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Lipid Metabolism in Metabolic Syndrome

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A Systems Biology Approach to Study Metabolic Syndrome

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Abstract

Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion and/or catabolism. To develop novel strategies for the prevention and treatment of dyslipidaemia, it is essential to better understand the lipid disorders in humans. Here we discuss recent advances in the field as well as show how the use of tracers labeled with stable isotopes combined with mathematical modelling provides a powerful tool for probing lipid and lipoprotein kinetics in vivo; thus furthering our understanding of the pathogenesis of lipid disorders.

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Authors and Affiliations

  1. Department of Molecular and Clinical Medicine, University of Gothenburg, Wallenberg Laboratory, 413 45, Gothenburg, Sweden

    Jan Borén & Martin Adiels

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  1. Jan Borén
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  2. Martin Adiels
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Correspondence to Jan Borén .

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Editors and Affiliations

  1. VTT Technical Research Centre of Finland, Espoo, Finland

    Matej Orešič

  2. Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

    Antonio Vidal-Puig

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Borén, J., Adiels, M. (2014). Lipid Metabolism in Metabolic Syndrome. In: Orešič, M., Vidal-Puig, A. (eds) A Systems Biology Approach to Study Metabolic Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-01008-3_8

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