMed  Google Scholar 

  29. Raju S, Neglen P. Popliteal vein entrapment: a benign venographic feature or a pathologic entity? J Vasc Surg. 2000;31(4):631–41.

    Article  PubMed  CAS  Google Scholar 

  30. Lalka S. Management of chronic obstructive venous disease of the lower extremity. In: Rutherford RB, Johnson KW, et al., editors. Vascular surgery. Philadelphia: WB Saunders Company; 1995. p. 1869.

    Google Scholar 

  31. Raju S. Operative management of chronic venous insufficiency. In: Rutherford RB, Johnson KW, et al., editors. Vascular surgery. Philadelphia: WB Saunders Company; 1995. p. 1858.

    Google Scholar 

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Correspondence to Jovan N. Markovic MD .

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Markovic, J.N., Cox, M. (2014). Lower Deep Vein Disease. In: Mowatt-Larssen, E., Desai, S., Dua, A., Shortell, C. (eds) Phlebology, Vein Surgery and Ultrasonography. Springer, Cham. https://doi.org/10.1007/978-3-319-01812-6_16

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  • DOI: https://doi.org/10.1007/978-3-319-01812-6_16

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