Abstract
Determination of the CSF/SGlu ratio and/or CSF lactate concentration is part of the routine CSF work-up enabling the verification of an anaerobic glucose metabolism in the CNS. Since lactate is an end product of the anaerobic glucose metabolism and since there is an inverse relationship between CSF lactate and CSF/SGlu ratio, both parameters can be used for the same diagnostic purposes. A decrease of CSF/SGlu ratio and increase of CSF lactate, respectively, is found in various neurological diseases such as bacterial and fungal meningitis or leptomeningeal metastases. In glucose transporter-1 (GLUT1) deficiency syndromes, only the CSF/SGlu ratio is pathologic. A CSF/SGlu ratio ≤0.4 (with variations depending on blood glucose concentration) and CSF lactate >3.5 mmol/L are widely accepted as pathologic.
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Tumani, H., Hegen, H. (2015). Glucose and Lactate. In: Deisenhammer, F., Sellebjerg, F., Teunissen, C., Tumani, H. (eds) Cerebrospinal Fluid in Clinical Neurology. Springer, Cham. https://doi.org/10.1007/978-3-319-01225-4_7
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DOI: https://doi.org/10.1007/978-3-319-01225-4_7
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